Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies.
Adipose-derived stem cells
diabetic foot ulcer
fat grafting
mesenchymal stem cells
platelet-Rich Plasma
wound healing
Journal
Adipocyte
ISSN: 2162-397X
Titre abrégé: Adipocyte
Pays: United States
ID NLM: 101567863
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
6
10
2021
Statut:
ppublish
Résumé
Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histology from animal studies on fat grafting, ADSC and PRP in wound healing. A literature review of major electronic databases was undertaken, and narrative synthesis performed. Data from 30 animal studies were included. ADSC increase angiogenesis over 14 days and often clinically accelerated wound healing. ADSC had a greater effect in animals with impaired wound healing (e.g. diabetes). Activated PRP increased viability of fat grafts. Despite the high number of studies, the quality is variable which weakens the evidence. It does suggest there is a benefit of ADSC, particularly in impaired wound healing. High-quality evidence in humans is required, to establish its clinical usefulness.
Identifiants
pubmed: 33525977
doi: 10.1080/21623945.2021.1876374
pmc: PMC7872055
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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