Design, synthesis, molecular docking, and some metabolic enzyme inhibition properties of novel quinazolinone derivatives.
Acetylcholinesterase
/ metabolism
Carbonic Anhydrases
/ metabolism
Dose-Response Relationship, Drug
Drug Design
Enzyme Inhibitors
/ chemical synthesis
Humans
Molecular Docking Simulation
Molecular Structure
Quinazolinones
/ chemical synthesis
Structure-Activity Relationship
alpha-Glucosidases
/ metabolism
3-aminoquinazolin-4(3H)-one
Schiff bases
enzyme inhibition
metabolic enzymes
molecular docking
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
03
01
2021
received:
02
12
2020
accepted:
07
01
2021
pubmed:
5
2
2021
medline:
4
11
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
3-Amino-2-ethylquinazolin-4(3H)-one (3) was synthesized in two steps from the reaction of amide (2), which was obtained from the treatment of methyl anthranilate (1) with propionyl chloride, with hydrazine. From the reaction of 3-amino-2-ethylquinazolin-4(3H)-one (3) with various aromatic aldehydes, novel benzylidenaminoquinazolin-4(3H)-one (3a-n) derivatives were synthesized. The structures of the novel molecules were characterized using infrared spectroscopy, nuclear magnetic resonance spectroscopy (
Identifiants
pubmed: 33537994
doi: 10.1002/ardp.202000455
doi:
Substances chimiques
Enzyme Inhibitors
0
Quinazolinones
0
Acetylcholinesterase
EC 3.1.1.7
alpha-Glucosidases
EC 3.2.1.20
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000455Informations de copyright
© 2021 Deutsche Pharmazeutische Gesellschaft.
Références
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