The Interface of Therapeutics and Genomics in Cardiovascular Medicine.
Mendelian randomisation
Pharmacogenomics
Risk scores
Therapeutics
Journal
Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
accepted:
19
01
2021
pubmed:
3
2
2021
medline:
16
12
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Pharmacogenomics has a burgeoning role in cardiovascular medicine, from warfarin dosing to antiplatelet choice, with recent developments in sequencing bringing the promise of personalised medicine ever closer to the bedside. Further scientific evidence, real-world clinical trials, and economic modelling are needed to fully realise this potential. Additionally, tools such as polygenic risk scores, and results from Mendelian randomisation analyses, are only in the early stages of clinical translation and merit further investigation. Genetically targeted rational drug design has a strong evidence base and, due to the nature of genetic data, academia, direct-to-consumer companies, healthcare systems, and industry may meet in an unprecedented manner. Data sharing navigation may prove problematic. The present manuscript addresses these issues and concludes a need for further guidance to be provided to prescribers by professional bodies to aid in the consideration of such complexities and guide translation of scientific knowledge to personalised clinical action, thereby striving to improve patient care. Additionally, technologic infrastructure equipped to handle such large complex data must be adapted to pharmacogenomics and made user friendly for prescribers and patients alike.
Identifiants
pubmed: 33528719
doi: 10.1007/s10557-021-07149-3
pii: 10.1007/s10557-021-07149-3
pmc: PMC7851637
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
663-676Subventions
Organisme : Medical Research Council
ID : G1000417
Pays : United Kingdom
Références
Biophys Rev. 2017 Jun;9(3):207-223
pubmed: 28510119
Lancet. 2015 Jun 6;385(9984):2280-7
pubmed: 25769357
Nat Rev Drug Discov. 2004 Aug;3(8):673-83
pubmed: 15286734
Clin Pharmacol Ther. 2014 Mar;95(3):281-93
pubmed: 24322971
EBioMedicine. 2020 Jul;57:102847
pubmed: 32574960
BMJ. 2011 Feb 15;342:d548
pubmed: 21325005
Circ Genom Precis Med. 2018 Sep;11(9):e002228
pubmed: 30354330
Ann Neurol. 2020 Jan;87(1):30-39
pubmed: 31714636
Clin Pharmacol Ther. 2018 Feb;103(2):281-286
pubmed: 28653333
BMC Med. 2019 Apr 8;17(1):76
pubmed: 30961588
PLoS Genet. 2019 Dec 12;15(12):e1008489
pubmed: 31830040
Clin Transl Sci. 2020 Mar;13(2):381-390
pubmed: 31808996
Pac Symp Biocomput. 2021;26:184-195
pubmed: 33691016
JACC Cardiovasc Interv. 2018 Jan 22;11(2):181-191
pubmed: 29102571
Sci Rep. 2018 Feb 21;8(1):3434
pubmed: 29467471
Clin Pharmacol Ther. 2017 Mar;101(3):341-358
pubmed: 28027596
PLoS One. 2016 Jan 11;11(1):e0146262
pubmed: 26752539
Circulation. 2020 Feb 25;141(8):616-623
pubmed: 31707849
J Comp Eff Res. 2018 Jun;7(6):603-614
pubmed: 29478331
BMJ. 2018 Jul 12;362:k601
pubmed: 30002074
J Community Genet. 2020 Jul;11(3):269-277
pubmed: 32468238
J Am Coll Cardiol. 2016 Jan 19;67(2):230-231
pubmed: 26791069
JAMA Intern Med. 2014 Dec;174(12):1938-44
pubmed: 25317785
PLoS One. 2020 Jul 21;15(7):e0236193
pubmed: 32692755
Clin Pharmacol Ther. 2013 Sep;94(3):317-23
pubmed: 23698643
Clin Pharmacol Ther. 2020 Aug;108(2):287-297
pubmed: 32128760
Lancet. 2005 Dec 3;366(9501):1906-8
pubmed: 16325682
N Engl J Med. 2013 Dec 12;369(24):2294-303
pubmed: 24251363
Genes (Basel). 2019 Apr 01;10(4):
pubmed: 30939847
Curr Pharm Des. 2015;21(6):806-22
pubmed: 25341854
Br J Clin Pharmacol. 2016 Sep;82(3):683-95
pubmed: 27197003
Circulation. 2019 Jul 23;140(4):270-279
pubmed: 31234639
Circ Genom Precis Med. 2020 Aug;13(4):e002922
pubmed: 32469608
Nat Med. 2020 Apr;26(4):549-557
pubmed: 32273609
Transl Psychiatry. 2019 Sep 5;9(1):219
pubmed: 31488809
Pharmacogenet Genomics. 2020 Aug;30(6):131-144
pubmed: 32317559
BMC Health Serv Res. 2020 Apr 3;20(1):279
pubmed: 32245380
N Engl J Med. 2019 Oct 24;381(17):1621-1631
pubmed: 31479209
Genet Med. 2014 Mar;16(3):251-7
pubmed: 24232413
Bull World Health Organ. 2008 Apr;86(4):317-9
pubmed: 18438522
Genet Med. 2020 Mar;22(3):475-486
pubmed: 31591509
Clin Pharmacol Ther. 2012 May;91(5):774-6
pubmed: 22513313
J Pers Med. 2018 Jun 28;8(3):
pubmed: 29958440
Pharmacogenomics. 2013 Nov;14(15):1833-47
pubmed: 24236483
J Card Fail. 2017 Jun;23(6):476-479
pubmed: 28315399
Trends Pharmacol Sci. 2015 Mar;36(3):153-63
pubmed: 25698605
Clin Pharmacol Ther. 2018 Oct;104(4):664-674
pubmed: 29280137
Nat Rev Drug Discov. 2019 Jan;18(1):41-58
pubmed: 30310233
Pharmacogenomics. 2020 Aug;21(12):821-825
pubmed: 32723135
Am Heart J. 2014 Jul;168(1):16-22.e1
pubmed: 24952855
N Engl J Med. 2013 Dec 12;369(24):2283-93
pubmed: 24251361
Genet Med. 2013 Apr;15(4):258-67
pubmed: 23306799
Lancet. 2015 Jan 24;385(9965):351-61
pubmed: 25262344
Pharmacoeconomics. 2010;28(1):61-74
pubmed: 20014877
Arch Virol. 2020 Aug;165(8):1729-1737
pubmed: 32514689
Curr Treat Options Cardiovasc Med. 2019 May 18;21(6):27
pubmed: 31104193
Lancet Public Health. 2019 Apr;4(4):e189-e199
pubmed: 30954144
PLoS One. 2017 Nov 6;12(11):e0187574
pubmed: 29107969
Circulation. 2019 Jul 2;140(1):31-41
pubmed: 30987448
Clin Pharmacol Ther. 2018 Mar;103(3):409-418
pubmed: 29171014
Clin Pharmacol Ther. 2017 Sep;102(3):397-404
pubmed: 28198005
Mayo Clin Proc. 2018 Jan;93(1):113-120
pubmed: 29304915
PLoS One. 2015 Dec 23;10(12):e0145284
pubmed: 26701604
Circulation. 2020 Jul 28;142(4):324-338
pubmed: 32429735
JACC Heart Fail. 2019 Jul;7(7):586-598
pubmed: 31042551
Genome Med. 2013 Jan 11;5(1):1
pubmed: 23311897
J Clin Oncol. 2012 May 1;30(13):1422-8
pubmed: 21900104
Int J Behav Med. 2017 Jun;24(3):321-419
pubmed: 28290077
Pharmacogenet Genomics. 2006 Dec;16(12):873-9
pubmed: 17108811
Nature. 2014 Jan 16;505(7483):286-7
pubmed: 24436984
Nat Rev Drug Discov. 2012 Mar 30;11(4):267-8
pubmed: 22460117
Circ Genom Precis Med. 2019 Jun;12(6):e002481
pubmed: 31184202
Pharmacol Rev. 2013 May 17;65(3):987-1009
pubmed: 23686351
Circulation. 2020 Feb 25;141(8):624-636
pubmed: 31707832
Mol Pharmacol. 2009 Jun;75(6):1337-46
pubmed: 19297519
J Intern Med. 2015 Nov;278(5):433-46
pubmed: 26477595
Circ Genom Precis Med. 2018 Aug;11(8):e001977
pubmed: 30354342
Front Cardiovasc Med. 2019 Jul 17;6:91
pubmed: 31380393
Am Heart J. 2020 Apr;222:157-165
pubmed: 32087417
J Am Coll Cardiol. 2018 Oct 16;72(16):1883-1893
pubmed: 30309464
Clin Pharmacol Ther. 2021 Jan;109(1):160-174
pubmed: 32535895
Am J Hum Genet. 2019 Sep 5;105(3):588-605
pubmed: 31447099
Circ Cardiovasc Interv. 2019 Apr;12(4):e007811
pubmed: 30998396
J Clin Med. 2019 Dec 20;9(1):
pubmed: 31861911
Circulation. 2017 Apr 4;135(14):1300-1310
pubmed: 28213480
Nat Genet. 2015 Sep;47(9):1079-84
pubmed: 26237429
Am J Hum Genet. 2019 Jan 3;104(1):13-20
pubmed: 30609404
Thromb Haemost. 2015 Apr;113(4):772-81
pubmed: 25503805
Clin Pharmacol Ther. 2012 Nov;92(5):584-98
pubmed: 23047648
Nat Med. 2020 Oct;26(10):1541-1548
pubmed: 32895570
JAMA. 2020 Aug 25;324(8):761-771
pubmed: 32840598
PLoS One. 2013 Nov 06;8(11):e78511
pubmed: 24223155
AAPS J. 2012 Dec;14(4):759-63
pubmed: 22826034
JAMA. 2020 Feb 18;323(7):636-645
pubmed: 32068818
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
JAMA. 2020 Feb 18;323(7):627-635
pubmed: 32068817
Lancet. 2012 Mar 31;379(9822):1214-24
pubmed: 22421340
J Muscle Res Cell Motil. 2019 Jun;40(2):159-167
pubmed: 31147888
Circ Cardiovasc Genet. 2016 Dec;9(6):531-540
pubmed: 27780846
Cardiovasc Res. 2021 Jan 1;117(1):284-291
pubmed: 32243492
Nat Genet. 2015 Aug;47(8):856-60
pubmed: 26121088
Clin Pharmacol Ther. 2018 Apr;103(4):599-618
pubmed: 28994452
Pediatr Blood Cancer. 2013 Aug;60(8):1375-81
pubmed: 23441093
Nat Biotechnol. 2012 Apr 10;30(4):317-20
pubmed: 22491277
Pharmacogenomics J. 2017 Oct;17(5):395-402
pubmed: 28607506
Circ Genom Precis Med. 2019 Jun;12(6):e002390
pubmed: 31059280
N Engl J Med. 2012 Feb 16;366(7):619-28
pubmed: 22335739
JAMA. 2017 Sep 26;318(12):1115-1124
pubmed: 28973620
Med Res Rev. 2021 Jan;41(1):5-28
pubmed: 32864815
Drug Saf. 2015 Oct;38(10):855-67
pubmed: 26108299
Int J Biol Sci. 2018 Jul 13;14(10):1232-1244
pubmed: 30123072
Appl Transl Genom. 2016 Feb 02;8:16-22
pubmed: 27047755
Int J Epidemiol. 2017 Dec 1;46(6):2078-2089
pubmed: 29040597
Hum Mol Genet. 2018 Aug 1;27(R2):R195-R208
pubmed: 29771313
Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105
pubmed: 27908689
Clin Pharmacol Ther. 2012 Jul;92(1):112-7
pubmed: 22617227