Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits.
Administration, Intranasal
/ methods
Animals
Brain
/ pathology
Chemotherapy-Related Cognitive Impairment
/ pathology
Cisplatin
/ adverse effects
Cognition
Cognitive Dysfunction
/ pathology
Disease Models, Animal
Hippocampus
/ pathology
Humans
Memory
Mesenchymal Stem Cell Transplantation
/ methods
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Neurons
/ pathology
chemobrain
mesenchymal stem cell
mitochondria
nasal delivery
nrf2
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
09
2020
accepted:
12
12
2020
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Up to seventy-five percent of patients treated for cancer suffer from cognitive deficits which can persist for months to decades, severely impairing quality of life. Although the number of cancer survivors is increasing tremendously, no efficacious interventions exist. Cisplatin, most commonly employed for solid tumors, leads to cognitive impairment including deficits in memory and executive functioning. We recently proposed deficient neuronal mitochondrial function as its underlying mechanism. We hypothesized nasal administration of mitochondria isolated from human mesenchymal stem cells to mice, can reverse cisplatin-induced cognitive deficits.
Identifiants
pubmed: 33537077
doi: 10.7150/thno.53474
pii: thnov11p3109
pmc: PMC7847685
doi:
Substances chimiques
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3109-3130Subventions
Organisme : NCI NIH HHS
ID : R01 CA208371
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227064
Pays : United States
Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Oxid Med Cell Longev. 2020 May 11;2020:3050971
pubmed: 32454936
Acta Neuropathol Commun. 2018 Oct 1;6(1):103
pubmed: 30270813
Stem Cell Reports. 2018 Nov 13;11(5):1120-1135
pubmed: 30344008
Pediatr Res. 2012 Apr;71(4 Pt 2):474-81
pubmed: 22430383
Circ Res. 2011 May 27;108(11):1340-7
pubmed: 21493893
J Neurol Sci. 2017 Apr 15;375:417-423
pubmed: 28320180
Circ Res. 2020 Apr 10;126(8):e58-e59
pubmed: 32271681
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11600-5
pubmed: 23798392
Cell Transplant. 2018 Mar;27(3):501-514
pubmed: 29756518
J Neurotrauma. 2018 Aug 1;35(15):1800-1818
pubmed: 29648982
Acta Neuropathol Commun. 2018 Dec 12;6(1):139
pubmed: 30541620
Brain. 2019 May 1;142(5):1215-1226
pubmed: 30887021
Stem Cell Reports. 2016 Oct 11;7(4):749-763
pubmed: 27641650
Theranostics. 2019 Aug 14;9(20):5956-5975
pubmed: 31534531
Theranostics. 2019 Apr 13;9(8):2395-2410
pubmed: 31149051
J Clin Diagn Res. 2017 Jul;11(7):TD08-TD09
pubmed: 28893007
Health Psychol Open. 2019 Mar 05;6(1):2055102919832234
pubmed: 30873289
J Neurotrauma. 2007 Jun;24(6):991-9
pubmed: 17600515
J Clin Invest. 2018 Dec 3;128(12):5191-5194
pubmed: 30371508
Mov Disord. 2017 Mar;32(3):346-363
pubmed: 28251677
Am J Med Sci. 2015 Aug;350(2):132-8
pubmed: 26083647
Acta Oncol. 2012 Feb;51(2):185-97
pubmed: 21851186
PLoS One. 2012;7(7):e39600
pubmed: 22911687
PLoS One. 2015 Mar 25;10(3):e0119955
pubmed: 25806530
Front Neurol. 2015 Jul 20;6:155
pubmed: 26257702
Front Neurosci. 2015 Apr 21;9:131
pubmed: 25954147
Biochim Biophys Acta. 2006 Feb;1762(2):223-31
pubmed: 16278076
Cancer Res. 2017 Feb 1;77(3):742-752
pubmed: 27879267
Biol Open. 2015 Apr 10;4(5):622-6
pubmed: 25862247
JAMA Otolaryngol Head Neck Surg. 2018 Jan 1;144(1):71-79
pubmed: 29167901
Cancer. 2018 Jun 1;124(11):2289-2298
pubmed: 29461625
J Pharmacol Exp Ther. 1997 Feb;280(2):638-49
pubmed: 9023274
Stem Cell Res Ther. 2015 Dec 01;6:234
pubmed: 26620426
Cell Death Differ. 2017 Jul;24(7):1224-1238
pubmed: 28524859
Stem Cell Res Ther. 2018 Apr 13;9(1):106
pubmed: 29653590
Acta Neuropathol Commun. 2020 Nov 12;8(1):193
pubmed: 33183353
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8408-13
pubmed: 21536885
Circ Res. 2020 Mar 13;126(6):784-786
pubmed: 32078444
Mitochondrion. 2017 May;34:91-100
pubmed: 28242362
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1283-8
pubmed: 16432190
Eur J Cell Biol. 2009 Jun;88(6):315-24
pubmed: 19324456
Front Mol Neurosci. 2019 Mar 05;12:37
pubmed: 30890918
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12526-34
pubmed: 23852728
Oncotarget. 2018 Oct 30;9(85):35581-35597
pubmed: 30473752
Annu Rev Biochem. 1997;66:863-917
pubmed: 9242927
J Cell Mol Med. 2014 Aug;18(8):1694-703
pubmed: 24912369
J Cancer Sci Ther. 2019;11(4):
pubmed: 32148661
PLoS One. 2016 Mar 28;11(3):e0151890
pubmed: 27018597
Mitochondrion. 2017 May;34:127-134
pubmed: 28342934
Eur Heart J. 2006 May;27(9):1114-22
pubmed: 16510464
Mol Aspects Med. 2009 Feb-Apr;30(1-2):42-59
pubmed: 18601945
Innov Clin Neurosci. 2018 Feb 1;15(1-2):36-44
pubmed: 29497579
Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1088-1097
pubmed: 30759363
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Stem Cells Dev. 2013 Nov 1;22(21):2825-35
pubmed: 23767885
J Physiol. 1988 Aug;402:579-93
pubmed: 3236250
J Natl Cancer Inst. 2017 Dec 1;109(12):
pubmed: 29617869
Exp Neurol. 2014 May;255:137-44
pubmed: 24594220
Brain Imaging Behav. 2018 Apr;12(2):369-382
pubmed: 28290076
Nature. 2016 Jul 27;535(7613):551-5
pubmed: 27466127
Chem Rev. 1999 Sep 8;99(9):2467-98
pubmed: 11749487
Stem Cells. 2016 Aug;34(8):2210-23
pubmed: 27059413
Cells. 2019 Jun 15;8(6):
pubmed: 31208073
Theranostics. 2019 May 26;9(12):3595-3607
pubmed: 31281500
Int J Mol Sci. 2019 May 17;20(10):
pubmed: 31108944
Clin Microbiol Rev. 2014 Oct;27(4):691-726
pubmed: 25278572
Gynecol Oncol. 2010 Nov;119(2):366-9
pubmed: 20630576
Sci Rep. 2018 Nov 27;8(1):17400
pubmed: 30479361
Brain Res. 2008 Sep 10;1229:210-7
pubmed: 18657520
Trends Biochem Sci. 2015 Dec;40(12):728-735
pubmed: 26520802
Cell Transplant. 2016;25(5):913-27
pubmed: 26555763
J Exp Med. 1937 Jan 31;65(2):303-15
pubmed: 19870602
Acta Neuropathol Commun. 2020 Mar 20;8(1):36
pubmed: 32197663
Blood. 2003 Apr 15;101(8):2999-3001
pubmed: 12480709
Circ Res. 2020 Apr 10;126(8):e56-e57
pubmed: 32271682
Iran J Pharm Res. 2016 Winter;15(Suppl):185-195
pubmed: 28228816
Front Immunol. 2019 Jul 31;10:1645
pubmed: 31417542
Bioorg Chem. 2019 Jul;88:102925
pubmed: 31003078
Theranostics. 2019 Mar 17;9(7):2017-2035
pubmed: 31037154
Brain Connect. 2018 Sep;8(7):398-406
pubmed: 29999422
Sci Rep. 2019 Mar 26;9(1):5184
pubmed: 30914727