A novel exercise testing algorithm to diagnose mitochondrial myopathy.
V˙O2/work slope
cardiopulmonary exercise testing
mitochondrial myopathy
oxygen uptake
oxygen uptake efficiency slope
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
25
01
2021
received:
04
03
2020
accepted:
31
01
2021
pubmed:
4
2
2021
medline:
11
6
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Oxygen uptake efficiency slope (OUES) is a noninvasive cardiopulmonary exercise testing (CPET) measurement based on oxygen uptake (V˙O We performed cycle ergometer maximal exercise testing on definite and suspected mitochondrial myopathy subjects (MM-D and MM-S) and their age- and sex-matched controls. OUES was corrected for body surface area (OUES/BSA) to eliminate the effect of body size. A total of 40 participants, including 20 MM-D (n = 13; 6 males; aged 14-64 years) and 7 MM-S (5 males, aged 11-30 years) subjects and 20 controls, completed the study. MM-D subjects showed lower aerobic fitness than controls. OUES/BSA was lower in MM-D subjects, suggesting inefficient oxygen utilization. Area under the curve (AUC) and 95% confidence interval (CI) for OUES/BSA (AUC, 0.91; 95% CI, 0.80-1.00), peak V˙O We proposed and applied an approach based on the aformentioned three CPET parameters to diagnose mitochondrial myopathy reliably and found it to be clinically useful.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
715-723Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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