Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders.
Alzheimer Disease
/ metabolism
Animals
Apoptosis
Autism Spectrum Disorder
/ metabolism
Behavior, Animal
Brain Injuries
Cognition Disorders
/ metabolism
Disease Models, Animal
Exosomes
/ metabolism
Extracellular Vesicles
/ metabolism
Humans
Inflammation
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Neurodegenerative Diseases
/ metabolism
Neurogenesis
Neurons
/ metabolism
Neuroprotection
Parkinson Disease
/ metabolism
Schizophrenia
/ metabolism
exosomes
mesenchymal stem cells
neurocognitive disorders
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
31
12
2020
revised:
26
01
2021
accepted:
27
01
2021
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.
Identifiants
pubmed: 33535376
pii: ijms22031433
doi: 10.3390/ijms22031433
pmc: PMC7867043
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Crohn's and Colitis Organization
ID : The role of galectin 3 in acute colitis
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : IZSEZ0 185546
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : ON175069; ON175103
Organisme : Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu
ID : MP01/18
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