Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer.
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
02
12
2020
revised:
22
12
2020
accepted:
23
12
2020
pubmed:
4
2
2021
medline:
28
10
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
The mammalian skin is essential to protect the organism from external damage while at the same time enabling communication with the environment. Aging compromises skin function and regeneration, which is further exacerbated by external influences, such as UVR from the sun. Aging and UVR are also major risk factors contributing to the development of skin cancer. Whereas aging research traditionally has focused on the role of DNA damage and metabolic and stress pathways, less is known about how aging affects tissue architecture and cell dynamics in skin homeostasis and regeneration and whether changes in these processes promote skin cancer. This review highlights how key regulators of cell polarity and adhesion affect epidermal mechanics, tissue architecture, and stem cell dynamics in skin aging and cancer.
Identifiants
pubmed: 33531135
pii: S0022-202X(20)32410-6
doi: 10.1016/j.jid.2020.12.012
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1017-1023Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.