Acquisition and carriage of multidrug-resistant organisms in dogs and cats presented to small animal practices and clinics in Switzerland.
carbapenemase-producing enterobacterales
extended-spectrum β-lactamase
risk factors
transmission
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
revised:
28
12
2020
received:
12
09
2020
accepted:
15
01
2021
pubmed:
3
2
2021
medline:
29
6
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
The emergence and spread of multidrug-resistant organisms (MDRO) present a threat to human and animal health. To assess acquisition, prevalence of and risk factors for MDRO carriage in dogs and cats presented to veterinary clinics or practices in Switzerland. Privately owned dogs (n = 183) and cats (n = 88) presented to 4 veterinary hospitals and 1 practice. Prospective, longitudinal, observational study. Oronasal and rectal swabs were collected at presentation and 69% of animals were sampled again at discharge. Methicillin-resistant (MR) staphylococci and macrococci, cephalosporinase-, and carbapenemase-producing (CP) Enterobacterales were isolated. Genetic relatedness of isolates was assessed by repetitive sequence-based polymerase chain reaction and multilocus sequence typing. Risk factors for MDRO acquisition and carriage were analyzed based on questionnaire-derived and hospitalization data. Admission prevalence of MDRO carriage in pets was 15.5% (95% confidence interval [CI], 11.4-20.4). The discharge prevalence and acquisition rates were 32.1% (95% CI, 25.5-39.3) and 28.3% (95% CI, 22-35.4), respectively. Predominant hospital-acquired isolates were extended spectrum β-lactamase-producing Escherichia coli (ESBL-E coli; 17.3%) and β-lactamase-producing Klebsiella pneumoniae (13.7%). At 1 institution, a cluster of 24 highly genetically related CP (bla Veterinary hospitals play an important role in the selection and transmission of MDRO among veterinary patients.
Sections du résumé
BACKGROUND
BACKGROUND
The emergence and spread of multidrug-resistant organisms (MDRO) present a threat to human and animal health.
OBJECTIVES
OBJECTIVE
To assess acquisition, prevalence of and risk factors for MDRO carriage in dogs and cats presented to veterinary clinics or practices in Switzerland.
ANIMALS
METHODS
Privately owned dogs (n = 183) and cats (n = 88) presented to 4 veterinary hospitals and 1 practice.
METHODS
METHODS
Prospective, longitudinal, observational study. Oronasal and rectal swabs were collected at presentation and 69% of animals were sampled again at discharge. Methicillin-resistant (MR) staphylococci and macrococci, cephalosporinase-, and carbapenemase-producing (CP) Enterobacterales were isolated. Genetic relatedness of isolates was assessed by repetitive sequence-based polymerase chain reaction and multilocus sequence typing. Risk factors for MDRO acquisition and carriage were analyzed based on questionnaire-derived and hospitalization data.
RESULTS
RESULTS
Admission prevalence of MDRO carriage in pets was 15.5% (95% confidence interval [CI], 11.4-20.4). The discharge prevalence and acquisition rates were 32.1% (95% CI, 25.5-39.3) and 28.3% (95% CI, 22-35.4), respectively. Predominant hospital-acquired isolates were extended spectrum β-lactamase-producing Escherichia coli (ESBL-E coli; 17.3%) and β-lactamase-producing Klebsiella pneumoniae (13.7%). At 1 institution, a cluster of 24 highly genetically related CP (bla
CONCLUSIONS
CONCLUSIONS
Veterinary hospitals play an important role in the selection and transmission of MDRO among veterinary patients.
Identifiants
pubmed: 33527554
doi: 10.1111/jvim.16038
pmc: PMC7995377
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Observational Study, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
970-979Subventions
Organisme : National Research Programme, Antimicrobial Resistance of Swiss National Science Foundation
ID : 177378
Organisme : Swiss Federal Food Safety and Veterinary Office (FSVO)
ID : 1.18.10
Informations de copyright
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.
Références
Front Microbiol. 2013 Mar 14;4:48
pubmed: 23504089
Vet Microbiol. 2014 May 14;170(1-2):10-8
pubmed: 24576841
J Clin Microbiol. 2002 Aug;40(8):2786-90
pubmed: 12149330
Vet Microbiol. 2017 Feb;199:23-30
pubmed: 28110781
Euro Surveill. 2018 Jul;23(27):
pubmed: 29991384
Vet Dermatol. 2013 Oct;24(5):538-e128
pubmed: 23869430
Int J Syst Evol Microbiol. 2017 Mar;67(3):621-626
pubmed: 27902286
BMC Vet Res. 2018 Oct 3;14(1):300
pubmed: 30285752
R Soc Open Sci. 2019 Oct 16;6(10):191170
pubmed: 31824726
Vet Microbiol. 2018 Jan;213:136-141
pubmed: 29291997
Am J Infect Control. 2012 Mar;40(2):128-33
pubmed: 21824684
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2972-80
pubmed: 26953207
J Infect Dis. 2017 Feb 15;215(suppl_1):S28-S36
pubmed: 28375512
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
J Clin Microbiol. 2012 Jul;50(7):2466-8
pubmed: 22535993
Zoonoses Public Health. 2018 Aug;65(5):519-527
pubmed: 29575700
Int J Med Microbiol. 2014 Oct;304(7):787-93
pubmed: 25130703
J Clin Microbiol. 2014 May;52(5):1798-9
pubmed: 24554751
J Clin Microbiol. 2017 Oct;55(10):3138-3141
pubmed: 28768732
Microb Drug Resist. 2017 Mar;23(2):194-205
pubmed: 27249658
BMC Vet Res. 2019 Mar 14;15(1):94
pubmed: 30871537
Antimicrob Agents Chemother. 2015 Aug;59(8):4577-83
pubmed: 25987634
J Antimicrob Chemother. 2019 Oct 1;74(10):2880-2890
pubmed: 31361004
Diagn Microbiol Infect Dis. 2016 Aug;85(4):471-6
pubmed: 27241371
Acta Vet Scand. 2019 Oct 31;61(1):51
pubmed: 31672159
Antimicrob Resist Infect Control. 2020 Jun 23;9(1):93
pubmed: 32576281
J Antimicrob Chemother. 2020 Feb 1;75(2):342-350
pubmed: 31711228
J Glob Antimicrob Resist. 2020 Sep;22:94-101
pubmed: 31887413
J Antimicrob Chemother. 2011 Oct;66(10):2248-54
pubmed: 21733964
J Clin Microbiol. 2013 Dec;51(12):4281-3
pubmed: 24108615
Euro Surveill. 2019 Sep;24(39):
pubmed: 31576806
J Antimicrob Chemother. 2012 Jul;67(7):1597-606
pubmed: 22499996
Clin Microbiol Infect. 2012 May;18(5):432-8
pubmed: 22507110
BMC Vet Res. 2014 Jan 14;10:17
pubmed: 24423104
BMC Vet Res. 2011 Jun 24;7:30
pubmed: 21702906
Nat Rev Microbiol. 2015 Jan;13(1):42-51
pubmed: 25435309
J Antimicrob Chemother. 2020 Mar 1;75(3):766-768
pubmed: 31819979
Antimicrob Agents Chemother. 2015 May;59(5):2949-55
pubmed: 25733505
Vet Microbiol. 2017 Feb;200:71-78
pubmed: 27291944
J Vet Sci. 2013;14(4):449-56
pubmed: 23820161
J Vet Intern Med. 2021 Mar;35(2):970-979
pubmed: 33527554
J Antimicrob Chemother. 2010 Jun;65(6):1145-54
pubmed: 20348087
Curr Opin Anaesthesiol. 2020 Apr;33(2):156-161
pubmed: 31904697
Am J Infect Control. 2020 Sep;48(9):1028-1031
pubmed: 31924388
Zoonoses Public Health. 2020 May;67(3):222-230
pubmed: 31867885
J Antimicrob Chemother. 2019 Sep 1;74(9):2531-2536
pubmed: 31243455
Int J Food Microbiol. 2019 Jan 16;289:162-167
pubmed: 30245289
Vet Microbiol. 2018 Jul;221:59-66
pubmed: 29981709
Int J Antimicrob Agents. 2016 Dec;48(6):759-760
pubmed: 27692239
PLoS One. 2017 Nov 2;12(11):e0187239
pubmed: 29095871
J Antimicrob Chemother. 2017 Apr 1;72(4):957-968
pubmed: 27999066
Can Vet J. 2009 Oct;50(10):1047-53
pubmed: 20046603
Sci Rep. 2017 Mar 08;7:43797
pubmed: 28272476
Vet Microbiol. 2018 Sep;223:79-85
pubmed: 30173756
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
Microb Drug Resist. 2014 Oct;20(5):485-94
pubmed: 24773305
J Vet Intern Med. 2019 Jul;33(4):1677-1685
pubmed: 31119803
Front Microbiol. 2016 Jul 11;7:1057
pubmed: 27462301
Vet Dermatol. 2017 Dec;28(6):559-e133
pubmed: 28748533
Food Microbiol. 2015 Oct;51:51-6
pubmed: 26187827
J Glob Antimicrob Resist. 2018 Mar;12:17-19
pubmed: 29175015
Front Microbiol. 2018 Dec 06;9:2872
pubmed: 30574124
Vet Rec Open. 2020 Mar 9;7(1):e000370
pubmed: 32201578
J Am Vet Med Assoc. 2013 Oct 1;243(7):990-1000
pubmed: 24050566
Antimicrob Agents Chemother. 2014 Oct;58(10):6320-3
pubmed: 25092703
Lett Appl Microbiol. 2014 Jul;59(1):1-8
pubmed: 24730724