Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Journal
Toxicity report series
ISSN: 1521-4621
Titre abrégé: Toxic Rep Ser
Pays: United States
ID NLM: 101122696
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
entrez:
3
2
2021
pubmed:
1
8
2019
medline:
1
8
2019
Statut:
ppublish
Résumé
Widespread exposure to several per/polyfluorinated alkyl substances (PFAS) is associated with a variety of toxicities that include liver and endocrine toxicity. The National Toxicology Program (NTP) conducted 28-day toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (n = 10/dose; five doses per chemical) to compare the toxicities of seven PFAS (three sulfonic acids or salt: perfluorobutane sulfonic acid [PFBS], perfluorohexane sulfonate potassium salt [PFHxSK], and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in deionized water with 2% Tween 80. This report describes the studies for the two sulfonic acids (PFBS and PFOS) and salt (PFHxSK); a companion report (NTP Toxicity Study Report 97) describes the studies for the PFAS carboxylates. Doses were 0 to 1,000 mg/kg/day for PFBS, 0 to 10 mg/kg/day for PFHxSK males, 0 to 50 mg/kg/day for PFHxSK females, and 0 to 5 mg/kg/day for PFOS. (Abstract Abridged).
Identifiants
pubmed: 33533754
pii: NTP-TOX-96
doi: 10.22427/NTP-TOX-96
pmc: PMC8039888
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
C R Blystone
(CR)
A L Dzierlenga
(AL)
R A Herbert
(RA)
K S Janardhan
(KS)
S A Bouknight
(SA)
M A Buccellato
(MA)
M C Cora
(MC)
T A Cristy
(TA)
H C Cunny
(HC)
M J DeVito
(MJ)
J M Fostel
(JM)
D K Gerken
(DK)
S W Graves
(SW)
M R Hejtmancik
(MR)
M J Hooth
(MJ)
A P King-Herbert
(AP)
L H Kooistra
(LH)
D E Malarkey
(DE)
S A Masten
(SA)
B S McIntyre
(BS)
T A Peace
(TA)
C J Price
(CJ)
G K Roberts
(GK)
V G Robinson
(VG)
K R Shockley
(KR)
S L Smith-Roe
(SL)
B R Sparrow
(BR)
M K Vallant
(MK)
S Waidyanatha
(S)
N J Walker
(NJ)
K L Witt
(KL)
A Zmarowski
(A)
Informations de copyright
This is a work of the US government and distributed under the terms of the Public Domain.