Plasma Extracellular Vesicle Characteristics Correlate with Tumor Differentiation and Predict Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgery with Curative Intent.
extracellular vesicles
liquid biopsy
nanoparticle-tracking analysis
overall survival
pancreatic cancer
plasma biomarkers
tumor differentiation
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
28 Jan 2021
28 Jan 2021
Historique:
received:
30
11
2020
revised:
15
01
2021
accepted:
26
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
3
2
2021
Statut:
epublish
Résumé
Better preoperative characterization of patients with pancreatic ductal adenocarcinoma (PDAC) would aid in treatment optimization. Extracellular vesicles (EV) are promising, largely unexplored biomarkers in PDAC. This study aimed to evaluate if plasma EV characteristics are associated with PDAC clinical characteristics and overall survival (OS). The prospective cohort included 34 PDAC patients undergoing surgery with curative intent. Patient data and plasma samples were collected preoperatively, intraoperatively and one month postoperatively. Small plasma EV (sEV) concentration and size were determined by nanoparticle-tracking analysis. A Mann-Whitney test, Spearman's rho and Cox regression were used in statistical analysis. Preoperatively, patients with poorly differentiated tumors had significantly larger plasma sEVs when compared to patients with well/moderately differentiated tumors (mean diameter 176.9 vs. 149.2 nm,
Identifiants
pubmed: 33525618
pii: jpm11020077
doi: 10.3390/jpm11020077
pmc: PMC7910876
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P1-170
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J3-9255
Organisme : University Medical Centre Ljubljana
ID : No. 20150180
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