Microtubules, actin and cytolinkers: how to connect cytoskeletons in the neuronal growth cone.
Actin
Axon growth
Axonal cytoskeleton
Cytolinker
Growth cone
Microtubule
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
received:
04
12
2020
revised:
12
01
2021
accepted:
16
01
2021
pubmed:
3
2
2021
medline:
4
6
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Cytolinkers ensure the integration of the different cytoskeleton components in the neuronal growth cone during development and in the course of axon regeneration. In neurons, an integrated skeleton guarantees appropriate function, and connectivity of high order circuits. Over the past years, several cytoskeleton regulatory proteins with actin-microtubule crosslinking activity have been identified. In neurons, the importance of spectrins, formins and other cytolinkers capable of coupling actin and microtubules has been extensively highlighted during axon outgrowth and guidance. In this Review, we discuss the current knowledge on cytolinkers specifically expressed in the neuronal growth cone of developing and regenerating axons.
Identifiants
pubmed: 33529653
pii: S0304-3940(21)00071-9
doi: 10.1016/j.neulet.2021.135693
pii:
doi:
Substances chimiques
Actins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
135693Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.