Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures

Amphotericin B Animals Antiprotozoal Agents / pharmacology Aziridines Disease Models, Animal Leishmania major Mice Mice, Inbred BALB C
CB1954 combination treatment cutaneous leishmaniasis tretazicar

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
12 02 2021
Historique:
pubmed: 3 2 2021
medline: 24 6 2021
entrez: 2 2 2021
Statut: ppublish

Résumé

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis affecting human populations, yet CL remains largely ignored in drug discovery programs. CL causes disfiguring skin lesions and often relapses after "clinical cure" using existing therapeutics. To expand the pool of anti-CL lead candidates, we implemented an integrated screening platform comprising three progressive

Identifiants

DOI: 10.1021/acsinfecdis.0c00886 PMID: 33529014
pubmed: 33529014
doi: 10.1021/acsinfecdis.0c00886
doi:

Substances chimiques

Antiprotozoal Agents 0
Aziridines 0
liposomal amphotericin B 0
tretazicar 7865D5D01M
Amphotericin B 7XU7A7DROE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

506-517

Auteurs

Diana Caridha (D)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Richard J Sciotti (RJ)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.
ORCID: 0000-0002-3069-3122

Jason Sousa (J)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Brian Vesely (B)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Tesfaye Teshome (T)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Gustave Bonkoungou (G)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Chau Vuong (C)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Susan Leed (S)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Mozna Khraiwesh (M)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Erica Penn (E)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Mara Kreishman-Deitrick (M)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Patricia Lee (P)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

Brandon Pybus (B)

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States.

John S Lazo (JS)

University of Virginia, Department of Pharmacology, 409 Lane Road, MR4, Charlottesville, Virginia 22908, United States.
ORCID: 0000-0002-0645-4025

Elizabeth R Sharlow (ER)

University of Virginia, Department of Pharmacology, 409 Lane Road, MR4, Charlottesville, Virginia 22908, United States.
ORCID: 0000-0002-7957-3594

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Lactones › Amphotéricine B › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Eucaryotes › Animaux › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azirines › Aziridines › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Leishmania major › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Combination of Subtherapeutic Doses of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Combination of Subtherapeutic Doses of...