Organ-organ communication: The liver's perspective.
Angiotensinogen
/ genetics
Animals
Bone and Bones
/ metabolism
Brain
/ metabolism
Cytokines
/ genetics
Eye
/ metabolism
Fetuins
/ genetics
Fibroblast Growth Factors
/ genetics
Gene Expression Regulation
Humans
Intercellular Signaling Peptides and Proteins
/ genetics
Kidney
/ metabolism
Liver
/ metabolism
Lung
/ metabolism
Muscle, Skeletal
/ metabolism
Myocardium
/ metabolism
Proteoglycans
/ genetics
Signal Transduction
Cytokine
Disease mechanism.
Hepatokine
Liver
Organ communication
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
11
2020
accepted:
28
12
2020
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Communication between organs participates in most physiological and pathological events. Owing to the importance of precise coordination among the liver and virtually all organs in the body for the maintenance of homeostasis, many hepatic disorders originate from impaired organ-organ communication, resulting in concomitant pathological phenotypes of distant organs. Hepatokines are proteins that are predominantly secreted from the liver, and many hepatokines and several signaling proteins have been linked to diseases of other organs, such as the heart, muscle, bone, and eyes. Although liver-centered interorgan communication has been proposed in both basic and clinical studies, to date, the regulatory mechanisms of hepatokine production, secretion, and reciprocation with signaling factors from other organs are obscure. Whether other hormones and cytokines are involved in such communication also warrants investigation. Herein, we summarize the current knowledge of organ-organ communication phenotypes in a variety of diseases and the possible involvement of hepatokines and/or other important signaling factors. This provides novel insight into the underlying roles and mechanisms of liver-originated signal transduction and, more importantly, the understanding of disease in an integrative view.
Identifiants
pubmed: 33537089
doi: 10.7150/thno.55795
pii: thnov11p3317
pmc: PMC7847667
doi:
Substances chimiques
Cytokines
0
Enho protein, human
0
FGF21 protein, human
0
Fetuins
0
Intercellular Signaling Peptides and Proteins
0
Proteoglycans
0
TSKU protein, human
0
Angiotensinogen
11002-13-4
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3317-3330Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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