Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
08
10
2020
accepted:
27
12
2020
pubmed:
3
2
2021
medline:
18
9
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Higher resting heart rate (rHR) and lower heart rate variability (HRV) are associated with increased risk of cardiovascular disease (CVD) and all-cause mortality in people with and without diabetes. It is unknown whether temporal changes in rHR and HRV may contribute to this risk. We investigated associations between 5-year changes in rHR and HRV and risk of future CVD and death, taking into account participants' baseline glycemic state. In this prospective, population-based cohort study we investigated 4,611 CVD-free civil servants (mean [SD] age, 60 [5.9] years; 70% men). We measured rHR and/or six indices of HRV. Associations of 5-year change in 5-min rHR and HRV with fatal and nonfatal CVD and all-cause mortality or the composite of the two were assessed, with adjustments made for relevant confounders. Effect modification by glycemic state was tested. At baseline, 63% of participants were normoglycemic, 29% had prediabetes, and 8% had diabetes. During a median (interquartile range) follow-up of 11.9 (11.4; 12.3) years, 298 participants (6.5%) experienced a CVD event and 279 (6.1%) died of non-CVD-related causes. We found no association between 5-year changes in rHR and HRV and future events. Only baseline rHR was associated with all-cause mortality. A 10 bpm-higher baseline HR level was associated with an 11.4% higher rate of all-cause mortality (95% CI 1.0-22.9%; Changes in rHR and HRV and possibly also baseline values of these measures are not associated with future CVD or death in people with or without dysglycemia.
Identifiants
pubmed: 33526428
pii: dc20-2490
doi: 10.2337/dc20-2490
pmc: PMC7985416
doi:
Banques de données
figshare
['10.2337/figshare.13526351']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1012-1019Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL036310
Pays : United States
Organisme : British Heart Foundation
ID : RG/16/11/32334
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG013196
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056477
Pays : United States
Organisme : British Heart Foundation
ID : RG/13/2/30098
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : K013351
Pays : United Kingdom
Organisme : British Heart Foundation
ID : NH/16/2/32499
Pays : United Kingdom
Informations de copyright
© 2021 by the American Diabetes Association.
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