Comparison the Oral Premedication of Midazolam, Dexmedetomidine, and Melatonin for Children's Sedation and Ease of Separation from Parents before Anesthesia.
Dexmedetomidine
melatonin
midazolam
premedication
sedation
Journal
Journal of pediatric neurosciences
ISSN: 1817-1745
Titre abrégé: J Pediatr Neurosci
Pays: India
ID NLM: 101273794
Informations de publication
Date de publication:
Historique:
received:
20
07
2019
revised:
01
11
2019
accepted:
04
11
2019
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
ppublish
Résumé
Children's fear of surgery and preoperative separation from parents can contribute to anxiety and distress in children undergoing surgery. The study addressed the comparable efficacy of oral premedication of midazolam, dexmedetomidine, and melatonin to alleviate preoperative anxiety and easing the children's separation from parents. A double-blinded trial enrolled three equal-sized groups of children ( A significant difference was observed in the mean scores of sedation before premedication and after separation from parents, as well as in the degree of the separation when comparing between the midazolam and melatonin groups and the dexmedetomidine and melatonin groups ( Dexmedetomidine is more effective in acceptance of anesthesia induction. Furthermore, the midazolam and dexmedetomidine groups indicated better ease of separation and sedation scores than melatonin.
Sections du résumé
BACKGROUND
BACKGROUND
Children's fear of surgery and preoperative separation from parents can contribute to anxiety and distress in children undergoing surgery. The study addressed the comparable efficacy of oral premedication of midazolam, dexmedetomidine, and melatonin to alleviate preoperative anxiety and easing the children's separation from parents.
MATERIALS AND METHODS
METHODS
A double-blinded trial enrolled three equal-sized groups of children (
RESULTS
RESULTS
A significant difference was observed in the mean scores of sedation before premedication and after separation from parents, as well as in the degree of the separation when comparing between the midazolam and melatonin groups and the dexmedetomidine and melatonin groups (
CONCLUSION
CONCLUSIONS
Dexmedetomidine is more effective in acceptance of anesthesia induction. Furthermore, the midazolam and dexmedetomidine groups indicated better ease of separation and sedation scores than melatonin.
Identifiants
pubmed: 33531937
doi: 10.4103/jpn.JPN_95_19
pii: JPN-15-231
pmc: PMC7847116
doi:
Types de publication
Journal Article
Langues
eng
Pagination
231-237Informations de copyright
Copyright: © 2020 Journal of Pediatric Neurosciences.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Paediatr Anaesth. 2014 Aug;24(8):863-74
pubmed: 24666837
Saudi J Anaesth. 2011 Oct;5(4):387-91
pubmed: 22144926
Eur J Anaesthesiol. 2005 Mar;22(3):189-96
pubmed: 15852991
Anesthesiology. 2010 Oct;113(4):968-76
pubmed: 20823763
Cochrane Database Syst Rev. 2012 Mar 14;(3):CD003877
pubmed: 22419289
Anesth Analg. 2004 May;98(5):1260-6, table of contents
pubmed: 15105197
Anesth Analg. 2008 Jun;106(6):1715-21
pubmed: 18499600
J Anaesthesiol Clin Pharmacol. 2016 Jul-Sep;32(3):353-8
pubmed: 27625485
Saudi J Anaesth. 2016 Oct-Dec;10(4):390-394
pubmed: 27833480
Anaesthesia. 2014 Oct;69(10):1163-71
pubmed: 24835540
Anesth Pain Med. 2018 Apr 16;8(2):e64236
pubmed: 30009151
Anesthesiology. 2009 Jul;111(1):44-9
pubmed: 19546692
Paediatr Anaesth. 2014 Feb;24(2):181-9
pubmed: 24237879
J Dent (Tehran). 2018 Sep;15(5):317-324
pubmed: 30833978
Int J Mol Sci. 2015 Jan 06;16(1):1209-20
pubmed: 25569095
Clinics (Sao Paulo). 2014 Nov;69(11):777-86
pubmed: 25518037
Paediatr Anaesth. 2015 May;25(5):468-76
pubmed: 25559766
AANA J. 2011 Jun;79(3):219-24
pubmed: 21751690