Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
10
2020
accepted:
19
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Leukocyte telomere length (LTL) is one of the markers of biological aging as shortening occurs over time. Shorter LTL has been associated with adiposity and a higher risk of cardiovascular diseases. The objective was to assess LTL and LTL shortening during the first 2 years of life in healthy, term-born infants and to associate LTL shortening with potential stressors and body composition. In 145 healthy, term-born infants (85 boys), we measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique. Fat mass (FM) was assessed longitudinally by PEAPOD, DXA, and abdominal FM by ultrasound. LTL decreased by 8.5% from 3 months to 2 years (T/S ratio 4.10 vs 3.75, p<0.001). LTL shortening from 3 months to 2 years associated with FM%(R = 0.254), FM index(R = 0.243) and visceral FM(R = 0.287) at 2 years. LTL shortening tended to associate with gain in FM% from 3 to 6 months (R = 0.155, p = 0.11), in the critical window for adiposity programming. There was a trend to a shorter LTL in boys at 2 years(p = 0.056). LTL shortening from 3 months to 2 years was not different between sexes. We present longitudinal LTL values and show that LTL shortens considerably (8.5%) during the first 2 years of life. LTL shortening during first 2 years of life was associated with FM%, FMI and visceral FM at age 2 years, suggesting that adverse adiposity programming in early life could contribute to more LTL shortening.
Identifiants
pubmed: 33529269
doi: 10.1371/journal.pone.0246400
pii: PONE-D-20-33111
pmc: PMC7853438
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0246400Subventions
Organisme : Medical Research Council
ID : MR/M012816/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
The Sophia Pluto Study is an investigator-initiated study; AHK received an unrestricted research grant (120417) from Danone Nutricia Research. MAB was an employee of Danone Nutricia Research, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Furthermore, this does not alter our adherence to PLOS ONE policies on sharing data and materials.
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