A gene-environment-induced epigenetic program initiates tumorigenesis.

Adenocarcinoma / genetics Animals Carcinoma, Pancreatic Ductal / genetics Cell Transformation, Neoplastic / genetics Chromatin / genetics Disease Models, Animal Epigenesis, Genetic Female Gene-Environment Interaction Genomics Humans Interleukin-33 / metabolism Male Mice Mice, Inbred C57BL Nuclear Proteins / genetics Pancreas / metabolism Transcription Factors / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2021
Historique:
received: 29 01 2020
accepted: 18 12 2020
pubmed: 5 2 2021
medline: 27 3 2021
entrez: 4 2 2021
Statut: ppublish

Résumé

Tissue damage increases the risk of cancer through poorly understood mechanisms

Identifiants

DOI: 10.1038/s41586-020-03147-x PMID: 33536616 PMC: PMC8482641
pubmed: 33536616
doi: 10.1038/s41586-020-03147-x
pii: 10.1038/s41586-020-03147-x
pmc: PMC8482641
mid: NIHMS1656410
doi:

Substances chimiques

Brd4 protein, mouse 0
Chromatin 0
Interleukin-33 0
Nuclear Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

642-648

Subventions

Organisme : NCI NIH HHS
ID : T32 CA160001
Pays : United States
Organisme : NIH HHS
ID : 5T32CA160001-08
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA246901
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA177072
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023108
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA230195
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA230195
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA237736
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209975
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA013106
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA245797
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204228
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

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Auteurs

Direna Alonso-Curbelo (D)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Yu-Jui Ho (YJ)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cassandra Burdziak (C)

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.

Jesper L V Maag (JLV)

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

John P Morris (JP)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Rohit Chandwani (R)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Surgery, Weill Cornell Medical College, New York, NY, USA.
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA.

Hsuan-An Chen (HA)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-8979-3670

Kaloyan M Tsanov (KM)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Francisco M Barriga (FM)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-0996-7707

Wei Luan (W)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nilgun Tasdemir (N)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Geulah Livshits (G)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Elham Azizi (E)

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Jaeyoung Chun (J)

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-4164-0691

John E Wilkinson (JE)

Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Linas Mazutis (L)

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Steven D Leach (SD)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dartmouth Norris Cotton Cancer Center, Hanover, NH, USA.
David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-2689-1871

Richard Koche (R)

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6820-5083

Dana Pe'er (D)

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Scott W Lowe (SW)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.
Howard Hughes Medical Institute, Chevy Chase, MD, USA. lowes@mskcc.org.
ORCID: 0000-0002-5284-9650

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Eucaryotes › Animaux › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › A gene-environment-induced epigenetic program...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-33 › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Système digestif › Pancréas › A gene-environment-induced epigenetic program...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A gene-environment-induced epigenetic program...