A Network of Psychopathological, Cognitive, and Motor Symptoms in Schizophrenia Spectrum Disorders.
cognition
extrapyramidal symptoms
negative symptoms
network analysis
positive symptoms
psychosis
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
pubmed:
4
2
2021
medline:
17
12
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Schizophrenia spectrum disorders (SSDs) are complex syndromes involving psychopathological, cognitive, and also motor symptoms as core features. A better understanding of how these symptoms mutually impact each other could translate into diagnostic, prognostic, and, eventually, treatment advancements. The present study aimed to: (1) estimate a network model of psychopathological, cognitive, and motor symptoms in SSD; (2) detect communities and explore the connectivity and relative importance of variables within the network; and (3) explore differences in subsample networks according to remission status. A sample of 1007 patients from a multisite cohort study was included in the analysis. We estimated a network of 43 nodes, including all the items from the Positive and Negative Syndrome Scale, a cognitive assessment battery and clinical ratings of extrapyramidal symptoms. Methodologies specific to network analysis were employed to address the study's aims. The estimated network for the total sample was densely interconnected and organized into 7 communities. Nodes related to insight, abstraction capacity, attention, and suspiciousness were the main bridges between network communities. The estimated network for the subgroup of patients in remission showed a sparser density and a different structure compared to the network of nonremitted patients. In conclusion, the present study conveys a detailed characterization of the interrelations between a set of core clinical elements of SSD. These results provide potential novel clues for clinical assessment and intervention.
Identifiants
pubmed: 33533401
pii: 6127082
doi: 10.1093/schbul/sbab002
pmc: PMC8266645
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
915-926Investigateurs
Therese van Amelsvoort
(TV)
Agna A Bartels-Velthuis
(AA)
Richard Bruggeman
(R)
Wiepke Cahn
(W)
Lieuwe de Haan
(L)
Rene S Kahn
(RS)
Claudia J P Simons
(CJP)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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