Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells.

NOTCH1 apoptosis cell proliferation malignant pleural mesothelioma metformin

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2020
Historique:
received: 12 02 2020
accepted: 15 12 2020
entrez: 4 2 2021
pubmed: 5 2 2021
medline: 5 2 2021
Statut: epublish

Résumé

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients die in a few months/years from diagnosis. Notch signaling is a well-conserved cell communication system, which regulates many biological processes. In humans, the dysregulation of Notch pathway potentially contributes to cancer onset/progression, including MPM. Metformin is the first-line drug used to treat type 2 diabetes mellitus. Metformin is proven to be an effective antitumor drug in preclinical models of different types of cancer. To date, clinical efficacy is being studied in many clinical trials. In this study, the anti-proliferative effect of metformin on MPM cells and the putative involvement of Notch1 as a mediator of metformin activities, were investigated. MPM cells showed high levels of Notch1 activation compared to normal pleural mesothelial cells. Furthermore, metformin treatment hampered MPM cell proliferation and enhanced the apoptotic process, accompanied by decreased Notch1 activation.

Identifiants

pubmed: 33537296
doi: 10.3389/fcell.2020.534499
pmc: PMC7849608
doi:

Types de publication

Journal Article

Langues

eng

Pagination

534499

Informations de copyright

Copyright © 2021 Rossini, Martini, Torreggiani, Fortini, Aquila, Vieceli Dalla Sega, Patergnani, Pinton, Maniscalco, Cavallesco, Rizzo and Tognon.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Marika Rossini (M)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Fernanda Martini (F)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

Elena Torreggiani (E)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Francesca Fortini (F)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Giorgio Aquila (G)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Francesco Vieceli Dalla Sega (FVD)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Simone Patergnani (S)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

Paolo Pinton (P)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

Pio Maniscalco (P)

Surgery Unit, Sant'Anna University Hospital, Ferrara, Italy.

Giorgio Cavallesco (G)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Paola Rizzo (P)

Laboratory for Technology of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.

Mauro Tognon (M)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Classifications MeSH