Intraductal Carcinomas of the Salivary Gland.

Carcinoma in Situ / classification Carcinoma, Intraductal, Noninfiltrating / classification Cell Proliferation Class I Phosphatidylinositol 3-Kinases / genetics DNA-Binding Proteins / genetics Diagnosis, Differential Gene Rearrangement Humans Immunohistochemistry Mutation Nuclear Proteins / genetics Prognosis Proto-Oncogene Proteins c-ret / genetics Proto-Oncogene Proteins p21(ras) / genetics Salivary Gland Neoplasms / classification
Intercalated duct type Intraductal carcinoma NCOA4-RET TRIM27-RET

Journal

Surgical pathology clinics
ISSN: 1875-9157
Titre abrégé: Surg Pathol Clin
Pays: United States
ID NLM: 101491209

Informations de publication

Date de publication:
Mar 2021
Historique:
entrez: 2 2 2021
pubmed: 3 2 2021
medline: 15 10 2021
Statut: ppublish

Résumé

Intraductal carcinoma of the salivary gland is a rare tumor characterized by intracystic proliferations of papillary, cribriform, and solid architecture of small uniform epithelial cells, reminiscent of ductal carcinoma in situ of the breast. Recent literature has identified 4 distinctive subtypes: the intercalated duct type, apocrine type, mixed/hybrid type, and oncocytic type, all with corresponding immunohistochemical and molecular findings. Although these tumors are typically in situ, as evidenced by a retained myoepithelial layer, they can demonstrate minimal invasion or, rarely, widespread invasive growth. Their overall prognosis is favorable, with few reported cases of recurrences and nodal metastases but no evidence of distant metastases.

Identifiants

DOI: 10.1016/j.path.2020.09.003 PMID: 33526215
pubmed: 33526215
pii: S1875-9181(20)30065-9
doi: 10.1016/j.path.2020.09.003
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
Nuclear Proteins 0
TRIM27 protein, human 0
Class I Phosphatidylinositol 3-Kinases EC 2.7.1.137
PIK3CA protein, human EC 2.7.1.137
Proto-Oncogene Proteins c-ret EC 2.7.10.1
RET protein, human EC 2.7.10.1
HRAS protein, human EC 3.6.5.2
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-15

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Emilija Todorovic (E)

Department of Laboratory Medicine and Pathobiology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Ilan Weinreb (I)

Department of Laboratory Medicine and Pathobiology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address: ILAN.WEINREB@UHN.CA.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Épithélioma in situ › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs canalaires, lobulaires et médullaires › Carcinome intracanalaire non infiltrant › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol-4-phosphate 3-kinase › Phosphatidylinositol 3-kinases de classe I › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Diagnostic › Diagnostic différentiel › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Phénomènes génétiques › Réarrangement des gènes › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Diagnostic › Pronostic › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-ret › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Intraductal Carcinomas of the Salivary Gland.
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies de la glande salivaire › Tumeurs des glandes salivaires › Intraductal Carcinomas of the Salivary Gland.