The evolving definition of salivary gland stem cells.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
16
07
2020
accepted:
03
12
2020
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
3
2
2021
Statut:
epublish
Résumé
Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenerating damaged salivary glands have been proposed as means to provide long-term restoration of tissue function in the affected patients. In studies to elucidate salivary gland regenerative mechanisms, more and more evidence suggests that salivary gland stem/progenitor cell behavior, like many other adult tissues, does not follow that of the hard-wired professional stem cells of the hematopoietic system. In this review, we provide evidence showing that several cell types within the salivary gland epithelium can serve as stem/progenitor-like cells. While these cell populations seem to function mostly as lineage-restricted progenitors during homeostasis, we indicate that upon damage specific plasticity mechanisms might be activated to take part in regeneration of the tissue. In light of these insights, we provide an overview of how recent developments in the adult stem cell research field are changing our thinking of the definition of salivary gland stem cells and their potential plasticity upon damage. These new perspectives may have important implications on the development of new therapeutic approaches to rescue radiation-induced hyposalivation.
Identifiants
pubmed: 33526786
doi: 10.1038/s41536-020-00115-x
pii: 10.1038/s41536-020-00115-x
pmc: PMC7851389
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4Subventions
Organisme : KWF Kankerbestrijding (Dutch Cancer Society)
ID : RUG 2013-5792
Références
Lab Invest. 2006 Oct;86(10):1052-63
pubmed: 16909128
Stem Cells. 2013 Apr;31(4):613-9
pubmed: 23335219
Stem Cells. 2016 Mar;34(3):640-52
pubmed: 26887347
PLoS One. 2014 Sep 19;9(9):e107893
pubmed: 25238060
Cell Stem Cell. 2010 Aug 6;7(2):214-24
pubmed: 20682447
Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1055-69
pubmed: 15990009
Trends Genet. 2020 Aug;36(8):587-597
pubmed: 32487496
Stem Cells. 2019 Sep;37(9):1144-1150
pubmed: 31175700
Science. 2012 Aug 31;337(6098):1091-3
pubmed: 22821983
Leukemia. 2012 Jun;26(6):1166-73
pubmed: 22182853
Cancer Res. 2020 Dec 15;80(24):5531-5542
pubmed: 32998998
Dev Cell. 2015 Apr 20;33(2):231-7
pubmed: 25843887
Cell Rep. 2018 Aug 7;24(6):1464-1470.e3
pubmed: 30089258
Science. 2010 Sep 24;329(5999):1645-7
pubmed: 20929848
Stem Cells Dev. 2015 Mar 1;24(5):565-74
pubmed: 25244667
Stem Cell Reports. 2014 Dec 9;3(6):957-64
pubmed: 25448065
Annu Rev Biochem. 2018 Jun 20;87:1015-1027
pubmed: 29494240
Crit Rev Oral Biol Med. 2003;14(3):199-212
pubmed: 12799323
Kaibogaku Zasshi. 1995 Aug;70(4):330-7
pubmed: 8540281
Cell Tissue Kinet. 1989 Sep;22(5):343-8
pubmed: 2611851
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2520-4
pubmed: 6585813
Am J Surg Pathol. 1989 Oct;13(10):879-99
pubmed: 2675654
Acta Histochem Cytochem. 2012 Oct 31;45(5):241-50
pubmed: 23209333
Cell Tissue Kinet. 1974 Jan;7(1):77-88
pubmed: 4129708
J Investig Dermatol Symp Proc. 2004 Sep;9(3):196-201
pubmed: 15369213
Sci Rep. 2018 Sep 21;8(1):14193
pubmed: 30242278
Nature. 2019 May;569(7754):121-125
pubmed: 31019301
Cell. 1978 Nov;15(3):899-906
pubmed: 728994
Cell. 2008 Dec 12;135(6):1118-29
pubmed: 19062086
Cell. 2010 Oct 1;143(1):134-44
pubmed: 20887898
Nat Rev Genet. 2017 Nov;18(11):643-658
pubmed: 28804139
Elife. 2017 Jun 17;6:
pubmed: 28623666
Stem Cell Reports. 2016 Jan 12;6(1):150-62
pubmed: 26724906
BMC Cancer. 2014 Nov 21;14:856
pubmed: 25413127
Cell. 2012 Jul 6;150(1):136-50
pubmed: 22770217
Anat Rec. 1993 Mar;235(3):475-85
pubmed: 8430917
Development. 2010 Jul;137(14):2289-96
pubmed: 20534672
Development. 2020 Oct 9;147(19):
pubmed: 32994165
Cell. 2008 Feb 22;132(4):631-44
pubmed: 18295580
Cell. 1990 Jun 29;61(7):1329-37
pubmed: 2364430
Mol Ther Methods Clin Dev. 2020 Jul 31;18:839-855
pubmed: 32953934
Front Oral Biol. 2010;14:90-106
pubmed: 20428013
Cell Tissue Res. 1985;242(3):551-6
pubmed: 2416451
Development. 2018 Nov 5;145(21):
pubmed: 30305288
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19403-7
pubmed: 23129637
Dev Cell. 2018 Feb 26;44(4):532
pubmed: 29486197
Nature. 2017 Jul 20;547(7663):350-354
pubmed: 28700576
Sci Transl Med. 2015 Sep 16;7(305):305ra147
pubmed: 26378247
Nature. 2012 Apr 15;484(7395):546-9
pubmed: 22504183
Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):449-53
pubmed: 20056347
EMBO J. 2015 May 5;34(9):1164-79
pubmed: 25812989
Development. 2010 Nov;137(22):3753-61
pubmed: 20978073
PLoS One. 2016 Jan 11;11(1):e0146711
pubmed: 26751783
Differentiation. 2007 Oct;75(8):702-12
pubmed: 17381540
Genesis. 2018 May;56(5):e23211
pubmed: 29663717
Cell Tissue Res. 2020 Jun;380(3):487-497
pubmed: 31900666
Radiother Oncol. 2002 Jun;63(3):321-8
pubmed: 12142096
Cell Rep. 2013 Oct 31;5(2):349-56
pubmed: 24209744
Mol Oncol. 2020 Jul;14(7):1538-1554
pubmed: 32521079
Development. 2011 Aug;138(15):3103-11
pubmed: 21750026
Cell Stem Cell. 2014 Feb 6;14(2):149-59
pubmed: 24332836
Cell Stem Cell. 2010 Feb 5;6(2):103-15
pubmed: 20144784
Stem Cells Transl Med. 2017 Jan;6(1):110-120
pubmed: 28170182
PLoS One. 2013 Sep 18;8(9):e74174
pubmed: 24058524
Trends Cell Biol. 2013 Aug;23(8):357-64
pubmed: 23597843
Sci Immunol. 2020 Apr 3;5(46):
pubmed: 32245888
Science. 2010 Nov 5;330(6005):822-5
pubmed: 20929733
Nature. 2013 Mar 7;495(7439):65-9
pubmed: 23446353
Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1187-94
pubmed: 15990024
PLoS One. 2015 Dec 30;10(12):e0145724
pubmed: 26717480
Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):983-91
pubmed: 20970030
Int J Radiat Oncol Biol Phys. 2001 Nov 15;51(4):938-46
pubmed: 11704314
NPJ Regen Med. 2018 Feb 23;3:6
pubmed: 29507774
Nature. 2006 Jan 5;439(7072):84-8
pubmed: 16397499
Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49(1):83-91
pubmed: 2862738
Genetics. 1964 Apr;49(4):561-76
pubmed: 17248204
Antioxid Redox Signal. 2014 Jul 10;21(2):338-55
pubmed: 24147585
Stem Cell Rev Rep. 2012 Jun;8(2):414-25
pubmed: 21744048
Anat Rec. 2001 Jun 1;263(2):202-14
pubmed: 11360236
J Hum Genet. 2018 Feb;63(2):165-178
pubmed: 29192237
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29335337
J Cell Sci Suppl. 1988;10:45-62
pubmed: 3077942
Nat Rev Mol Cell Biol. 2020 Jul;21(7):398-414
pubmed: 32251387
Gastroenterology. 2011 Aug;141(2):731-41, 741.e1-4
pubmed: 21703267
Development. 2013 Feb;140(4):751-64
pubmed: 23325761
Nat Cell Biol. 2016 Mar;18(3):238-45
pubmed: 26911907
Br J Cancer. 2001 Sep 28;85(7):1055-63
pubmed: 11592779