Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region.
CDR grafting
modeling
nanobody framework
nanobody humanization
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
26 01 2021
26 01 2021
Historique:
received:
21
12
2020
revised:
21
01
2021
accepted:
24
01
2021
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
23
7
2021
Statut:
epublish
Résumé
In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially humanized signature, the transformation of the
Identifiants
pubmed: 33530572
pii: biom11020163
doi: 10.3390/biom11020163
pmc: PMC7911018
pii:
doi:
Substances chimiques
Single-Domain Antibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development Program of China
ID : 2019YFA0905600
Organisme : Javna Agencija za Raziskovalno dejavnost Republike Slovenije
ID : ARRS/N4-0046
Organisme : Javna Agencija za Raziskovalno dejavnost Republike Slovenije
ID : ARRS/J4-9322
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 18510
Références
PeerJ. 2020 Mar 6;8:e8408
pubmed: 32185102
Electrophoresis. 1997 Dec;18(15):2714-23
pubmed: 9504803
PLoS One. 2019 May 2;14(5):e0216083
pubmed: 31048885
Proteins. 2018 Jul;86(7):697-706
pubmed: 29569425
J Mol Biol. 2008 Oct 10;382(3):779-89
pubmed: 18687338
J Mol Biol. 2016 Feb 22;428(4):720-725
pubmed: 26410586
Nat Struct Biol. 1996 Sep;3(9):803-11
pubmed: 8784355
Microb Cell Fact. 2015 Sep 02;14:125
pubmed: 26330219
J Chem Phys. 2007 Jan 7;126(1):014101
pubmed: 17212484
J Mol Biol. 2005 Sep 23;352(3):597-607
pubmed: 16095608
Nat Struct Mol Biol. 2010 Apr;17(4):398-402
pubmed: 20228801
Dev Comp Immunol. 2012 Jan;36(1):150-6
pubmed: 21767565
Chem Commun (Camb). 2019 Nov 19;55(93):14043-14046
pubmed: 31690899
Elife. 2016 Jul 19;5:
pubmed: 27434673
Molecules. 2011 May 03;16(5):3675-700
pubmed: 21540796
Bioinformatics. 2007 Dec 15;23(24):3397-9
pubmed: 17933856
Structure. 1999 Apr 15;7(4):361-70
pubmed: 10196124
Phys Chem Chem Phys. 2018 Jan 31;20(5):3438-3444
pubmed: 29328338
Protein Eng Des Sel. 2014 Jun;27(6):191-8
pubmed: 24742504
Bioinformatics. 2013 Apr 1;29(7):845-54
pubmed: 23407358
Sci Rep. 2016 Oct 10;6:34869
pubmed: 27721441
Protein Eng Des Sel. 2018 Jul 1;31(7-8):267-275
pubmed: 30053276
Sci Rep. 2017 Aug 15;7(1):8200
pubmed: 28811609
J Mol Biol. 2005 Jul 1;350(1):112-25
pubmed: 15913651
J Biol Chem. 2009 Jan 30;284(5):3273-3284
pubmed: 19010777
Protein Expr Purif. 2011 Sep;79(1):111-4
pubmed: 21421053
Nature. 2003 Aug 14;424(6950):783-8
pubmed: 12917687
Nat Biotechnol. 2000 Aug;18(8):852-6
pubmed: 10932154
Protein Eng Des Sel. 2014 Feb;27(2):29-39
pubmed: 24398633
Protein Eng Des Sel. 2009 Apr;22(4):273-80
pubmed: 19196718
Microb Cell Fact. 2014 Sep 16;13:140
pubmed: 25223348
Nat Biotechnol. 2004 Sep;22(9):1161-5
pubmed: 15300256
Nat Biotechnol. 2004 Dec;22(12):1567-72
pubmed: 15558047
J Biol Chem. 2002 Jun 28;277(26):23645-50
pubmed: 11960990
J Mol Biol. 1996 Jun 28;259(5):957-69
pubmed: 8683598
Mol Immunol. 1997 Nov-Dec;34(16-17):1121-31
pubmed: 9566760
Proteins. 2010 Jun;78(8):1950-8
pubmed: 20408171
J Biol Chem. 2001 Jul 13;276(28):26285-90
pubmed: 11342547
J Immunol. 2010 May 15;184(10):5696-704
pubmed: 20404276