Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective.
Vascular dementia
central cholinergic system
neuroinflammation
neuronal apoptosis
oxidative stress
pharmacological treatment
synaptic plasticity
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
10
03
2020
accepted:
27
04
2020
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction attributable to cerebrovascular factors. At present, it is the second most frequently occurring type of dementia in older adults (after Alzheimer's disease). The underlying etiology of VaD has not been completely elucidated, which limits its management. Currently, there are no approved standard treatments for VaD. The drugs used in VaD are only suitable for symptomatic treatment and cannot prevent or reduce the occurrence and progression of VaD. This review summarizes the current status of pharmacological treatment for VaD, from the perspective of the molecular mechanisms specified in various pathogenic hypotheses, including oxidative stress, the central cholinergic system, neuroinflammation, neuronal apoptosis, and synaptic plasticity. As VaD is a chronic cerebrovascular disease with multifactorial etiology, combined therapy, targeting multiple pathophysiological factors, may be the future trend in VaD.
Identifiants
pubmed: 33532143
doi: 10.14336/AD.2020.0427
pii: ad-12-1-308
pmc: PMC7801279
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
308-326Informations de copyright
copyright: © 2021 Kuang et al.
Déclaration de conflit d'intérêts
Declaration of interest The authors declare no conflict of interest.
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