Magnetic resonance image-guided focused ultrasound robotic system for transrectal prostate cancer therapy.
MRI
MRgFUS
focused ultrasound
prostate
robotic device
Journal
The international journal of medical robotics + computer assisted surgery : MRCAS
ISSN: 1478-596X
Titre abrégé: Int J Med Robot
Pays: England
ID NLM: 101250764
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
02
01
2021
received:
08
10
2020
accepted:
17
01
2021
pubmed:
4
2
2021
medline:
21
7
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
A magnetic resonance image (MRI) guided robotic device for focussed ultrasound therapy of prostate cancer (PC) was developed. The device offers movement in 5 degrees of freedom (DOF) and uses a single-element transducer that operates at 3.2 MHz, has a diameter of 25 mm and focuses at 45 mm. The MRI compatibility of the system was evaluated in a 1.5 T scanner. The ability of the transducer to create lesions was evaluated in laboratory and MRI settings, on ex vivo pork tissue and in vivo rabbit thigh tissue. Cavitational and thermal lesions were created on the excised pork tissue. In vivo experiments proved the efficacy of the system in ablating muscle tissue without damaging intervening areas. The MRI compatible robotic system can be placed on the table of any commercial MRI scanner up to 7 T. The device has the ability of future use for transrectal focal therapy of PC with the patient in supine position.
Sections du résumé
BACKGROUND
BACKGROUND
A magnetic resonance image (MRI) guided robotic device for focussed ultrasound therapy of prostate cancer (PC) was developed. The device offers movement in 5 degrees of freedom (DOF) and uses a single-element transducer that operates at 3.2 MHz, has a diameter of 25 mm and focuses at 45 mm.
METHODS
METHODS
The MRI compatibility of the system was evaluated in a 1.5 T scanner. The ability of the transducer to create lesions was evaluated in laboratory and MRI settings, on ex vivo pork tissue and in vivo rabbit thigh tissue.
RESULTS
RESULTS
Cavitational and thermal lesions were created on the excised pork tissue. In vivo experiments proved the efficacy of the system in ablating muscle tissue without damaging intervening areas.
CONCLUSIONS
CONCLUSIONS
The MRI compatible robotic system can be placed on the table of any commercial MRI scanner up to 7 T. The device has the ability of future use for transrectal focal therapy of PC with the patient in supine position.
Identifiants
pubmed: 33533112
doi: 10.1002/rcs.2237
pmc: PMC8244034
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2237Subventions
Organisme : Research & Innovation Foundation of Cyprus
ID : ENTERPRISES/0918/0012
Informations de copyright
© 2021 Cyprus University of Technology. The International Journal of Medical Robotics and Computer Assisted Surgery published by John Wiley & Sons Ltd.
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