Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control.
Journal
Memorias do Instituto Oswaldo Cruz
ISSN: 1678-8060
Titre abrégé: Mem Inst Oswaldo Cruz
Pays: Brazil
ID NLM: 7502619
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
06
2020
accepted:
16
12
2020
entrez:
3
2
2021
pubmed:
4
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector control have produced resistant populations to deltamethrin, the sole molecule available to control adult mosquitoes in this French Territory. Our surveillance aimed to provide public health authorities with data on insecticide resistance in Ae. aegypti populations and other species of interest in French Guiana. Monitoring resistance to the insecticide used for vector control and to other molecule is a key component to develop an insecticide resistance management plan. In 2009, we started to monitor resistance phenotypes to deltamethrin and target-site mechanisms in Ae. aegypti populations across the territory using the WHO impregnated paper test and allelic discrimination assay. Eight years surveillance revealed well-installed resistance and the dramatic increase of alleles on the sodium voltage-gated gene, known to confer resistance to pyrethroids (PY). In addition, we observed that populations were resistant to malathion (organophosphorous, OP) and alpha-cypermethrin (PY). Some resistance was also detected to molecules from the carbamate family. Finally, those populations somehow recovered susceptibility against fenitrothion (OP). In addition, other species distributed in urban areas revealed to be also resistant to pyrethroids. The resistance level can jeopardize the efficiency of chemical adult control in absence of other alternatives and conducts to strongly rely on larval control measures to reduce mosquito burden. Vector control strategies need to evolve to maintain or regain efficacy during epidemics.
Sections du résumé
BACKGROUND
BACKGROUND
Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector control have produced resistant populations to deltamethrin, the sole molecule available to control adult mosquitoes in this French Territory.
OBJECTIVES
OBJECTIVE
Our surveillance aimed to provide public health authorities with data on insecticide resistance in Ae. aegypti populations and other species of interest in French Guiana. Monitoring resistance to the insecticide used for vector control and to other molecule is a key component to develop an insecticide resistance management plan.
METHODS
METHODS
In 2009, we started to monitor resistance phenotypes to deltamethrin and target-site mechanisms in Ae. aegypti populations across the territory using the WHO impregnated paper test and allelic discrimination assay.
FINDINGS
RESULTS
Eight years surveillance revealed well-installed resistance and the dramatic increase of alleles on the sodium voltage-gated gene, known to confer resistance to pyrethroids (PY). In addition, we observed that populations were resistant to malathion (organophosphorous, OP) and alpha-cypermethrin (PY). Some resistance was also detected to molecules from the carbamate family. Finally, those populations somehow recovered susceptibility against fenitrothion (OP). In addition, other species distributed in urban areas revealed to be also resistant to pyrethroids.
CONCLUSION
CONCLUSIONS
The resistance level can jeopardize the efficiency of chemical adult control in absence of other alternatives and conducts to strongly rely on larval control measures to reduce mosquito burden. Vector control strategies need to evolve to maintain or regain efficacy during epidemics.
Identifiants
pubmed: 33533870
pii: S0074-02762020000100359
doi: 10.1590/0074-02760200313
pmc: PMC7849183
pii:
doi:
Substances chimiques
Insecticides
0
Pyrethrins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e200313Références
PLoS Negl Trop Dis. 2017 Apr 5;11(4):e0005526
pubmed: 28379969
PLoS Negl Trop Dis. 2019 Jun 3;13(6):e0007432
pubmed: 31158225
PLoS Negl Trop Dis. 2017 Jul 20;11(7):e0005625
pubmed: 28727779
Genome Res. 2015 Sep;25(9):1347-59
pubmed: 26206155
Mem Inst Oswaldo Cruz. 2018 Mar 12;113(5):e170398
pubmed: 29538490
Pest Manag Sci. 2020 Jun;76(6):2144-2157
pubmed: 31957156
Trop Med Int Health. 2011 Apr;16(4):501-9
pubmed: 21342372
J Med Entomol. 2002 Nov;39(6):882-8
pubmed: 12495187
Pestic Biochem Physiol. 2019 Oct;160:119-126
pubmed: 31519246
PLoS Negl Trop Dis. 2015 Dec 11;9(12):e0004263
pubmed: 26658798
Acta Trop. 2019 Mar;191:146-154
pubmed: 30552882
Med Vet Entomol. 2003 Mar;17(1):87-94
pubmed: 12680930
Insect Mol Biol. 2007 Dec;16(6):785-98
pubmed: 18093007
PLoS Negl Trop Dis. 2015 Nov 20;9(11):e0004226
pubmed: 26588076
Parasit Vectors. 2019 Jan 9;12(1):20
pubmed: 30626410
PLoS Negl Trop Dis. 2018 Feb 12;12(2):e0006227
pubmed: 29432488
Mem Inst Oswaldo Cruz. 2011 May;106(3):346-52
pubmed: 21655824
PLoS One. 2013 Oct 18;8(10):e77857
pubmed: 24204999
Evol Appl. 2019 Sep 27;13(2):303-317
pubmed: 31993078
Am J Trop Med Hyg. 2010 Aug;83(2):277-84
pubmed: 20682868
Am J Trop Med Hyg. 1987 Jul;37(1):37-41
pubmed: 2886070
PLoS One. 2019 Jun 24;14(6):e0218079
pubmed: 31233517
Med Vet Entomol. 2002 Dec;16(4):456-60
pubmed: 12510901
PLoS Negl Trop Dis. 2018 Aug 20;12(8):e0006734
pubmed: 30125295
PLoS One. 2013 Apr 08;8(4):e60878
pubmed: 23593337
Mem Inst Oswaldo Cruz. 2019 Sep 23;114:e190120
pubmed: 31553370
PLoS Negl Trop Dis. 2019 Oct 10;13(10):e0007615
pubmed: 31600206
Sci Rep. 2018 Aug 22;8(1):12535
pubmed: 30135460