Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project.
Age Factors
Aged
Alzheimer Disease
Brain
/ metabolism
Educational Status
Europe
Fluorodeoxyglucose F18
/ metabolism
Frontal Lobe
/ metabolism
Gyrus Cinguli
/ metabolism
Humans
Image Processing, Computer-Assisted
/ statistics & numerical data
Lewy Body Disease
/ metabolism
Positron-Emission Tomography
biomarkers
cognitive reserve
dementia with Lewy bodies
fluorodeoxyglucose positron emission tomography
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
29
12
2020
received:
03
12
2020
accepted:
31
12
2020
pubmed:
3
2
2021
medline:
20
11
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1277-1286Informations de copyright
© 2021 the Alzheimer's Association.
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