Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
25 03 2021
25 03 2021
Historique:
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
5
2
2021
Statut:
ppublish
Résumé
An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs. Two glycogen synthase kinase-3 inhibitors (GSK-3i's), SB-216763 and tideglusib (the latter already in phase II clinical trials) that activate AKT/mTOR signaling were tested. These GSK-3i's reactivated latent HIV-1 present in blood samples from aviremic individuals on antiretroviral therapy (ART) in the absence of T cell activation, release of inflammatory cytokines, cell toxicity, or impaired effector function of cytotoxic T lymphocytes or NK cells. However, when administered
Identifiants
pubmed: 33536176
pii: JVI.02393-20
doi: 10.1128/JVI.02393-20
pmc: PMC8103695
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112457
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127219
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147777
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131374
Pays : United States
Organisme : NIH HHS
ID : S10 OD025002
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117901
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI083139
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150449
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Microbiology.
Références
Viruses. 2020 Feb 08;12(2):
pubmed: 32046251
Retrovirology. 2013 Dec 18;10:158
pubmed: 24351015
Sci Signal. 2011 Feb 22;4(161):ra10
pubmed: 21343617
Nature. 2012 Jul 25;487(7408):439-40
pubmed: 22836995
PLoS One. 2010 Nov 10;5(11):e15425
pubmed: 21085672
EBioMedicine. 2016 Jun;8:217-229
pubmed: 27428432
Nat Med. 2014 Apr;20(4):425-9
pubmed: 24658076
Nat Rev Mol Cell Biol. 2001 Oct;2(10):769-76
pubmed: 11584304
Cell Rep. 2020 Jun 23;31(12):107810
pubmed: 32579936
Semin Immunol. 2016 Oct;28(5):514-524
pubmed: 27825556
Int J Alzheimers Dis. 2011;2011:280502
pubmed: 21760986
J Exp Med. 2012 Apr 9;209(4):641-51
pubmed: 22451717
AIDS. 2013 Jan 14;27(2):F7-F11
pubmed: 22739395
Front Immunol. 2015 Jan 22;6:1
pubmed: 25657648
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
J Exp Med. 2004 Nov 15;200(10):1299-314
pubmed: 15545355
Immunity. 2008 Dec 19;29(6):1009-21
pubmed: 19062316
J Immunol. 2016 Aug 15;197(4):1183-98
pubmed: 27430715
Cell. 2006 Sep 8;126(5):955-68
pubmed: 16959574
Mov Disord. 2014 Apr;29(4):470-8
pubmed: 24532007
Blood. 2008 Feb 15;111(4):2101-11
pubmed: 18042802
Int J Alzheimers Dis. 2011;2011:479249
pubmed: 21629747
Elife. 2018 May 01;7:
pubmed: 29714165
J Immunol. 2002 Jan 1;168(1):29-43
pubmed: 11751943
Science. 2014 Jul 11;345(6193):169-74
pubmed: 25013067
Pathog Immun. 2016 Spring;1(1):68-106
pubmed: 27430032
J Pharm Biomed Anal. 2018 Jan 30;148:100-107
pubmed: 28982059
Cell. 2013 Oct 24;155(3):519-29
pubmed: 24243012
J Biol Chem. 2006 Oct 27;281(43):32385-94
pubmed: 16905544
Science. 2016 Jan 1;351(6268):48-52
pubmed: 26678875
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Antimicrob Agents Chemother. 2002 Nov;46(11):3447-55
pubmed: 12384349
Biochim Biophys Acta. 2015 Jun;1851(6):857-66
pubmed: 25463477
Science. 2011 Jun 10;332(6035):1317-22
pubmed: 21659604
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a007096
pubmed: 22229121
Pediatr Neurol. 2020 Nov;112:84-93
pubmed: 32942085
Trends Microbiol. 2016 Feb;24(2):90-97
pubmed: 26690612
J Vis Exp. 2015 Dec 12;(106):e53464
pubmed: 26709455
FEBS Lett. 2017 Oct;591(20):3319-3332
pubmed: 28892135
J Biol Chem. 2014 Sep 5;289(36):25227-40
pubmed: 24990947
J Virol. 2020 Oct 14;94(21):
pubmed: 32817214
Nature. 2020 Feb;578(7793):160-165
pubmed: 31969707
Nat Med. 2018 Sep;24(9):1430-1440
pubmed: 30082858
Immunity. 2002 Jun;16(6):769-77
pubmed: 12121659
J Neurochem. 2001 Apr;77(1):94-102
pubmed: 11279265
EBioMedicine. 2016 Apr;6:31-41
pubmed: 27211546
Oncotarget. 2016 Apr 19;7(16):21064-75
pubmed: 27027448
JCI Insight. 2017 Aug 3;2(15):
pubmed: 28768913
Emerg Microbes Infect. 2018 Aug 8;7(1):138
pubmed: 30087333
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Cell Host Microbe. 2016 Dec 14;20(6):785-797
pubmed: 27978436
J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94
pubmed: 19812304
PLoS One. 2007 Feb 28;2(2):e257
pubmed: 17330143
J Clin Invest. 2016 Feb;126(2):455-63
pubmed: 26731469
Sci Signal. 2009 Aug 18;2(84):ra46
pubmed: 19690332
Semin Immunol. 2020 Sep 24;:101412
pubmed: 32981836
Am J Physiol Cell Physiol. 2010 Jun;298(6):C1560-71
pubmed: 20200205
AIDS Res Hum Retroviruses. 2015 Jul;31(7):696-706
pubmed: 25891017
Front Mol Neurosci. 2011 Oct 31;4:32
pubmed: 22065134
Annu Rev Immunol. 2013;31:259-83
pubmed: 23298210
J Exp Med. 2015 Aug 24;212(9):1345-60
pubmed: 26261266
AIDS Res Hum Retroviruses. 2016 Feb;32(2):163-8
pubmed: 26150024
Cell Rep. 2018 Feb 6;22(6):1509-1521
pubmed: 29425506
J Alzheimers Dis. 2015;45(1):75-88
pubmed: 25537011
Sci Rep. 2016 Aug 02;6:30749
pubmed: 27480951
J Virol. 2014 Jul;88(14):8077-90
pubmed: 24807714
J Clin Invest. 2015 May;125(5):1901-12
pubmed: 25822022
Nat Rev Immunol. 2015 Sep 15;15(9):574-84
pubmed: 26272293
Front Immunol. 2018 Jun 22;9:1452
pubmed: 29988382
Depress Res Treat. 2012;2012:752563
pubmed: 23320155
J Exp Med. 2006 Jul 10;203(7):1665-70
pubmed: 16818670
Genes Dev. 2008 Jun 1;22(11):1490-500
pubmed: 18519641
J Virol. 2020 Apr 16;94(9):
pubmed: 32051267
Cell Host Microbe. 2018 Jan 10;23(1):14-26
pubmed: 29324227