Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty.
cefazolin
hip joint capsule
population pharmacokinetic
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
18 03 2021
18 03 2021
Historique:
received:
07
10
2020
accepted:
24
01
2021
pubmed:
3
2
2021
medline:
22
6
2021
entrez:
2
2
2021
Statut:
epublish
Résumé
The objectives of this study were to evaluate the population pharmacokinetics of prophylactic cefazolin (CFZ) from its serum and hip joint capsule concentrations in patients undergoing total hip arthroplasty and to establish the pharmacodynamic target concentration exceeding the MIC for designing an effective dosing regimen for serum and the hip joint capsule. We analyzed 249 serum samples and 125 hip joint capsule samples from 125 individuals using a nonlinear mixed-effects model. The pharmacodynamic index target value obtained from our results indicates the probability of maintaining CFZ trough and hip joint capsule concentrations exceeding the MIC of 1 mg/liter to account for methicillin-susceptible
Identifiants
pubmed: 33526489
pii: AAC.02114-20
doi: 10.1128/AAC.02114-20
pmc: PMC8097485
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cefazolin
IHS69L0Y4T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 American Society for Microbiology.
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