Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels.
age-related macular degeneration
choroidal vascular dysfunction
dysregulated lipid metabolism
genetic factor
oxidative stress
pathogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jan 2021
28 Jan 2021
Historique:
received:
31
12
2020
revised:
25
01
2021
accepted:
25
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
4
9
2021
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.
Identifiants
pubmed: 33525498
pii: ijms22031296
doi: 10.3390/ijms22031296
pmc: PMC7866075
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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