Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity.
Bioinformatics
Genetics
Phylogenetics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Feb 2021
19 Feb 2021
Historique:
received:
08
09
2020
revised:
09
11
2020
accepted:
22
01
2021
pubmed:
4
2
2021
medline:
4
2
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
To dissect the mechanisms underlying the inflation of variants in the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) genome, we present a large-scale analysis of intra-host genomic diversity, which reveals that most samples exhibit heterogeneous genomic architectures, due to the interplay between host-related mutational processes and transmission dynamics. The decomposition of minor variants profiles unveils three non-overlapping mutational signatures related to nucleotide substitutions and likely ruled by APOlipoprotein B Editing Complex (APOBEC), Reactive Oxygen Species (ROS), and Adenosine Deaminase Acting on RNA (ADAR), highlighting heterogeneous host responses to SARS-CoV-2 infections. A corrected-for-signatures
Identifiants
pubmed: 33532709
doi: 10.1016/j.isci.2021.102116
pii: S2589-0042(21)00084-5
pmc: PMC7842190
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102116Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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