Custodiol-MP for ex vivo lung perfusion - A comparison in a porcine model of donation after circulatory determination of death.

Custodiol-MP Lung transplant affordable artificial organs animal models artificial lung ex vivo lung perfusion mechanical ventilation organ preservation pulmonary function

Journal

The International journal of artificial organs
ISSN: 1724-6040
Titre abrégé: Int J Artif Organs
Pays: United States
ID NLM: 7802649

Informations de publication

Date de publication:
Feb 2022
Historique:
pubmed: 4 2 2021
medline: 20 1 2022
entrez: 3 2 2021
Statut: ppublish

Résumé

Ex vivo lung perfusion (EVLP) is an established technique to evaluate and eventually recondition lungs prior to transplantation. Custodiol-MP (C-MP) solution is a new solution, designed for clinical machine perfusion, that has been used for kidneys. The aim of this study was to compare the effects of EVLP with Custodiol-MP on lung functional outcomes to the gold standard of EVLP with Steen Solution™. In a porcine EVLP model of DCDD (Donation after Circulatory Determination of Death), lungs were perfused with Steen Solution™ (SS, Oxygenation capacity differed significantly between groups (averaged over 4 h: SS 274 ± 178 mmHg; C-MP 284 ± 151 mmHg

Identifiants

pubmed: 33530837
doi: 10.1177/0391398821990663
pmc: PMC8777315
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

162-173

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Auteurs

Katharina Kalka (K)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

Zoe Keldenich (Z)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

Henning Carstens (H)

Department of Cardiothoracic Surgery, Center of Cardiology, University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany.

Björn Walter (B)

Institut für Physiologische Chemie, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany.

Ursula Rauen (U)

Institut für Physiologische Chemie, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany.

Arjang Ruhparwar (A)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

Alexander Weymann (A)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

Markus Kamler (M)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

Gerald Reiner (G)

Department of Veterinary Clinical Sciences, Swine Clinic, Justus-Liebig-University, Giessen, Hessen, Germany.

Achim Koch (A)

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic Transplantation, West German Heart Center, University Hospital Essen, Essen, Germany.

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Classifications MeSH