Melatonin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-related Diseases.
cartilage
cartilage homeostasis
cartilage-related genes
human mesenchymal stromal cells
inflammation
melatonin
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
07
02
2020
accepted:
19
05
2020
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Cartilage is a relatively simple connective tissue that plays a variety of roles in the human body, including joint support and protection, load bearing of the intervertebral discs, joint lubrication, formation of the external structure of the ears and nose and support of the trachea. The maintenance of cartilage homeostasis is therefore crucial. Cartilage-related diseases are difficult to diagnose and treat because their molecular and pathological mechanisms are not fully understood. Melatonin, which has a wide range of physiological effects, is an endocrine hormone mainly secreted by the pineal gland. Its biological effects include its antioxidant, antiaging, analgesic, and hypnotic effects and its ability to stabilize the circadian rhythm. In recent years, research on cartilage homeostasis and melatonin has been increasing, and melatonin has gradually been used in the treatment of cartilage-related diseases. Therefore, this article will briefly review the role of melatonin in cartilage homeostasis, including its anti-inflammatory effects and effects in protecting cartilage from damage by other factors and promoting chondrocyte growth and the expression of cartilage-related genes. Based on the above, the current status and future developmental direction of melatonin in the treatment of cartilage-related diseases are also discussed, demonstrating the broad prospects of melatonin in maintaining cartilage homeostasis and treating cartilage injury-related diseases.
Identifiants
pubmed: 33532142
doi: 10.14336/AD.2020.0519
pii: ad-12-1-297
pmc: PMC7801270
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
297-307Informations de copyright
copyright: © 2021 Xie et al.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare that they have no conflicts of interest pertaining to this study.
Références
J Pineal Res. 2014 Aug;57(1):53-66
pubmed: 24816289
Oncotarget. 2017 Jun 3;8(34):55967-55983
pubmed: 28915567
Tissue Eng Part A. 2012 Jan;18(1-2):45-54
pubmed: 21770865
Expert Opin Ther Targets. 2016;20(3):303-17
pubmed: 26465080
Molecules. 2018 Feb 24;23(2):
pubmed: 29495303
Autoimmun Rev. 2008 Jan;7(3):223-8
pubmed: 18190882
Pharmacol Rep. 2009 May-Jun;61(3):383-410
pubmed: 19605939
Ageing Res Rev. 2018 Aug;45:33-52
pubmed: 29630951
J Mech Behav Biomed Mater. 2017 Oct;74:1-10
pubmed: 28521277
Int Immunopharmacol. 2002 Sep;2(10):1443-9
pubmed: 12400874
Cell Tissue Res. 2017 Oct;370(1):53-70
pubmed: 28413859
Arthritis Res. 2001;3(6):342-7
pubmed: 11714388
Biochem Pharmacol. 2010 Dec 15;80(12):1844-52
pubmed: 20696138
Int J Mol Sci. 2013 May 24;14(6):10979-97
pubmed: 23708099
Physiol Rev. 2016 Apr;96(2):409-47
pubmed: 26842265
Rheumatol Int. 2013 Jul;33(7):1829-35
pubmed: 23328930
Endocrinology. 2016 Aug;157(8):3096-107
pubmed: 27253997
Br J Pharmacol. 2018 Aug;175(16):3230-3238
pubmed: 28585236
PLoS One. 2019 Aug 15;14(8):e0221083
pubmed: 31415653
Clin Exp Rheumatol. 2016 Sep-Oct;34(5):929-934
pubmed: 27606839
J Cell Mol Med. 2019 Jan;23(1):177-193
pubmed: 30353656
Indian J Biochem Biophys. 2007 Feb;44(1):14-8
pubmed: 17385335
Nat Rev Rheumatol. 2015 Apr;11(4):206-12
pubmed: 25536487
Bioessays. 2016 Dec;38(12):1193-1194
pubmed: 27739090
Free Radic Biol Med. 2014 Mar;68:234-46
pubmed: 24374373
Heliyon. 2019 Feb 01;5(1):e01190
pubmed: 30775579
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Feb;104(2):221-4
pubmed: 8098676
Orthopade. 2017 Nov;46(11):893
pubmed: 28956062
Biomed Res Int. 2017;2017:8686207
pubmed: 29333456
Tissue Cell. 1996 Aug;28(4):455-68
pubmed: 8760859
Adv Orthop. 2012;2012:834208
pubmed: 22900195
J Pineal Res. 2013 Apr;54(3):245-57
pubmed: 22998574
Farmaco Sci. 1958;13(8):604-5
pubmed: 13574220
Molecules. 2015 Oct 16;20(10):18886-906
pubmed: 26501252
J Mater Sci Mater Med. 2017 Aug;28(8):115
pubmed: 28647792
Arthritis Rheum. 2005 Nov;52(11):3507-14
pubmed: 16258919
Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7
pubmed: 30174297
Oncotarget. 2017 Jul 16;8(57):97633-97647
pubmed: 29228639
J Pineal Res. 1986;3(4):379-88
pubmed: 3783419
J Circadian Rhythms. 2015 Mar 10;13:1
pubmed: 27103927
Cell Mol Life Sci. 2014 Aug;71(16):2997-3025
pubmed: 24554058
J Endocrinol. 2019 Mar 1;:
pubmed: 30889551
J Med Chem. 2014 Apr 24;57(8):3161-85
pubmed: 24228714
FASEB J. 2014 Jul;28(7):2775-89
pubmed: 24668754
J Pineal Res. 2012 Oct;53(3):225-37
pubmed: 22507555
Arch Endocrinol Metab. 2018 Aug;62(4):472-479
pubmed: 30304113
Int J Biol Macromol. 2019 Oct 15;139:1168-1181
pubmed: 31419553
Hua Xi Kou Qiang Yi Xue Za Zhi. 2019 Apr 1;37(2):220-223
pubmed: 31168991
J Biol Chem. 1995 Mar 31;270(13):7037-40
pubmed: 7706239
Matrix Biol. 2014 Sep;38:3-11
pubmed: 25083813
Transplant Proc. 2014 May;46(4):1217-21
pubmed: 24815164
Steroids. 2017 Oct;126:24-29
pubmed: 28803211
J Pineal Res. 2019 Nov;67(4):e12606
pubmed: 31442321
J Biomed Mater Res A. 2018 Jul;106(7):1932-1940
pubmed: 29569835
Arthritis Res Ther. 2017 Feb 2;19(1):18
pubmed: 28148295
J Pineal Res. 2018 Nov;65(4):e12524
pubmed: 30230594
Osteoarthritis Cartilage. 2017 Feb;25(2):209-215
pubmed: 28100423
Endocrine. 2005 Jul;27(2):101-10
pubmed: 16217123
Clin Sports Med. 2017 Jul;36(3):413-425
pubmed: 28577703
Neurochirurgie. 2015 Apr-Jun;61(2-3):77-84
pubmed: 25908646
J Pineal Res. 2020 Apr;68(3):e12636
pubmed: 32043640
Eur Cell Mater. 2018 Sep 11;36:96-109
pubmed: 30204229
J Knee Surg. 2018 Mar;31(3):231-238
pubmed: 29396963
Connect Tissue Res. 2016 Jul;57(4):245-61
pubmed: 27285430
J Cell Biochem. 2013 Oct;114(10):2346-55
pubmed: 23824714
Exp Dermatol. 2017 Jul;26(7):563-568
pubmed: 27619234
J Pineal Res. 2018 Aug;65(1):e12483
pubmed: 29498095
Acta Orthop. 2016 Dec;87(sup363):26-38
pubmed: 27910738
J Mater Chem B. 2019 Nov 14;7(42):6564-6575
pubmed: 31588948
Arthritis Res Ther. 2016 Dec 13;18(1):296
pubmed: 27964744
Int J Med Sci. 2013 Aug 22;10(10):1392-8
pubmed: 23983601
Arthritis Rheum. 2013 Apr;65(4):981-92
pubmed: 23400684
J Pineal Res. 2014 Jan;56(1):62-70
pubmed: 24117903
Sports Med Arthrosc Rev. 2018 Mar;26(1):31-39
pubmed: 29300225
Ann Rheum Dis. 2016 Feb;75(2):390-5
pubmed: 25488799
Osteoarthritis Cartilage. 2005 Aug;13(8):643-54
pubmed: 15936958
Histochem J. 1997 Sep;29(9):645-54
pubmed: 9413737
J Neuroimmunol. 1992 Jul;39(1-2):23-30
pubmed: 1619037
Br J Pharmacol. 2018 Aug;175(16):3239-3250
pubmed: 29105727
J Pineal Res. 2013 Aug;55(1):14-25
pubmed: 23488678
Osteoarthritis Cartilage. 2006 Aug;14(8):738-48
pubmed: 16563811
Osteoarthritis Cartilage. 2015 Mar;23(3):351-62
pubmed: 25450846
J Clin Invest. 2001 Jan;107(1):35-44
pubmed: 11134178
J Pineal Res. 2009 Mar;46(2):181-7
pubmed: 19054299
Exp Hematol. 2019 Oct;78:1-10
pubmed: 31494174
Br J Pharmacol. 2008 Jul;154(6):1182-95
pubmed: 18493248
Tissue Eng Part B Rev. 2015 Jun;21(3):267-77
pubmed: 25366980
PLoS One. 2011;6(10):e26393
pubmed: 22039478
Methods. 2016 Apr 15;99:69-80
pubmed: 26384579
Trends Pharmacol Sci. 1995 Feb;16(2):50-6
pubmed: 7762083
J Pineal Res. 2019 Apr;66(3):e12560
pubmed: 30648758
Curr Opin Rheumatol. 2017 Jan;29(1):79-85
pubmed: 27755180
Neurochem Int. 1994 Feb;24(2):101-46
pubmed: 8161940
J Pineal Res. 2016 Nov;61(4):411-425
pubmed: 27555371
Stem Cell Res Ther. 2018 Jun 14;9(1):162
pubmed: 29898779
Prog Neurobiol. 2011 Mar;93(3):350-84
pubmed: 21193011
Biogerontology. 2015 Apr;16(2):209-19
pubmed: 25078075