Graphene Sheets with Defined Dual Functionalities for the Strong SARS-CoV-2 Interactions.
SARS-CoV-2 inhibitor
graphene
graphene-based polyglycerol sulfates
virucidality
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
05
01
2021
received:
11
11
2020
pubmed:
4
2
2021
medline:
1
4
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Search of new strategies for the inhibition of respiratory viruses is one of the urgent health challenges worldwide, as most of the current therapeutic agents and treatments are inefficient. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic and has taken lives of approximately two million people to date. Even though various vaccines are currently under development, virus, and especially its spike glycoprotein can mutate, which highlights a need for a broad-spectrum inhibitor. In this work, inhibition of SARS-CoV-2 by graphene platforms with precise dual sulfate/alkyl functionalities is investigated. A series of graphene derivatives with different lengths of aliphatic chains is synthesized and is investigated for their ability to inhibit SARS-CoV-2 and feline coronavirus. Graphene derivatives with long alkyl chains (>C9) inhibit coronavirus replication by virtue of disrupting viral envelope. The ability of these graphene platforms to rupture viruses is visualized by atomic force microscopy and cryogenic electron microscopy. A large concentration window (10 to 100-fold) where graphene platforms display strongly antiviral activity against native SARS-CoV-2 without significant toxicity against human cells is found. In this concentration range, the synthesized graphene platforms inhibit the infection of enveloped viruses efficiently, opening new therapeutic and metaphylactic avenues against SARS-CoV-2.
Identifiants
pubmed: 33533178
doi: 10.1002/smll.202007091
pmc: PMC7995151
doi:
Substances chimiques
Antiviral Agents
0
Graphite
7782-42-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2007091Subventions
Organisme : DFG
Organisme : Berlin University Alliance
Organisme : China Scholarship Council
Informations de copyright
© 2021 The Authors. Small published by Wiley-VCH GmbH.
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