Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success.

Animals Drosophila Proteins / genetics Drosophila melanogaster / enzymology Reproduction / physiology Sterol Esterase / genetics Sterols / metabolism
D. melanogaster Drosophila adipocyte biochemistry chemical biology developmental biology fecundity hormone-sensitive lipase lipid metabolism mouse sterol

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
04 02 2021
Historique:
received: 28 09 2020
accepted: 03 02 2021
pubmed: 5 2 2021
medline: 29 1 2022
entrez: 4 2 2021
Statut: epublish

Résumé

Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissues or to progress ontogenetic transitions. In this study, we show that Hormone-sensitive lipase (Hsl) specifically controls SE mobilization to initiate intergenerational sterol transfer in

Identifiants

DOI: 10.7554/eLife.63252 PMID: 33538247 PMC: PMC7880688
pubmed: 33538247
doi: 10.7554/eLife.63252
pii: 63252
pmc: PMC7880688
doi:
pii:

Substances chimiques

Drosophila Proteins 0
Sterols 0
Sterol Esterase EC 3.1.1.13

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P40 OD018537
Pays : United States
Organisme : Austrian Science Fund FWF
ID : P 28882
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : M 2706
Pays : Austria

Informations de copyright

© 2021, Heier et al.

Déclaration de conflit d'intérêts

CH, OK, HH, WM, IP, LS, GS, HX, SG, AS, RK No competing interests declared

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Auteurs

Christoph Heier (C)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
BioTechMed-Graz, Graz, Austria.
ORCID: 0000-0001-6858-408X

Oskar Knittelfelder (O)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
ORCID: 0000-0002-1565-7238

Harald F Hofbauer (HF)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
BioTechMed-Graz, Graz, Austria.
ORCID: 0000-0003-2617-5901

Wolfgang Mende (W)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Ingrid Pörnbacher (I)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Laura Schiller (L)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Gabriele Schoiswohl (G)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Field of Excellence BioHealth - University of Graz, Graz, Austria.

Hao Xie (H)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Sebastian Grönke (S)

Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
ORCID: 0000-0002-1539-5346

Andrej Shevchenko (A)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
ORCID: 0000-0002-5079-1109

Ronald P Kühnlein (RP)

Institute of Molecular Biosciences, University of Graz, Graz, Austria.
BioTechMed-Graz, Graz, Austria.
Field of Excellence BioHealth - University of Graz, Graz, Austria.
Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hormone-sensitive lipase couples...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Hormone-sensitive lipase couples...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Hormone-sensitive lipase couples...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Hormone-sensitive lipase couples...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Sterol Esterase › Hormone-sensitive lipase couples...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Hormone-sensitive lipase couples...