Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs.
lipid nanoparticle
liposome
mechanism
oligonucleotide
plasmid DNA
transfection
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Jan 2021
26 Jan 2021
Historique:
received:
30
12
2020
revised:
21
01
2021
accepted:
22
01
2021
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Nucleic acid and genetic medicines are increasingly being developed, owing to their potential to treat a variety of intractable diseases. A comprehensive understanding of the in vivo fate of these agents is vital for the rational design, discovery, and fast and straightforward development of the drugs. In case of intravascular administration of nucleic acids and genetic medicines, interaction with blood components, especially plasma proteins, is unavoidable. However, on the flip side, such interaction can be utilized wisely to manipulate the pharmacokinetics of the agents. In other words, plasma protein binding can help in suppressing the elimination of nucleic acids from the blood stream and deliver naked oligonucleotides and gene carriers into target cells. To control the distribution of these agents in the body, the ligand conjugation method is widely applied. It is also important to understand intracellular localization. In this context, endocytosis pathway, endosomal escape, and nuclear transport should be considered and discussed. Encapsulated nucleic acids and genes must be dissociated from the carriers to exert their activity. In this review, we summarize the in vivo fate of nucleic acid and gene medicines and provide guidelines for the rational design of drugs.
Identifiants
pubmed: 33530309
pii: pharmaceutics13020159
doi: 10.3390/pharmaceutics13020159
pmc: PMC7911509
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K12081
Références
Vaccines (Basel). 2019 Apr 24;7(2):
pubmed: 31022829
J Control Release. 2011 Dec 20;156(3):355-63
pubmed: 21756951
Mol Ther. 2010 Jul;18(7):1357-64
pubmed: 20461061
Biol Pharm Bull. 2018;41(6):944-950
pubmed: 29863083
Nucleosides Nucleotides Nucleic Acids. 2020;39(1-3):109-118
pubmed: 31617782
J Control Release. 2003 Aug 28;91(1-2):187-200
pubmed: 12932651
J Control Release. 2000 Mar 1;65(1-2):271-84
pubmed: 10699287
J Drug Target. 2017 Sep;25(8):704-714
pubmed: 28368667
Acta Biochim Pol. 2007;54(3):657-63
pubmed: 17713602
Pharmaceutics. 2019 May 22;11(5):
pubmed: 31121989
J Biomed Mater Res A. 2003 Dec 1;67(3):766-74
pubmed: 14613224
Nucleic Acids Res. 2020 Jun 4;48(10):5235-5253
pubmed: 32356888
Biol Pharm Bull. 2013;36(11):1807-13
pubmed: 24189424
FEBS Lett. 1979 May 15;101(2):229-32
pubmed: 446747
Mol Ther. 2002 Aug;6(2):219-26
pubmed: 12161188
J Healthc Eng. 2013;4(2):223-54
pubmed: 23778013
J Cell Biol. 2005 Jan 31;168(3):477-88
pubmed: 15668298
Drug Metab Dispos. 2007 Mar;35(3):460-8
pubmed: 17172312
Pharmacol Ther. 2020 Mar;207:107453
pubmed: 31836454
Mol Pharm. 2009 Jul-Aug;6(4):1170-9
pubmed: 19492848
J Control Release. 2015 Feb 28;200:97-105
pubmed: 25543000
Biochim Biophys Acta. 1996 Jun 11;1281(2):139-49
pubmed: 8664312
Nano Lett. 2020 Feb 12;20(2):1117-1123
pubmed: 32003222
Biomed Pharmacother. 2017 Mar;87:311-320
pubmed: 28064104
Nucleic Acids Res. 1979 Jun 25;6(8):2697-705
pubmed: 379828
J Control Release. 2017 Sep 10;261:10-22
pubmed: 28625673
Biophys Chem. 1984 May;19(3):211-25
pubmed: 6722274
J Pharmacol Exp Ther. 2005 Nov;315(2):484-93
pubmed: 16033911
Sci China Life Sci. 2020 Apr;63(4):485-500
pubmed: 31054052
Adv Drug Deliv Rev. 2015 Jun 29;87:46-51
pubmed: 25666165
Nat Biotechnol. 2019 Jun;37(6):640-650
pubmed: 31036929
Gene Ther. 1998 May;5(5):712-7
pubmed: 9797878
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3690-3
pubmed: 27268307
Proteomics. 2011 Aug;11(16):3349-58
pubmed: 21751361
Mol Ther. 2003 Aug;8(2):264-73
pubmed: 12907149
Nat Biotechnol. 2017 Mar;35(3):238-248
pubmed: 28244990
Adv Drug Deliv Rev. 2011 Mar 18;63(3):136-51
pubmed: 20441782
J Control Release. 2018 Apr 10;275:107-116
pubmed: 29452131
FEBS Lett. 2007 Jul 10;581(17):3164-70
pubmed: 17588566
Pharm Res. 2004 Jul;21(7):1223-8
pubmed: 15290863
J Control Release. 2017 Oct 10;263:68-78
pubmed: 28257990
J Cell Physiol. 2020 Jan;235(1):31-64
pubmed: 31215038
FEBS Lett. 1995 Jun 12;366(2-3):146-50
pubmed: 7789533
Cells. 2020 Sep 03;9(9):
pubmed: 32899119
Eur J Pharm Biopharm. 2020 Dec;157:85-96
pubmed: 33039547
Biochim Biophys Acta. 2001 Feb 9;1510(1-2):152-66
pubmed: 11342155
J Control Release. 2020 Jun 10;322:209-216
pubmed: 32194174
Curr Gene Ther. 2008 Jun;8(3):187-200
pubmed: 18537593
Mol Cancer Ther. 2002 Mar;1(5):347-55
pubmed: 12489851
Pharmaceutics. 2020 Sep 29;12(10):
pubmed: 33003609
J Control Release. 2020 Nov 10;327:467-476
pubmed: 32853732
Nucleic Acids Res. 2014 Jul;42(13):8796-807
pubmed: 24992960
Mol Ther Nucleic Acids. 2015 Jan 13;4:e220
pubmed: 25584900
Biomaterials. 2010 Aug;31(24):6355-62
pubmed: 20537380
Drug Deliv. 2017 Nov;24(1):906-917
pubmed: 28585867
Chembiochem. 2015 Apr 13;16(6):903-8
pubmed: 25786782
Biochim Biophys Acta. 1998 Jul 17;1372(2):272-82
pubmed: 9675310
Pharm Res. 1999 Aug;16(8):1273-9
pubmed: 10468031
Science. 1981 Dec 11;214(4526):1239-41
pubmed: 6795720
Methods Mol Biol. 2019;1943:333-346
pubmed: 30838627
Infect Immun. 1973 Jun;7(6):973-80
pubmed: 4351971
Pharm Res. 2003 Sep;20(9):1452-9
pubmed: 14567641
J Natl Cancer Inst. 1968 Aug;41(2):351-7
pubmed: 4299537
Hum Gene Ther. 2008 Oct;19(10):1009-20
pubmed: 18694297
Biomaterials. 2011 Sep;32(26):6194-203
pubmed: 21664689
J Am Chem Soc. 2020 Sep 2;142(35):14754-14771
pubmed: 32786803
Bioact Mater. 2020 Dec 26;6(7):1973-1987
pubmed: 33426371
Mol Ther Nucleic Acids. 2016 May 10;5:e319
pubmed: 27164023
J Pharm Pharmacol. 2019 Dec;71(12):1792-1799
pubmed: 31579949
Pharm Res. 2011 Apr;28(4):702-11
pubmed: 21116691
MMWR Morb Mortal Wkly Rep. 2020 Dec 18;69(50):1922-1924
pubmed: 33332292
Chem Pharm Bull (Tokyo). 2016;64(10):1431-1437
pubmed: 27725497
Biotechniques. 2000 Sep;29(3):610-4, 616, 618-9
pubmed: 10997275
Nature. 2004 Nov 11;432(7014):173-8
pubmed: 15538359
Pharmaceutics. 2020 Jul 09;12(7):
pubmed: 32659966
Biol Pharm Bull. 2013;36(6):892-9
pubmed: 23727912
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7413-7
pubmed: 2823261
Biochem Pharmacol. 2019 Aug;166:192-202
pubmed: 31129050
J Leukoc Biol. 2005 Jan;77(1):71-9
pubmed: 15496451
PLoS One. 2012;7(7):e41319
pubmed: 22844458
Semin Liver Dis. 1992 Nov;12(4):373-85
pubmed: 1465622
Cancer Res. 2010 Nov 15;70(22):9031-40
pubmed: 21045153
Hum Gene Ther. 1999 Jul 1;10(10):1735-7
pubmed: 10428218
J Mol Histol. 2021 Jan 2;:
pubmed: 33387144
Gene Ther. 2007 Jan;14(1):68-77
pubmed: 16915290
Int J Surg. 2020 Jun;78:185-193
pubmed: 32305533
Eur J Pharm Biopharm. 2020 Apr;149:45-57
pubmed: 32014491
J Pharmacol Toxicol Methods. 2020 Mar - Apr;102:106678
pubmed: 31981619
Pharmaceutics. 2020 Oct 26;12(11):
pubmed: 33114492
Pharmaceutics. 2021 Jan 18;13(1):
pubmed: 33477422
Enzymes. 2017;42:153-172
pubmed: 29054269
Bioconjug Chem. 2010 Jul 21;21(7):1280-7
pubmed: 20590107
Int J Pharm. 2017 Apr 15;521(1-2):361-364
pubmed: 28237886
Nucleic Acids Res. 2015 Jan;43(2):1204-15
pubmed: 25550434
Gene Ther. 2005 Apr;12(7):607-16
pubmed: 15616599
J Gene Med. 2011 Nov;13(11):632-43
pubmed: 22002583
Drug Metab Dispos. 2019 Oct;47(10):1164-1173
pubmed: 31350288
Toxicol Pathol. 2015 Jan;43(1):78-89
pubmed: 25385330
J Liposome Res. 2014 Jun;24(2):90-8
pubmed: 24188532
Theranostics. 2017 Jan 1;7(1):144-152
pubmed: 28042323
J Biol Chem. 1996 Apr 5;271(14):8481-7
pubmed: 8626549
Biochem Biophys Res Commun. 1986 May 29;137(1):244-9
pubmed: 3459459
Biomaterials. 2011 Jun;32(18):4306-16
pubmed: 21429576
Methods Mol Med. 2000;35:313-21
pubmed: 21390813
Mol Ther. 2002 Jun;5(6):731-8
pubmed: 12027557
Nat Rev Genet. 2020 Apr;21(4):255-272
pubmed: 32042148
Biomaterials. 2009 Apr;30(10):1971-7
pubmed: 19152975
Adv Drug Deliv Rev. 2020;154-155:163-175
pubmed: 32745496
J Drug Target. 2013 Nov;21(9):866-73
pubmed: 23952765
Jpn J Clin Oncol. 2014 Jun;44(6):515-25
pubmed: 24755547
Nucleic Acids Res. 1993 Aug 11;21(16):3857-65
pubmed: 8396239
Adv Drug Deliv Rev. 2015 Jun 29;87:3-14
pubmed: 25979468
Future Med Chem. 2011 Mar;3(3):339-65
pubmed: 21446846
FEBS Lett. 1999 Nov 5;460(3):472-6
pubmed: 10556519
Int J Mol Sci. 2020 Dec 22;22(1):
pubmed: 33374978
Dev Genet. 1993;14(4):296-304
pubmed: 7693387
Pharmaceutics. 2020 Oct 14;12(10):
pubmed: 33066531
Mol Ther. 2013 Jun;21(6):1118-30
pubmed: 23587924
Neoplasma. 2021 Jan;68(1):108-118
pubmed: 33147048
J Med Chem. 2016 Nov 10;59(21):9645-9667
pubmed: 27434100
J Control Release. 2016 Mar 28;226:57-65
pubmed: 26855051
Cancers (Basel). 2019 Oct 29;11(11):
pubmed: 31671769
Mol Ther. 2004 Mar;9(3):443-51
pubmed: 15006612
J Pharmacol Exp Ther. 1984 Apr;229(1):193-8
pubmed: 6707934
Biomaterials. 2009 May;30(14):2846-53
pubmed: 19232715
Langmuir. 2016 Feb 23;32(7):1799-807
pubmed: 26814663
Biomaterials. 2016 Jul;93:20-26
pubmed: 27061267
Org Biomol Chem. 2015 Mar 28;13(12):3757-65
pubmed: 25690587
Mol Ther. 2002 May;5(5 Pt 1):501-8
pubmed: 11991740
J Control Release. 2006 Apr 10;111(3):333-42
pubmed: 16488046
Biochim Biophys Acta. 1971 Jun 1;233(3):820-6
pubmed: 4107123
Nanomedicine. 2017 May;13(4):1377-1387
pubmed: 28038954
J Gene Med. 2005 Dec;7(12):1526-33
pubmed: 16170832
Chembiochem. 2002 Dec 2;3(12):1257-60
pubmed: 12465035
J Gene Med. 2005 May;7(5):657-63
pubmed: 15543529
Hum Gene Ther. 1997 Sep 1;8(13):1585-94
pubmed: 9322091
Biochem Biophys Res Commun. 2004 May 14;317(4):992-9
pubmed: 15094367
Science. 1990 Mar 23;247(4949 Pt 1):1465-8
pubmed: 1690918
Mol Ther. 2020 Mar 4;28(3):723-746
pubmed: 31972133
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14454-9
pubmed: 17726101
Leukemia. 2008 Aug;22(8):1519-28
pubmed: 18496560
Mol Ther. 2010 Apr;18(4):707-14
pubmed: 20104210
Nucleic Acids Res. 2015 Oct 30;43(19):e128
pubmed: 26101258
Biochim Biophys Acta. 1969 Oct 14;193(1):82-91
pubmed: 5388894
Cell Death Differ. 2018 Dec;25(12):2195-2208
pubmed: 29795334
FEBS Lett. 2016 Aug;590(16):2671-80
pubmed: 27317902
MMWR Morb Mortal Wkly Rep. 2021 Jan 01;69(5152):1653-1656
pubmed: 33382675
Nucleic Acids Res. 2017 Nov 2;45(19):10969-10977
pubmed: 28981809
Bioconjug Chem. 2018 Jul 18;29(7):2478-2488
pubmed: 29898368
ACS Appl Mater Interfaces. 2020 Jul 29;12(30):34011-34020
pubmed: 32667806
Exp Cell Res. 1999 Dec 15;253(2):713-22
pubmed: 10585295
ACS Nano. 2019 Oct 22;13(10):11008-11021
pubmed: 31503443
Biochem Biophys Res Commun. 2008 Aug 1;372(3):383-7
pubmed: 18445481
Nucleic Acids Res. 2019 Feb 20;47(3):1110-1122
pubmed: 30566688
Gene Ther. 1999 Jul;6(7):1258-66
pubmed: 10455434
Mol Ther. 2008 Apr;16(4):734-40
pubmed: 18362929
Adv Drug Deliv Rev. 2017 Feb;110-111:80-101
pubmed: 27539561
Protein Pept Lett. 2014;21(10):1025-30
pubmed: 24975671
Pharmaceutics. 2020 Nov 09;12(11):
pubmed: 33182398
Biophys J. 1990 Jul;58(1):1-12
pubmed: 2383626
Nat Commun. 2016 Jun 14;7:11856
pubmed: 27297211
N Engl J Med. 2017 Apr 13;376(15):1430-1440
pubmed: 28306389
World J Gastrointest Oncol. 2020 Feb 15;12(2):173-181
pubmed: 32104548
Mol Pharm. 2016 Sep 6;13(9):3141-52
pubmed: 27458925
Cancer Sci. 2014 Aug;105(8):1049-55
pubmed: 24850474
Exp Cell Res. 1995 Nov;221(1):103-10
pubmed: 7589234
J Microsc. 2010 Apr 1;238(1):1-20
pubmed: 20384833
J Biosci Bioeng. 2011 Nov;112(5):508-10
pubmed: 21889402
J Am Chem Soc. 2014 Dec 10;136(49):16958-61
pubmed: 25434769
Nat Biotechnol. 2010 Feb;28(2):172-6
pubmed: 20081866
Nat Nanotechnol. 2011 Oct 23;6(12):815-23
pubmed: 22020122
Hepatology. 2002 Jun;35(6):1314-9
pubmed: 12029616
Eur J Pharm Sci. 2002 Nov;17(3):131-8
pubmed: 12393140
J Pharm Sci. 2014 Feb;103(2):557-66
pubmed: 24347396
Biomater Sci. 2018 May 1;6(5):1031-1039
pubmed: 29557458
Biol Pharm Bull. 2020;43(9):1324-1330
pubmed: 32879206
J Biol Chem. 2006 Feb 10;281(6):3544-51
pubmed: 16326716
Gene Ther. 2011 Apr;18(4):326-33
pubmed: 21179173
Adv Drug Deliv Rev. 2021 Jan 2;170:83-112
pubmed: 33400957
Neurochem Int. 2021 Mar;144:104955
pubmed: 33412233
Drug Deliv. 2017 Nov;24(1):737-744
pubmed: 28446052
Nucleic Acids Res. 1996 Oct 15;24(20):4063-70
pubmed: 8918813
Cancer Res. 1997 Jul 1;57(13):2681-6
pubmed: 9205077
Pharmaceutics. 2018 Dec 01;10(4):
pubmed: 30513734
Nat Cell Biol. 2001 May;3(5):473-83
pubmed: 11331875
Curr Opin Cell Biol. 2003 Aug;15(4):414-22
pubmed: 12892781
Gene Ther. 1999 Apr;6(4):482-97
pubmed: 10476208
Mol Ther. 2005 Sep;12(3):468-74
pubmed: 15963763
Expert Rev Vaccines. 2016;15(3):313-29
pubmed: 26707950
J Drug Target. 2000;7(6):439-52
pubmed: 10758914
Mol Pharm. 2012 Jul 2;9(7):1962-70
pubmed: 22670625
Nucleic Acids Res. 2020 Dec 2;48(21):11827-11844
pubmed: 32808038
J Cell Biol. 2017 Jan 2;216(1):53-63
pubmed: 27920217
Gene Ther. 2001 May;8(9):677-86
pubmed: 11406762
Mol Ther. 2008 Apr;16(4):726-733
pubmed: 28178464
Bioorg Med Chem. 2016 Jan 1;24(1):26-32
pubmed: 26678173
Gene Ther. 2011 Jan;18(1):82-7
pubmed: 20739959
Nat Rev Genet. 2015 Sep;16(9):543-52
pubmed: 26281785
Nucleic Acids Res. 2007;35(2):687-700
pubmed: 17182632
Mol Pharm. 2015 Dec 7;12(12):4277-89
pubmed: 26465978
J Pharm Pharmacol. 2003 Apr;55(4):453-60
pubmed: 12803766
Adv Drug Deliv Rev. 2020;154-155:37-63
pubmed: 32526452
Nucleic Acid Ther. 2018 Feb;28(1):50-57
pubmed: 29360004
Nucleic Acid Ther. 2018 Jun;28(3):178-193
pubmed: 29883296
Gene Ther. 2002 Jul;9(13):850-8
pubmed: 12080379
Mol Ther. 2020 Mar 4;28(3):709-722
pubmed: 31968213
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
Nucleic Acids Res. 2015 Mar 11;43(5):2927-45
pubmed: 25712094
Gene Ther. 2004 Apr;11(8):711-21
pubmed: 14724672
J Biol Chem. 2005 Apr 1;280(13):12255-61
pubmed: 15661732
Biomacromolecules. 2010 Oct 11;11(10):2700-6
pubmed: 20795699
Int J Pharm. 2007 Sep 5;342(1-2):33-9
pubmed: 17566677
Nucleic Acids Res. 2017 Dec 1;45(21):12388-12400
pubmed: 29069408
Nucleic Acids Res. 2014 Apr;42(8):4882-91
pubmed: 24550163
Biochemistry. 2018 Apr 10;57(14):2061-2064
pubmed: 29589907
Biochim Biophys Acta. 1995 May 4;1235(2):289-95
pubmed: 7756337
Curr Gene Ther. 2007 Oct;7(5):334-46
pubmed: 17979680
J Biomed Mater Res A. 2019 May;107(5):978-990
pubmed: 30665262
Expert Opin Drug Deliv. 2011 Mar;8(3):343-57
pubmed: 21291354
Annu Rev Med. 2012;63:35-61
pubmed: 22248320
Antisense Res Dev. 1995 Winter;5(4):279-87
pubmed: 8746777
Nat Biotechnol. 2007 Oct;25(10):1149-57
pubmed: 17873866
Pharmaceutics. 2020 Apr 10;12(4):
pubmed: 32290201
Annu Rev Biochem. 1972;41:753-76
pubmed: 4563442
Drug Metab Dispos. 1997 Nov;25(11):1272-81
pubmed: 9351904
Annu Rev Med. 2020 Jan 27;71:47-58
pubmed: 31412220
Gene Ther. 2004 Apr;11(8):675-82
pubmed: 14724673
Gene Ther. 2000 Feb;7(4):292-9
pubmed: 10694809
Biol Pharm Bull. 2014;37(2):212-6
pubmed: 24492718
J Control Release. 2004 Oct 19;99(3):445-56
pubmed: 15451602
Methods Mol Biol. 2018;1828:481-487
pubmed: 30171561
J Biomed Nanotechnol. 2014 Jan;10(1):67-80
pubmed: 24724499
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):172-182
pubmed: 27349594
Mol Ther. 2006 Apr;13(4):786-94
pubmed: 16364692
J Control Release. 2020 Jun 10;322:357-374
pubmed: 32243981
J Gene Med. 2018 May;20(5):e3015
pubmed: 29575374
Vaccines (Basel). 2019 Dec 06;7(4):
pubmed: 31817794
Biosci Rep. 2017 Nov 29;37(6):
pubmed: 29054961
Expert Opin Drug Deliv. 2016 Jul;13(7):1015-27
pubmed: 26878086
J Control Release. 2016 Dec 28;244(Pt A):108-121
pubmed: 27871992
Int J Nanomedicine. 2018 Apr 16;13:2309-2320
pubmed: 29713163
Mol Ther Nucleic Acids. 2018 Mar 2;10:45-54
pubmed: 29499955
Colloids Surf B Biointerfaces. 2016 May 1;141:170-178
pubmed: 26852100
Autophagy. 2013 May;9(5):667-82
pubmed: 23422759
Mol Ther Nucleic Acids. 2020 Sep 4;21:242-250
pubmed: 32590173
Mol Ther. 2017 Jul 5;25(7):1710-1717
pubmed: 28641935
J Pharmacol Exp Ther. 2006 Aug;318(2):828-34
pubmed: 16670348
J Drug Target. 2015 Jun;23(5):427-35
pubmed: 25673263
Pharmaceutics. 2020 Jun 12;12(6):
pubmed: 32545479
J Liposome Res. 2006;16(3):237-47
pubmed: 16952878
Pharm Res. 1995 Jun;12(6):825-30
pubmed: 7667185
Langmuir. 2011 Dec 20;27(24):15048-53
pubmed: 22043822
ACS Nano. 2020 Jun 23;14(6):7216-7226
pubmed: 32379425
ACS Nano. 2013 Jun 25;7(6):5376-84
pubmed: 23647441
Nucleic Acids Res. 2019 Jul 9;47(12):6029-6044
pubmed: 31127296
J Phys Chem B. 2015 Jul 16;119(28):8698-706
pubmed: 26087393
Pediatr Neurol. 2019 Nov;100:3-11
pubmed: 31371124
Mol Ther. 2005 Feb;11(2):257-66
pubmed: 15668137
Eur J Immunol. 2016 Feb;46(2):269-80
pubmed: 26626159
Mol Ther Nucleic Acids. 2020 Jun 5;20:534-544
pubmed: 32330871
Pharm Res. 2007 Sep;24(9):1772-87
pubmed: 17554608
Gene Ther. 2008 Sep;15(17):1193-9
pubmed: 18401434
Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063
pubmed: 27981708
Arch Med Res. 2003 Jul-Aug;34(4):247-68
pubmed: 12957520
Nucleic Acids Res. 2019 Jan 25;47(2):953-969
pubmed: 30462278
Hum Gene Ther. 2018 Dec;29(12):1376-1386
pubmed: 29926749
Sci Rep. 2018 Aug 7;8(1):11842
pubmed: 30087399
Acta Pharm Sin B. 2020 Nov;10(11):2075-2109
pubmed: 33304780
Mol Ther Nucleic Acids. 2016 Aug 09;5(8):e344
pubmed: 27504598
Hum Gene Ther. 2001 May 20;12(8):861-70
pubmed: 11387052
J Control Release. 2007 Jan 22;117(1):130-6
pubmed: 17113176
Hum Vaccin Immunother. 2017 Jun 3;13(6):1-6
pubmed: 28272989
Nucleic Acids Res. 2010 Jan;38(1):e3
pubmed: 19854938
Biochem J. 2002 Aug 15;366(Pt 1):333-41
pubmed: 12030844
Eur J Pharm Biopharm. 2009 Feb;71(2):303-9
pubmed: 18835442
Curr Gene Ther. 2005 Feb;5(1):25-35
pubmed: 15638709
Chem Pharm Bull (Tokyo). 2020;68(7):603-612
pubmed: 32611997
Int J Nanomedicine. 2020 Feb 05;15:675-704
pubmed: 32103936
Gene Ther. 1997 Sep;4(9):950-60
pubmed: 9349432
Annu Rev Neurosci. 2019 Jul 8;42:385-406
pubmed: 31283897
Hum Gene Ther. 2012 Jan;23(1):128-37
pubmed: 21797718
J Control Release. 2000 May 15;66(2-3):255-69
pubmed: 10742585
Eur J Pharm Sci. 2016 Oct 10;93:493-503
pubmed: 27593989
Drug Metab Pharmacokinet. 2003;18(4):230-7
pubmed: 15618740
Mol Ther. 2004 Oct;10(4):719-29
pubmed: 15451456
Int J Pharm. 2018 Sep 5;548(1):173-181
pubmed: 29969708
ACS Biomater Sci Eng. 2015 Sep 14;1(9):834-844
pubmed: 33445261
Drug Metab Dispos. 2003 Nov;31(11):1419-28
pubmed: 14570775
PLoS One. 2016 Jan 29;11(1):e0148233
pubmed: 26824850
Curr Opin Biotechnol. 2010 Oct;21(5):640-5
pubmed: 20674331
J Clin Pharmacol. 2020 Jan;60(1):37-49
pubmed: 31322739
Nucleic Acid Ther. 2016 Aug;26(4):223-35
pubmed: 27031383
Mol Pharm. 2018 Jun 4;15(6):2069-2083
pubmed: 29767984
J Gene Med. 2019 Jul;21(7):e3088
pubmed: 30938916
Pharmazie. 2012 May;67(5):400-5
pubmed: 22764571
Anal Biochem. 2011 Dec 15;419(2):180-9
pubmed: 21867671
Pharm Res. 1992 Oct;9(10):1235-42
pubmed: 1448419
Gene Ther. 2000 Apr;7(7):541-7
pubmed: 10819568
Biochim Biophys Acta. 2005 May 20;1669(2):155-63
pubmed: 15893518
Circulation. 2019 Jan 2;139(1):78-96
pubmed: 30586693
ACS Chem Biol. 2015 May 15;10(5):1181-7
pubmed: 25730476
Theranostics. 2017 May 12;7(7):1990-2002
pubmed: 28638484
J Clin Pharmacol. 2019 Nov 27;:
pubmed: 31777097
Bioconjug Chem. 2015 Aug 19;26(8):1451-5
pubmed: 26011654
Cell Metab. 2018 Apr 3;27(4):714-739
pubmed: 29617640
Signal Transduct Target Ther. 2020 Jun 19;5(1):101
pubmed: 32561705
Gene Ther. 2016 Oct;23(10):734-742
pubmed: 27367840
Biol Pharm Bull. 2010;33(9):1627-32
pubmed: 20823586
J Clin Invest. 2007 Mar;117(3):539-48
pubmed: 17332881
Chem Pharm Bull (Tokyo). 2017;65(7):642-648
pubmed: 28674337
Pharm Res. 2000 Mar;17(3):306-13
pubmed: 10801219
Science. 2003 Oct 17;302(5644):415-9
pubmed: 14564000
Nucleic Acids Res. 2016 Mar 18;44(5):2093-109
pubmed: 26553810
J Cell Biol. 1998 Apr 6;141(1):85-99
pubmed: 9531550
Toxicol Rep. 2020 Dec 26;8:148-154
pubmed: 33437656
EMBO J. 1982;1(7):841-5
pubmed: 6329708
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2702-6
pubmed: 1849273
Biol Pharm Bull. 2006 Jul;29(7):1521-3
pubmed: 16819204
Pharmaceutics. 2015 Sep 21;7(3):344-62
pubmed: 26402694
Int J Pharm. 2012 Feb 28;423(2):428-34
pubmed: 22197775
Nat Commun. 2015 Aug 10;6:7969
pubmed: 26258894
Ann Neurol. 2020 Mar;87(3):339-346
pubmed: 31943325
J Pharmacokinet Biopharm. 1985 Dec;13(6):609-31
pubmed: 3938814
Nucleic Acids Res. 2007;35(5):1533-43
pubmed: 17287293
Nucleic Acid Ther. 2017 Apr;27(2):70-77
pubmed: 28080221
Nat Biotechnol. 2017 Mar;35(3):230-237
pubmed: 28244996
PLoS One. 2020 Feb 6;15(2):e0228203
pubmed: 32027678
Sci Adv. 2018 Oct 17;4(10):eaat3386
pubmed: 30345352
Theranostics. 2019 Feb 28;9(6):1580-1598
pubmed: 31037125
J Pharm Sci. 2008 Jan;97(1):225-36
pubmed: 17721945
Biochem Biophys Res Commun. 1991 Aug 30;179(1):280-5
pubmed: 1883357
Pharmaceutics. 2020 Sep 29;12(10):
pubmed: 33003468
Gene Ther. 2008 Aug;15(15):1107-15
pubmed: 18496575
J Control Release. 2021 Feb 10;330:812-820
pubmed: 33417983
Adv Drug Deliv Rev. 2020;154-155:79-101
pubmed: 32574575
Curr Top Microbiol Immunol. 2005;285:67-108
pubmed: 15609501
Amyloid. 2020 Mar;27(1):45-51
pubmed: 31648569
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6
pubmed: 9874777
Front Bioeng Biotechnol. 2019 Dec 17;7:415
pubmed: 31921819
J Control Release. 2019 May 28;302:42-53
pubmed: 30926479
J Pharmacol Exp Ther. 2016 May;357(2):320-30
pubmed: 26907624
Nucleic Acids Res. 2011 Jun;39(11):4795-807
pubmed: 21345934
Somat Cell Mol Genet. 2002 Nov;27(1-6):85-95
pubmed: 12774943
Biochem Biophys Res Commun. 2019 Mar 12;510(3):427-434
pubmed: 30732855
Mol Ther Nucleic Acids. 2012 Sep 18;1:e45
pubmed: 23344237
Mol Ther. 2003 Feb;7(2):254-61
pubmed: 12597914
Ultrasound Med Biol. 2013 Dec;39(12):2393-405
pubmed: 24063956
Biol Pharm Bull. 2011;34(9):1514-7
pubmed: 21881243
Exp Cell Res. 1997 Feb 1;230(2):293-302
pubmed: 9024788
Pharmaceutics. 2020 Dec 22;13(1):
pubmed: 33374908