[Bronchial thermoplasty for severe asthma].
Place de thermoplastie bronchique dans la prise en charge de l’asthme sévère.
Asthme sévère
Bronchial thermoplasty
Bronchoscopie interventionnelle
Interventional pulmonology
Severe asthma
Thermoplastie bronchique
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
27
08
2020
accepted:
13
10
2020
pubmed:
4
2
2021
medline:
18
9
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Bronchial thermoplasty has been developed over the past fifteen years and is the first endoscopic technique approved in the management of severe asthma. This procedure uses radiofrequency applied to the airway wall to target bronchial smooth muscle. Patients treated in randomized controlled trials have experienced significant decreases in the use of rescue medications, urgent care visits, and exacerbations rate. The lack of reliable predictive markers of response to this expensive, minimally-invasive technique currently makes it a last-line treatment option. We review the principles and supposed mechanisms of action of this treatment, the results from the main trials and clinical registry data and discuss the place of bronchial thermoplasty in the current management of severe asthma. We also discuss perspectives to better characterize the mechanisms of action and identify the responder phenotype, the main challenge of current studies.
Identifiants
pubmed: 33531186
pii: S0761-8425(21)00003-6
doi: 10.1016/j.rmr.2021.01.002
pii:
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
289-296Informations de copyright
Copyright © 2021 SPLF. Published by Elsevier Masson SAS. All rights reserved.