NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations.
NASH
atherosclerosis
diabetes
exercise
lifestyle
liver
metabolic syndrome
nutrition
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
26 Jan 2021
26 Jan 2021
Historique:
received:
30
12
2020
revised:
21
01
2021
accepted:
21
01
2021
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative. It is, however, likely that common mechanisms contribute to the development of CVD and NAFLD, with lifestyle factors such as smoking, sedentary lifestyle with poor nutrition habits and physical inactivity being major candidates. These behavioral factors, on a predisposing genetic background, trigger changes in gut microbiota, inflammation, dyslipidemia and oxidative stress, leading to metabolic syndrome, diabetes and obesity as well as atherosclerosis. Treatment options to counteract both the progression and development of CVD and NAFLD include lifestyle interventions, optimal medical therapy of comorbid conditions and, as final possibility, bariatric surgery. As no causal pharmacotherapy of NAFLD is available, further research is urgently needed to address the unmet need of a growing population with NAFLD and CVD.
Identifiants
pubmed: 33530440
pii: jcm10030467
doi: 10.3390/jcm10030467
pmc: PMC7865665
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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