Profile of Patients With Tuberculous Pleural Effusion in Qatar: A Retrospective Study.
acid-fast bacillus
bmi
lights criteria
pleural effusion
tuberculosis
tuberculous pleural effusion
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Introduction Tuberculosis (TB) remains one of the top 10 causes of death globally. Around 1.7 billion people are infected with mycobacterium TB worldwide, and almost 90% of cases each year are found in 30 high TB burden countries. Due to the influx of a large expatriate population mainly from the high TB burden countries, there is an increased number of pulmonary TB as well as tuberculous pleural effusion cases reported in Qatar. Objectives The demographic, clinical, laboratory, and histopathological parameters of patients with tuberculous pleural effusion were assessed. Methods A single-center study was conducted at Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. Adults diagnosed to have tuberculous pleural effusion were included, and those with clinical suspicion of tuberculous pleural effusion with positive sputum acid-fast bacillus (AFB) but negative AFB in pleural samples were excluded. Results A total of 106 patients were reviewed, of whom 100 were included for the final analysis, with 86% being men. Majority were from the Asian subcontinent, and the mean age was 33.8 years (SD ± 10.3). Main symptoms in decreasing order were cough (77%), fever (56%), and chest pain (54%). Of the patients, 72% had normal BMI, and rest were above the normal range. Anemia and hypoalbuminemia were found in 36.7% and 89.8% of the patients, respectively. Positive AFB culture was observed in pleural biopsy (79%), pleural fluid (13%), and sputum (16%). Positive AFB by polymerase chain reaction (PCR) was observed in pleural biopsy (57%), pleural fluid (3%), and sputum (2.2%), whereas AFB smear was positive in 2% of pleural biopsy samples. Caseating granuloma was seen in 80% of patients. All the three Light's criteria were met by 30% of the patients whereas 52% had two criteria fulfilled. No association between the number of Light's criteria and AFB yield was observed. Conclusions TPE was more common in healthy young adults. The AFB yield on pleural biopsy, PCR, and culture was significantly higher than that on all other samples. The number of positive Light's criteria did not have any association with positive AFB yield.
Identifiants
pubmed: 33532154
doi: 10.7759/cureus.12391
pmc: PMC7845742
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12391Informations de copyright
Copyright © 2020, Zahid et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur Respir J. 2003 Oct;22(4):589-91
pubmed: 14582908
Lung India. 2011 Jan;28(1):21-4
pubmed: 21654981
Respirology. 2018 Jul;23(7):714-717
pubmed: 29486527
Arch Intern Med. 2007 Jun 25;167(12):1297-304
pubmed: 17592104
ERJ Open Res. 2018 Jan 05;4(1):
pubmed: 29318136
Am Rev Tuberc. 1955 Apr;71(4):473-502
pubmed: 14361964
Respirology. 2010 Apr;15(3):451-8
pubmed: 20345583
Int J Infect Dis. 2019 Jan;78:34-38
pubmed: 30449728
Biomed Res Int. 2016;2016:7508763
pubmed: 27419136
Thorax. 2013 Mar;68(3):290-1
pubmed: 22863812
Am J Respir Crit Care Med. 2003 Mar 1;167(5):723-5
pubmed: 12598215
Int J Lab Hematol. 2013 Jun;35(3):254-61
pubmed: 23590652
Chest. 1973 Jan;63(1):88-92
pubmed: 4630686
Clin Chem Lab Med. 2007;45(8):1009-13
pubmed: 17867990
Arch Intern Med. 1998 Oct 12;158(18):2017-21
pubmed: 9778201
East Mediterr Health J. 2011 Jul;17(7):611-8
pubmed: 21972486
J Res Med Sci. 2015 Jan;20(1):26-31
pubmed: 25767518
Trop Med Int Health. 1998 Jan;3(1):14-20
pubmed: 9484963
Eur J Respir Dis. 1986 Nov;69(5):355-62
pubmed: 3792471
East Afr Med J. 1994 Apr;71(4):246-9
pubmed: 8062772
Chest. 2007 Apr;131(4):1125-32
pubmed: 17426219
Trans R Soc Trop Med Hyg. 2002 May-Jun;96(3):291-4
pubmed: 12174782
Clin Infect Dis. 2017 Jan 15;64(2):111-115
pubmed: 28052967
Int J Tuberc Lung Dis. 2001 Aug;5(8):746-53
pubmed: 11495266
Chest. 2007 Mar;131(3):880-889
pubmed: 17356108
Int J Tuberc Lung Dis. 2004 Feb;8(2):211-7
pubmed: 15139450
Eur J Radiol. 2004 Aug;51(2):139-49
pubmed: 15246519