Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 02 2021
Historique:
received: 07 10 2020
accepted: 21 01 2021
entrez: 3 2 2021
pubmed: 4 2 2021
medline: 16 11 2021
Statut: epublish

Résumé

The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images. We evaluated 26 eyes of 21 patients with serous PED. RPE-melanin OCT images were calculated from the multi-contrast OCT dataset and compared with near-infrared autofluorescence images. An active RPE lesion was defined as an area of thickened RPE-melanin (≥ 70 μm; RPE

Identifiants

pubmed: 33531591
doi: 10.1038/s41598-021-82563-z
pii: 10.1038/s41598-021-82563-z
pmc: PMC7854605
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2764

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Auteurs

Masahiro Miura (M)

Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Ami, Inashiki, Ibaraki, 300395, Japan. m-miura@tokyo-med.ac.jp.

Shuichi Makita (S)

Computational Optics Group, University of Tsukuba, Tsukuba, Japan.

Yoshiaki Yasuno (Y)

Computational Optics Group, University of Tsukuba, Tsukuba, Japan.

Takuya Iwasaki (T)

Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, 3-20-1 Chuo, Ami, Inashiki, Ibaraki, 300395, Japan.

Shinnosuke Azuma (S)

Topcon Corporation, Tokyo, Japan.

Toshihiro Mino (T)

Topcon Corporation, Tokyo, Japan.

Tatsuo Yamaguchi (T)

Topcon Corporation, Tokyo, Japan.

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Classifications MeSH