Age differences in functional network reconfiguration with working memory training.
Sternberg task
cingulo-opercular network
global efficiency
graph theory
intrinsic activity
participation coefficient
task-related connectivity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 04 2021
15 04 2021
Historique:
revised:
21
12
2020
received:
19
05
2020
accepted:
22
12
2020
pubmed:
4
2
2021
medline:
6
1
2022
entrez:
3
2
2021
Statut:
ppublish
Résumé
Demanding cognitive functions like working memory (WM) depend on functional brain networks being able to communicate efficiently while also maintaining some degree of modularity. Evidence suggests that aging can disrupt this balance between integration and modularity. In this study, we examined how cognitive training affects the integration and modularity of functional networks in older and younger adults. Twenty three younger and 23 older adults participated in 10 days of verbal WM training, leading to performance gains in both age groups. Older adults exhibited lower modularity overall and a greater decrement when switching from rest to task, compared to younger adults. Interestingly, younger but not older adults showed increased task-related modularity with training. Furthermore, whereas training increased efficiency within, and decreased participation of, the default-mode network for younger adults, it enhanced efficiency within a task-specific salience/sensorimotor network for older adults. Finally, training increased segregation of the default-mode from frontoparietal/salience and visual networks in younger adults, while it diffusely increased between-network connectivity in older adults. Thus, while younger adults increase network segregation with training, suggesting more automated processing, older adults persist in, and potentially amplify, a more integrated and costly global workspace, suggesting different age-related trajectories in functional network reorganization with WM training.
Identifiants
pubmed: 33534925
doi: 10.1002/hbm.25337
pmc: PMC7978135
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1888-1909Subventions
Organisme : NIA NIH HHS
ID : T32 AG000247
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002241
Pays : United States
Organisme : NIH HHS
ID : S10 OD012240
Pays : United States
Organisme : NIH Office of the Director
ID : 1S10OD012240-01A1
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG045460
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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