Area-specific thalamocortical synchronization underlies the transition from motor planning to execution.
cerebellum
motor cortex
motor thalamus
movement initiation
nonhuman primates
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 02 2021
09 02 2021
Historique:
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
24
6
2021
Statut:
ppublish
Résumé
We studied correlated firing between motor thalamic and cortical cells in monkeys performing a delayed-response reaching task. Simultaneous recording of thalamocortical activity revealed that around movement onset, thalamic cells were positively correlated with cell activity in the primary motor cortex but negatively correlated with the activity of the premotor cortex. The differences in the correlation contrasted with the average neural responses, which were similar in all three areas. Neuronal correlations reveal functional cooperation and opposition between the motor thalamus and distinct motor cortical areas with specific roles in planning vs. performing movements. Thus, by enhancing and suppressing motor and premotor firing, the motor thalamus can facilitate the transition from a motor plan to execution.
Identifiants
pubmed: 33526664
pii: 2012658118
doi: 10.1073/pnas.2012658118
pmc: PMC8017695
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Neurophysiol. 2005 Jul;94(1):550-66
pubmed: 15703228
Neuron. 2019 Aug 7;103(3):506-519.e4
pubmed: 31201123
J Neurosci Methods. 2015 Oct 30;254:10-7
pubmed: 26192326
Nat Neurosci. 2007 Apr;10(4):462-8
pubmed: 17334362
Cereb Cortex. 2012 Aug;22(8):1904-14
pubmed: 21965441
Trends Neurosci. 2016 Oct;39(10):680-693
pubmed: 27589879
Elife. 2015 Dec 02;4:e10774
pubmed: 26633811
Cell Rep. 2018 May 1;23(5):1275-1285
pubmed: 29719244
Neurosci Res. 2000 Jan;36(1):73-9
pubmed: 10678534
Nature. 2020 Jan;577(7790):386-391
pubmed: 31875851
Biol Cybern. 2018 Apr;112(1-2):141-152
pubmed: 29094187
Front Syst Neurosci. 2018 Oct 18;12:41
pubmed: 30405364
J Neurophysiol. 1976 Sep;39(5):1032-44
pubmed: 824408
Nat Neurosci. 2014 Mar;17(3):440-8
pubmed: 24487233
J Neurophysiol. 1989 May;61(5):900-17
pubmed: 2723733
Brain Res Brain Res Rev. 2000 Mar;31(2-3):236-50
pubmed: 10719151
J Neurosci. 2016 Mar 23;36(12):3519-30
pubmed: 27013680
J Comp Neurol. 1989 Feb 15;280(3):468-88
pubmed: 2537345
J Neurosci. 1982 Sep;2(9):1329-45
pubmed: 7119878
J Neurophysiol. 2015 May 1;113(9):3090-7
pubmed: 25717161
Cell Rep. 2019 May 28;27(9):2608-2619.e4
pubmed: 31141686
Neuron. 2005 Oct 20;48(2):315-27
pubmed: 16242411
J Comp Neurol. 1974 Jan 1;153(1):77-106
pubmed: 4817346
Brain Res. 1973 May 30;55(1):1-24
pubmed: 4713188
Nature. 2018 Nov;563(7729):113-116
pubmed: 30333626