Virus Control in Vaccinated Rhesus Macaques Is Associated with Neutralizing and Capturing Antibodies against the SHIV Challenge Virus but Not with V1V2 Vaccine-Induced Anti-V2 Antibodies Alone.


Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 03 2021
Historique:
received: 01 09 2020
accepted: 04 01 2021
pubmed: 5 2 2021
medline: 6 8 2021
entrez: 4 2 2021
Statut: ppublish

Résumé

The role of vaccine-induced anti-V2 Abs was tested in three protection experiments in rhesus macaques. In an experiment using immunogens similar to those in the RV144 vaccine trial (Anti-envelope [Env]), nine rhesus macaques were coimmunized with gp160

Identifiants

pubmed: 33536254
pii: jimmunol.2001010
doi: 10.4049/jimmunol.2001010
pmc: PMC7946713
mid: NIHMS1661248
doi:

Substances chimiques

AIDS Vaccines 0
Antibodies, Neutralizing 0
Antibodies, Viral 0
Gene Products, env 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1266-1283

Subventions

Organisme : NIAID NIH HHS
ID : HHSN272201800007C
Pays : United States
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112546
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118581
Pays : United States

Informations de copyright

Copyright © 2021 by The American Association of Immunologists, Inc.

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Auteurs

Ann J Hessell (AJ)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

Liuzhe Li (L)

Department of Pathology, New York University School of Medicine, New York, NY 10016.

Delphine C Malherbe (DC)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

Philip Barnette (P)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

Shilpi Pandey (S)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

William Sutton (W)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

David Spencer (D)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

Xiao-Hong Wang (XH)

Veterans Affairs New York Harbor Healthcare System, New York, NY 10010.

Johannes S Gach (JS)

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697.

Ruth Hunegnaw (R)

Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Michael Tuen (M)

Department of Pathology, New York University School of Medicine, New York, NY 10016.

Xunqing Jiang (X)

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.

Christina C Luo (CC)

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.

Celia C LaBranche (CC)

Division of Surgical Sciences, Duke University, Durham, NC 27710; and.

Yongzhao Shao (Y)

Department of Population Health, New York University School of Medicine, New York, NY 10016.

David C Montefiori (DC)

Division of Surgical Sciences, Duke University, Durham, NC 27710; and.

Donald N Forthal (DN)

Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697.

Ralf Duerr (R)

Department of Pathology, New York University School of Medicine, New York, NY 10016.

Marjorie Robert-Guroff (M)

Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Nancy L Haigwood (NL)

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.

Miroslaw K Gorny (MK)

Department of Pathology, New York University School of Medicine, New York, NY 10016; mirek.gorny@nyulangone.org.

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