The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity.
Mycobacterium tuberculosis
HLA-E
NK cells
donor-unrestricted T-cells
innate lymphoid cells
vaccine
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
07
01
2021
received:
30
11
2020
accepted:
07
01
2021
pubmed:
3
2
2021
medline:
26
10
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Vaccination strategies against mycobacteria, focusing mostly on classical T- and B-cells, have shown limited success, encouraging the addition of alternative targets. Classically restricted T-cells recognize antigens presented via highly polymorphic HLA class Ia and class II molecules, while donor-unrestricted T-cells (DURTs), with few exceptions, recognize ligands via genetically conserved antigen presentation molecules. Consequently, DURTs can respond to the same ligands across diverse human populations. DURTs can be activated either through cognate TCR ligation or via bystander cytokine signaling. TCR-driven antigen-specific activation of DURTs occurs upon antigen presentation via non-polymorphic molecules such as HLA-E, CD1, MR1, and butyrophilin, leading to the activation of HLA-E-restricted T-cells, CD1-restricted T-cells, mucosal-associated invariant T-cells (MAITs), and TCRγδ T-cells, respectively. NK cells and innate lymphoid cells (ILCs), which lack rearranged TCRs, are activated through other receptor-triggering pathways, or can be engaged through bystander cytokines, produced, for example, by activated antigen-specific T-cells or phagocytes. NK cells can also develop trained immune memory and thus could represent cells of interest to mobilize by novel vaccines. In this review, we summarize the latest findings regarding the contributions of DURTs, NK cells, and ILCs in anti-M tuberculosis, M leprae, and non-tuberculous mycobacterial immunity and explore possible ways in which they could be harnessed through vaccines and immunotherapies to improve protection against Mtb.
Identifiants
pubmed: 33529407
doi: 10.1111/imr.12948
pmc: PMC8154655
mid: NIHMS1661926
doi:
Substances chimiques
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-47Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141315
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127133
Pays : United States
Informations de copyright
© 2021 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
Références
J Immunol. 2006 Feb 15;176(4):2610-6
pubmed: 16456023
Am J Respir Crit Care Med. 2016 Aug 1;194(3):345-55
pubmed: 26882070
Lancet. 2013 Mar 23;381(9871):1021-8
pubmed: 23391465
PLoS One. 2013 Oct 03;8(10):e77334
pubmed: 24098583
J Immunol. 2010 Feb 1;184(3):1235-41
pubmed: 20026739
Eur J Immunol. 2007 Feb;37(2):549-65
pubmed: 17230439
Front Immunol. 2020 Jun 09;11:1136
pubmed: 32582206
J Immunol. 2008 Feb 1;180(3):1729-36
pubmed: 18209070
J Immunol. 2016 Aug 15;197(4):1100-1110
pubmed: 27412415
J Exp Med. 2004 Mar 1;199(5):649-59
pubmed: 14981115
Curr Opin Immunol. 2017 Oct;48:7-14
pubmed: 28750261
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7311-E7320
pubmed: 28807997
Tuberculosis (Edinb). 2019 May;116S:S11-S18
pubmed: 31072689
Front Cell Infect Microbiol. 2020 Mar 25;10:102
pubmed: 32269968
J Clin Invest. 2020 Jan 2;130(1):214-230
pubmed: 31763997
J Immunol. 2009 Aug 1;183(3):1644-56
pubmed: 19620317
J Immunol. 2009 Nov 15;183(10):6639-45
pubmed: 19864591
Clin Immunol. 2014 Dec;155(2):213-9
pubmed: 25451159
Infect Immun. 2018 Nov 20;86(12):
pubmed: 30201702
J Immunol. 2012 Jul 15;189(2):897-905
pubmed: 22711885
PLoS Pathog. 2009 Apr;5(4):e1000374
pubmed: 19360129
Hum Immunol. 1997 Jan;52(1):33-40
pubmed: 9021407
Antivir Ther. 2005;10(1):95-107
pubmed: 15751767
Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1685-90
pubmed: 8256920
Front Immunol. 2019 Sep 24;10:2282
pubmed: 31608066
J Immunol. 2019 Dec 1;203(11):2917-2927
pubmed: 31611259
Clin Immunol. 2008 Apr;127(1):1-6
pubmed: 18304877
Elife. 2015 Dec 10;4:
pubmed: 26652001
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10896-901
pubmed: 12960383
Front Immunol. 2018 Jun 19;9:1394
pubmed: 29971068
Tuberculosis (Edinb). 2016 May;98:13-20
pubmed: 27156613
Nat Immunol. 2010 Aug;11(8):701-8
pubmed: 20581831
Sci Rep. 2016 Sep 02;6:32320
pubmed: 27586092
Cell. 2018 Dec 13;175(7):1731-1743.e13
pubmed: 30503213
Infect Immun. 2012 Sep;80(9):3256-67
pubmed: 22778103
J Exp Med. 1993 Jul 1;178(1):1-16
pubmed: 8391057
Chem Biol. 2009 Jan 30;16(1):82-92
pubmed: 19171308
Eur J Immunol. 2015 Feb;45(2):442-51
pubmed: 25141829
Cell Mol Immunol. 2008 Jun;5(3):203-8
pubmed: 18582402
Nat Med. 2009 Mar;15(3):293-9
pubmed: 19219024
PLoS Pathog. 2016 Jun 15;12(6):e1005687
pubmed: 27304615
Cell. 2020 Oct 29;183(3):752-770.e22
pubmed: 33125891
Tuberculosis (Edinb). 2014 May;94(3):197-206
pubmed: 24629634
J Exp Med. 2011 Aug 29;208(9):1741-7
pubmed: 21807869
Nat Rev Immunol. 2013 Feb;13(2):101-17
pubmed: 23334244
Sci Adv. 2020 Feb 19;6(8):eaaz0374
pubmed: 32128419
Science. 1995 Jul 14;269(5221):227-30
pubmed: 7542404
Clin Exp Immunol. 2006 Aug;145(2):252-60
pubmed: 16879244
Infect Immun. 2002 Nov;70(11):6302-9
pubmed: 12379709
J Exp Med. 2013 Oct 21;210(11):2305-20
pubmed: 24101382
Nature. 2000 Apr 20;404(6780):884-8
pubmed: 10786796
Nature. 1989 Jun 15;339(6225):544-8
pubmed: 2471938
Nat Med. 2018 Feb;24(2):130-143
pubmed: 29334373
Nat Immunol. 2013 Nov;14(11):1137-45
pubmed: 24076636
J Immunol. 2007 Dec 15;179(12):8287-96
pubmed: 18056373
J Immunol. 1999 Jan 1;162(1):366-71
pubmed: 9886408
Vaccines (Basel). 2017 Dec 06;5(4):
pubmed: 29210987
Science. 2004 Jan 23;303(5657):527-31
pubmed: 14739458
Nature. 2018 Aug;560(7720):644-648
pubmed: 30135583
Lancet Respir Med. 2019 Sep;7(9):757-770
pubmed: 31416768
Immunity. 2016 Jan 19;44(1):32-45
pubmed: 26795251
Nat Immunol. 2016 Jun 21;17(7):765-74
pubmed: 27328006
Tuberculosis (Edinb). 2017 Jul;105:86-95
pubmed: 28610792
Cell Microbiol. 2012 Nov;14(11):1734-44
pubmed: 22788220
Immunology. 2015 Jul;145(3):443-53
pubmed: 25752900
J Exp Med. 2004 Dec 20;200(12):1559-69
pubmed: 15611286
JCI Insight. 2018 Oct 4;3(19):
pubmed: 30282828
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13230-5
pubmed: 21788486
Nat Rev Immunol. 2015 Oct;15(10):643-54
pubmed: 26388332
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10956-E10964
pubmed: 29158404
Front Cell Infect Microbiol. 2020 Aug 04;10:395
pubmed: 32850493
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5199-204
pubmed: 9560253
J Infect Dis. 2007 May 1;195(9):1361-4
pubmed: 17397008
Genes Immun. 2014 Apr-May;15(3):195-8
pubmed: 24500401
Immunol Cell Biol. 2018 May;96(5):507-525
pubmed: 29437263
J Infect Dis. 1992 Mar;165(3):506-12
pubmed: 1538155
J Immunol. 2017 Jun 15;198(12):4753-4763
pubmed: 28526681
J Clin Invest. 2014 Dec;124(12):5305-16
pubmed: 25384219
FEBS Lett. 2001 Dec 7;509(2):317-22
pubmed: 11741609
PLoS Pathog. 2013;9(10):e1003681
pubmed: 24130485
PLoS One. 2013 Aug 02;8(8):e71245
pubmed: 23936496
Clin Vaccine Immunol. 2015 Jul;22(7):761-8
pubmed: 25947144
Front Immunol. 2020 Feb 14;11:199
pubmed: 32117314
J Immunol. 2006 Feb 1;176(3):1386-93
pubmed: 16424165
Cell Immunol. 2013 Apr;282(2):106-12
pubmed: 23770719
Nat Rev Immunol. 2019 Sep;19(9):550-562
pubmed: 31114037
J Immunol. 2002 Apr 15;168(8):3933-40
pubmed: 11937549
Front Cell Infect Microbiol. 2020 Mar 24;10:120
pubmed: 32266170
Nature. 2020 Jan;577(7788):95-102
pubmed: 31894150
J Infect. 2020 Jul;81(1):57-71
pubmed: 32330526
Eur J Immunol. 1997 May;27(5):1164-9
pubmed: 9174606
PLoS Pathog. 2013 Jan;9(1):e1003119
pubmed: 23326234
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32
pubmed: 23307809
J Exp Med. 2019 Jan 7;216(1):133-151
pubmed: 30518599
PLoS One. 2014 Feb 26;9(2):e89612
pubmed: 24586912
Science. 2020 Feb 7;367(6478):
pubmed: 31919129
J Immunol. 2000 May 15;164(10):5019-22
pubmed: 10799855
PLoS Pathog. 2010 Feb 26;6(2):e1000789
pubmed: 20195465
Immunity. 2001 Dec;15(6):897-908
pubmed: 11754812
Int Immunol. 2009 Jul;21(7):779-91
pubmed: 19461127
Science. 1998 Oct 2;282(5386):121-5
pubmed: 9756476
J Immunol. 1998 May 1;160(9):4322-9
pubmed: 9574535
Eur J Immunol. 2018 Feb;48(2):293-305
pubmed: 29124751
Front Immunol. 2019 May 07;10:861
pubmed: 31134050
J Immunol. 2004 Jan 1;172(1):130-7
pubmed: 14688318
mBio. 2017 Oct 24;8(5):
pubmed: 29066547
Front Immunol. 2018 Nov 14;9:2656
pubmed: 30487801
J Immunol. 2015 Nov 15;195(10):4595-603
pubmed: 26466957
Sci Immunol. 2018 Jul 13;3(25):
pubmed: 30006464
Tuberculosis (Edinb). 2002;82(2-3):97-104
pubmed: 12356461
Sci Rep. 2017 Jul 4;7(1):4622
pubmed: 28676677
Chemistry. 2017 Jan 31;23(7):1694-1701
pubmed: 27925318
Nat Commun. 2018 Aug 22;9(1):3350
pubmed: 30135490
Mucosal Immunol. 2017 May;10(3):802-813
pubmed: 27759023
Sci Rep. 2016 Nov 28;6:37793
pubmed: 27892960
J Infect Dis. 2016 Feb 15;213(4):628-33
pubmed: 26374910
Nat Immunol. 2018 May;19(5):453-463
pubmed: 29632329
Science. 2016 Feb 12;351(6274):714-20
pubmed: 26797147
Immunity. 1998 Mar;8(3):341-51
pubmed: 9529151
Vaccine. 2017 Mar 7;35(10):1395-1402
pubmed: 28190740
Front Immunol. 2019 Feb 14;10:206
pubmed: 30853958
PLoS One. 2019 Jan 23;14(1):e0210252
pubmed: 30673723
N Engl J Med. 2019 Dec 19;381(25):2429-2439
pubmed: 31661198
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8995-9001
pubmed: 30992377
Immunol Rev. 2021 May;301(1):30-47
pubmed: 33529407
Mol Immunol. 2011 Feb;48(5):769-75
pubmed: 21190736
PLoS Pathog. 2014 Jan;10(1):e1003805
pubmed: 24391492
PLoS Pathog. 2010 Feb 26;6(2):e1000782
pubmed: 20195504
PLoS Pathog. 2015 Mar 24;11(3):e1004671
pubmed: 25803478
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):E3119-28
pubmed: 23898209
J Immunol. 2020 Nov 15;205(10):2861-2872
pubmed: 33020145
N Engl J Med. 2018 Jul 12;379(2):138-149
pubmed: 29996082
Nat Med. 2019 Feb;25(2):255-262
pubmed: 30664782
Immunohorizons. 2020 Jun 4;4(6):292-307
pubmed: 32499216
J Immunol. 2013 Nov 1;191(9):4499-503
pubmed: 24089190
Science. 2019 Oct 25;366(6464):
pubmed: 31649166
J Immunol. 2003 Apr 1;170(7):3696-706
pubmed: 12646635
J Infect Dis. 2001 Oct 15;184(8):1082-5
pubmed: 11574927
Eur J Immunol. 2014 Jan;44(1):195-203
pubmed: 24019201
Cell. 2018 Jan 11;172(1-2):176-190.e19
pubmed: 29328912
Front Immunol. 2017 Oct 11;8:1252
pubmed: 29075255
J Immunol. 2003 Aug 15;171(4):1961-8
pubmed: 12902499
Cell Chem Biol. 2018 Apr 19;25(4):392-402.e14
pubmed: 29398561
J Immunol. 2012 Aug 1;189(3):1285-93
pubmed: 22745375
Nat Commun. 2014 May 15;5:3866
pubmed: 24832684
Front Immunol. 2020 Sep 16;11:556695
pubmed: 33042140
Commun Biol. 2020 Oct 9;3(1):563
pubmed: 33037320
Oncotarget. 2015 Oct 6;6(30):28633-45
pubmed: 26416419
Am J Respir Crit Care Med. 2010 Sep 15;182(6):841-7
pubmed: 20508216
PLoS Pathog. 2019 Dec 6;15(12):e1008140
pubmed: 31809521
Genes Immun. 2017 Jan;18(1):8-14
pubmed: 27881839
PLoS Pathog. 2008 Dec;4(12):e1000239
pubmed: 19079582
Infect Immun. 2015 Dec 07;84(2):580-9
pubmed: 26644385
Vaccine. 2007 Aug 21;25(34):6313-20
pubmed: 17643559
Clin Vaccine Immunol. 2017 Feb 6;24(2):
pubmed: 27974398
PLoS One. 2015 Apr 20;10(4):e0124659
pubmed: 25894562
J Immunol. 2008 Aug 15;181(4):2292-302
pubmed: 18684918
Commun Biol. 2019 Jun 5;2:203
pubmed: 31231693
PLoS One. 2016 Mar 31;11(3):e0151721
pubmed: 27031950
J Infect. 2016 Mar;72(3):338-52
pubmed: 26724769
Sci Rep. 2015 Dec 08;5:17918
pubmed: 26643453
J Virol. 2019 Sep 30;93(20):
pubmed: 31375574
Infect Immun. 2012 Jun;80(6):2100-8
pubmed: 22409933
Clin Exp Immunol. 2019 May;196(2):167-177
pubmed: 30968409
Traffic. 2000 Apr;1(4):295-300
pubmed: 11208113
Immunol Cell Biol. 2018 Jul;96(6):573-587
pubmed: 29656544
PLoS Biol. 2010 Jun 29;8(6):e1000407
pubmed: 20613858
J Exp Med. 2009 Oct 26;206(11):2497-509
pubmed: 19808251
Int Immunol. 2003 Aug;15(8):915-25
pubmed: 12882829
J Exp Med. 1999 Jun 21;189(12):1973-80
pubmed: 10377193
Front Immunol. 2019 Oct 29;10:2542
pubmed: 31736965
J Immunol. 2004 Nov 1;173(9):5852-62
pubmed: 15494539
J Exp Med. 2013 Apr 8;210(4):729-41
pubmed: 23530121
Clin Immunol. 2008 May;127(2):214-24
pubmed: 18308638
PLoS Pathog. 2020 May 20;16(5):e1008585
pubmed: 32433713
Front Immunol. 2020 May 27;11:990
pubmed: 32536918
Mucosal Immunol. 2021 Jan;14(1):199-208
pubmed: 32811991
Nat Commun. 2016 Apr 12;7:11290
pubmed: 27068708
Immunol Cell Biol. 2018 Apr;96(4):379-389
pubmed: 29363172
J Biol Chem. 2003 Feb 14;278(7):5082-90
pubmed: 12411439
Nat Immunol. 2013 Jul;14(7):706-13
pubmed: 23727893
Science. 2019 Oct 18;366(6463):302-303
pubmed: 31624196
Front Immunol. 2015 Jan 05;5:657
pubmed: 25601861
Nat Immunol. 2019 Sep;20(9):1110-1128
pubmed: 31406380
Tuberculosis (Edinb). 2015 May;95(3):267-74
pubmed: 25837440
J Immunol. 2018 Jan 1;200(1):49-60
pubmed: 29150562
Front Immunol. 2019 Apr 26;10:913
pubmed: 31080452
J Leukoc Biol. 2014 Dec;96(6):1119-29
pubmed: 25139289
Eur J Immunol. 2017 Sep;47(9):1525-1534
pubmed: 28665555
PLoS One. 2012;7(12):e50923
pubmed: 23239994
J Exp Med. 2002 Dec 2;196(11):1473-81
pubmed: 12461082
J Immunol Res. 2016;2016:2695396
pubmed: 27699181
J Exp Med. 2000 Oct 2;192(7):965-76
pubmed: 11015438
J Immunol. 2012 Jan 1;188(1):302-10
pubmed: 22131332
Org Biomol Chem. 2019 Jan 31;17(5):1225-1237
pubmed: 30656346
J Exp Med. 1994 Sep 1;180(3):1171-6
pubmed: 8064234
Infect Immun. 2016 Aug 19;84(9):2449-62
pubmed: 27297390
J Immunol. 2006 Nov 15;177(10):7086-93
pubmed: 17082625
Nature. 1995 May 11;375(6527):155-8
pubmed: 7753173
J Immunol. 2002 Feb 1;168(3):1484-9
pubmed: 11801693
Immunogenetics. 2019 Jul;71(7):465-478
pubmed: 31123763
Eur J Immunol. 2020 Dec;50(12):2075-2091
pubmed: 32716529
PLoS One. 2013 Dec 31;8(12):e83474
pubmed: 24391773
PLoS Pathog. 2013 Aug;9(8):e1003501
pubmed: 23966854
Mucosal Immunol. 2017 Jul;10(4):1031-1042
pubmed: 27924822
J Immunol. 2005 Oct 1;175(7):4611-7
pubmed: 16177106
PLoS One. 2017 Nov 27;12(11):e0188288
pubmed: 29176828
J Immunol. 2020 Apr 15;204(8):2169-2176
pubmed: 32161099
Nature. 2019 Jun;570(7762):528-532
pubmed: 31168092
J Immunol. 2003 Mar 15;170(6):3154-61
pubmed: 12626573
Infect Immun. 2020 Dec 15;89(1):
pubmed: 33077620
J Immunol. 2009 Jun 1;182(11):7030-7
pubmed: 19454700
J Infect Dis. 2020 Aug 17;222(6):995-1007
pubmed: 32267943
J Immunol. 2002 Apr 1;168(7):3451-7
pubmed: 11907104
J Clin Invest. 2011 Jun;121(6):2493-503
pubmed: 21576820
J Immunol. 2008 Oct 1;181(7):4471-84
pubmed: 18802050
Eur J Immunol. 2006 Oct;36(10):2681-90
pubmed: 16981183
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6371-6378
pubmed: 30850538
Sci Rep. 2020 Aug 12;10(1):13579
pubmed: 32788608
Front Immunol. 2018 Nov 27;9:2709
pubmed: 30538700
Blood. 2011 Jan 27;117(4):1250-9
pubmed: 21084709
J Immunol. 1998 Jul 15;161(2):1045-54
pubmed: 9670986
Springer Semin Immunopathol. 2000;22(3):191-217
pubmed: 11116953
PLoS Pathog. 2017 May 5;13(5):e1006384
pubmed: 28475642