Structural basis for ligand recognition of the neuropeptide Y Y

Benzamides / pharmacology Crystallography, X-Ray HEK293 Cells Humans Mutagenesis / genetics Peptide Hormones / pharmacology Piperazines / pharmacology Protein Structure, Secondary Pyridines / pharmacology Receptors, Neuropeptide Y / genetics X-Ray Diffraction

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
02 02 2021
Historique:
received: 01 06 2020
accepted: 08 01 2021
entrez: 3 2 2021
pubmed: 4 2 2021
medline: 2 3 2021
Statut: epublish

Résumé

The human neuropeptide Y (NPY) Y

Identifiants

DOI: 10.1038/s41467-021-21030-9 PMID: 33531491 PMC: PMC7854658
pubmed: 33531491
doi: 10.1038/s41467-021-21030-9
pii: 10.1038/s41467-021-21030-9
pmc: PMC7854658
doi:

Substances chimiques

Benzamides 0
JNJ-31020028 0
Peptide Hormones 0
Piperazines 0
Pyridines 0
Receptors, Neuropeptide Y 0
neuropeptide Y2 receptor 0
benzamide 6X80438640
pyridine NH9L3PP67S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

737

Références

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Auteurs

Tingting Tang (T)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.

Christin Hartig (C)

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, D 04103, Leipzig, Germany.

Qiuru Chen (Q)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.
School of Life Science and Technology, ShanghaiTech University, 393 Hua Xia Zhong Road, Shanghai, 201210, China.

Wenli Zhao (W)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.

Anette Kaiser (A)

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, D 04103, Leipzig, Germany.

Xuefeng Zhang (X)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.
ORCID: 0000-0002-5222-7042

Hui Zhang (H)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.

Honge Qu (H)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China.
School of Life Science and Technology, ShanghaiTech University, 393 Hua Xia Zhong Road, Shanghai, 201210, China.

Cuiying Yi (C)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.

Limin Ma (L)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.

Shuo Han (S)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China.
ORCID: 0000-0003-0760-0183

Qiang Zhao (Q)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China. zhaoq@simm.ac.cn.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. zhaoq@simm.ac.cn.
CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, 100101, China. zhaoq@simm.ac.cn.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. zhaoq@simm.ac.cn.

Annette G Beck-Sickinger (AG)

Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstr. 34, D 04103, Leipzig, Germany. abeck-sickinger@uni-leipzig.de.
ORCID: 0000-0003-4560-8020

Beili Wu (B)

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai, 201203, China. beiliwu@simm.ac.cn.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. beiliwu@simm.ac.cn.
School of Life Science and Technology, ShanghaiTech University, 393 Hua Xia Zhong Road, Shanghai, 201210, China. beiliwu@simm.ac.cn.
CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, 100101, China. beiliwu@simm.ac.cn.
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. beiliwu@simm.ac.cn.
ORCID: 0000-0002-1936-0909

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Structural basis for ligand recognition of the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural basis for ligand recognition of the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Structural basis for ligand recognition of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis for ligand recognition of the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Structural basis for ligand recognition of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Structural basis for ligand recognition of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Structural basis for ligand recognition of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Structural basis for ligand recognition of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Structural basis for ligand recognition of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur neuropeptide Y › Structural basis for ligand recognition of the...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Structural basis for ligand recognition of the...