A novel bilayered expanded polytetrafluoroethylene glaucoma implant creates a permeable thin capsule independent of aqueous humor exposure.
bleb
capsule
expanded polytetrafluoroethylene (ePTFE)
fibrosis
glaucoma
glaucoma drainage implant (GDI)
intraocular pressure (IOP)
Journal
Bioengineering & translational medicine
ISSN: 2380-6761
Titre abrégé: Bioeng Transl Med
Pays: United States
ID NLM: 101689146
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
15
06
2020
revised:
31
07
2020
accepted:
02
08
2020
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
4
2
2021
Statut:
epublish
Résumé
The purpose of these studies was to evaluate clinical, functional, and histopathological features of glaucoma drainage implants (GDIs) fabricated from novel, custom-tailored expanded polytetrafluoroethylene (ePTFE). Implants of matching footprints were fabricated from silicone (Control) and novel, bilayered ePTFE. ePTFE implants included: (a) one that inflated with aqueous humor (AH) (High), (b) one that inflated with a lower profile (Low), (c) an uninflated implant not connected to the anterior chamber (Flat), and (d) one filled with material that did not allow AH flow (Filled). All implants were placed in adult New Zealand White rabbits and followed over 1-3 months with clinical exams and intraocular pressure. The permeability of tissue capsules surrounding GDIs was assessed using constant-flow perfusion with fluoresceinated saline at physiologic flow rates. After sacrifice, quantitative histopathological measures of capsule thickness were compared among devices, along with qualitative assessment of cellular infiltration and inflammation. Capsular thickness was significantly reduced in blebs over ePTFE (61.4 ± 53 μm) versus silicone implants (193.6 ± 53 μm,
Identifiants
pubmed: 33532583
doi: 10.1002/btm2.10179
pii: BTM210179
pmc: PMC7823119
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10179Informations de copyright
© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
Déclaration de conflit d'intérêts
6This work was sponsored by a grant from W.L. Gore & Associates, Inc., Newark, Delaware. P. R., J. T., and M. T. are employees of the research sponsor, W.L. Gore & Associates, Inc. and received no additional compensation, funding, or support in connection with the study. All other authors are paid consultants to W.L. Gore & Associates, Inc.
Références
JAMA Ophthalmol. 2015 May;133(5):549-54
pubmed: 25719729
Invest Ophthalmol Vis Sci. 1997 Jul;38(8):1639-46
pubmed: 9224294
J Glaucoma. 1996 Oct;5(5):334-9
pubmed: 8897233
Invest Ophthalmol Vis Sci. 2013 Jun 06;54(6):3957-64
pubmed: 23674756
J Glaucoma. 2003 Jun;12(3):266-71
pubmed: 12782847
J Glaucoma. 2001 Apr;10(2):115-20
pubmed: 11316093
Curr Eye Res. 2011 Feb;36(2):112-7
pubmed: 21281065
Invest Ophthalmol Vis Sci. 1993 Oct;34(11):3076-83
pubmed: 8104910
J Glaucoma. 1994 Summer;3(2):140-51
pubmed: 19920567
Curr Eye Res. 2009 Jul;34(7):562-7
pubmed: 19899969
Cochrane Database Syst Rev. 2019 Apr 19;4:CD011875
pubmed: 30999387
Invest Ophthalmol Vis Sci. 2010 Feb;51(2):903-6
pubmed: 19737888
J Biomed Mater Res. 1999;48(5):591-5
pubmed: 10490671
Trans Ophthalmol Soc N Z. 1979;31:17-26
pubmed: 293078
Arch Ophthalmol. 1998 Mar;116(3):286-91
pubmed: 9514480
Am J Ophthalmol. 2016 Mar;163:75-82.e3
pubmed: 26596400
Biosci Rep. 2019 May 2;39(5):
pubmed: 30967499
Arch Ophthalmol. 2011 Aug;129(8):993-7
pubmed: 21825182
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):163-169
pubmed: 27766415
Ophthalmology. 2015 Feb;122(2):308-16
pubmed: 25439606
J Glaucoma. 1995 Aug;4(4):274-80
pubmed: 19920686
Am J Ophthalmol. 2012 May;153(5):804-814.e1
pubmed: 22244522
Am J Ophthalmol. 2012 May;153(5):789-803.e2
pubmed: 22245458
Biomed Sci Instrum. 2001;37:257-62
pubmed: 11347399
Ophthalmologica. 2007;221(4):238-43
pubmed: 17579289
Arch Ophthalmol. 1983 May;101(5):795-8
pubmed: 6847472
J Glaucoma. 2002 Oct;11(5):406-10
pubmed: 12362079
Ocul Immunol Inflamm. 2018;26(8):1177-1188
pubmed: 28622063
Surv Ophthalmol. 2003 May-Jun;48(3):314-46
pubmed: 12745005
J Curr Glaucoma Pract. 2016 Sep-Dec;10(3):91-96
pubmed: 27857488
Br J Ophthalmol. 2000 Dec;84(12):1349-53
pubmed: 11090471
Curr Opin Ophthalmol. 2018 Mar;29(2):162-170
pubmed: 29319544
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6441-7
pubmed: 20592224
Exp Eye Res. 1994 Dec;59(6):723-7
pubmed: 7698265
Korean J Ophthalmol. 2003 Dec;17(2):106-13
pubmed: 14717488
Biochim Biophys Acta. 2015 Nov;1853(11 Pt B):3153-64
pubmed: 25930943
Acta Ophthalmol. 2008 May;86(3):314-21
pubmed: 17995980
J Biomed Mater Res. 1999 Nov;47(2):260-9
pubmed: 10449638
Br J Ophthalmol. 2003 Jan;87(1):63-70
pubmed: 12488265
Invest Ophthalmol Vis Sci. 2012 Oct 05;53(11):6914-9
pubmed: 22956615