Aspiration and severe exacerbations in COPD: a prospective study.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
12
10
2020
accepted:
19
10
2020
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
Swallow may be compromised in COPD leading to aspiration and adverse respiratory consequences. However, prevalence and consequences of detectable aspiration in stable COPD are not known. We tested the hypothesis that a significant number of patients with stable COPD will have detectable aspiration during swallow (prandial aspiration) and that they would experience more frequent severe acute exacerbations of COPD (AECOPD) over the subsequent 12 months. Patients (n=151) with verified and stable COPD of all severities were recruited at a tertiary care hospital. Videofluoroscopy was conducted to evaluate aspiration using Rosenbek's scale for penetration-aspiration during 100-mL cup drinking. AECOPD was documented as moderate (antibiotics and/or corticosteroid treatment) or severe (emergency department admission or hospitalisation) over the ensuing 12 months. Aspiration was observed in 30 out of 151 patients (19.9%, 18 males, 12 females; mean age 72.4 years). Patients with aspiration had more overall AECOPD events (3.03 Prandial aspiration is detectable in a subset of patients with COPD and was predictive of subsequent severe AECOPD. Studies to examine if the association is causal are essential to direct strategies aimed at prevention of aspiration and AECOPD.
Identifiants
pubmed: 33532466
doi: 10.1183/23120541.00735-2020
pii: 00735-2020
pmc: PMC7836559
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©ERS 2021.
Déclaration de conflit d'intérêts
Conflict of interest: L Cvejic has nothing to disclose. Conflict of interest: N. Guiney has nothing to disclose. Conflict of interest: T. Nicholson has nothing to disclose. Conflict of interest: K.K. Lau has nothing to disclose. Conflict of interest: P. Finlay has nothing to disclose. Conflict of interest: K. Hamza has nothing to disclose. Conflict of interest: C. Osadnik reports they were the recipient of a Lung Foundation Australia COPD Research Fellowship (2016–2018; AUD$160 000) and is the recipient of a Rebecca L. Cooper Medical Research Foundation Project Grant (2020–2021; AUD$100 000). Conflict of interest: P. Leong is supported by the National Health and Medical Research Council Postgraduate Scholarship and the Royal Australasian College of Physicians, outside of this work. Views expressed do not necessarily reflect those of the funding bodies. Conflict of interest: M. MacDonald has nothing to disclose. Conflict of interest: P.T. King has nothing to disclose. Conflict of interest: P.G. Bardin has nothing to disclose.
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