Alternating sources of perisomatic inhibition during behavior.

Animals CA1 Region, Hippocampal / physiology Cholecystokinin / metabolism Female Interneurons / physiology Male Mice, Inbred C57BL Mice, Transgenic Parvalbumins / metabolism Pyramidal Cells / physiology Synaptic Transmission / physiology
CA1 CB1 receptor GABA Sncg brain state cholecystokinin hippocampus inhibition interneuron locomotion parvalbumin

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
17 03 2021
Historique:
received: 15 09 2020
revised: 02 12 2020
accepted: 04 01 2021
pubmed: 3 2 2021
medline: 27 3 2021
entrez: 2 2 2021
Statut: ppublish

Résumé

Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior.

Identifiants

DOI: 10.1016/j.neuron.2021.01.003 PMID: 33529646 PMC: PMC7979482
pubmed: 33529646
pii: S0896-6273(21)00003-9
doi: 10.1016/j.neuron.2021.01.003
pmc: PMC7979482
mid: NIHMS1663102
pii:
doi:

Substances chimiques

Parvalbumins 0
Cholecystokinin 9011-97-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

997-1012.e9

Subventions

Organisme : NINDS NIH HHS
ID : P01 NS074972
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099457
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124047
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124867
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS069375
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071679
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS117795
Pays : United States
Organisme : NIMH NIH HHS
ID : UG3 MH120096
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007280
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081297
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS104590
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS110316
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111529
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Barna Dudok (B)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: bdudok@stanford.edu.

Peter M Klein (PM)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

Ernie Hwaun (E)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

Brian R Lee (BR)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Zizhen Yao (Z)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Olivia Fong (O)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

John C Bowler (JC)

Department of Neuroscience, Columbia University, New York, NY 10027, USA.

Satoshi Terada (S)

Department of Neuroscience, Columbia University, New York, NY 10027, USA.

Fraser T Sparks (FT)

Department of Neuroscience, Columbia University, New York, NY 10027, USA.

Gergely G Szabo (GG)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

Jordan S Farrell (JS)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

Jim Berg (J)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Tanya L Daigle (TL)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Bosiljka Tasic (B)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Jordane Dimidschstein (J)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Gord Fishell (G)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.

Attila Losonczy (A)

Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.

Hongkui Zeng (H)

Allen Institute for Brain Science, Seattle, WA 98109, USA.

Ivan Soltesz (I)

Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA1 de l'hippocampe › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Cholécystokinine › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › Parvalbumines › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Cellules › Neurones › Cellules pyramidales › Alternating sources of perisomatic inhibition...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Alternating sources of perisomatic inhibition...