Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors.
Protein misfolding
calcium homeostasis
memantine
membrane destabilization
neurodegenerative diseases
senile plaques
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
17 02 2021
17 02 2021
Historique:
pubmed:
5
2
2021
medline:
22
6
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Alzheimer's disease, which is the most common form of dementia, is characterized by the aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis caused by excessive activation of glutamatergic receptors (excitotoxicity). Here, we studied the effects on calcium homeostasis caused by the formation of Aβ oligomeric assemblies. We found that Aβ oligomers cause a rapid influx of calcium ions (Ca
Identifiants
pubmed: 33538575
doi: 10.1021/acschemneuro.0c00811
pmc: PMC7898266
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Receptors, N-Methyl-D-Aspartate
0
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
77521-29-0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
766-781Références
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Mol Pharmacol. 2011 Jan;79(1):141-7
pubmed: 20923851
Front Cell Neurosci. 2019 Jul 30;13:339
pubmed: 31417361
Neuron. 1994 Sep;13(3):645-55
pubmed: 7917295
J Biol Chem. 2012 Nov 9;287(46):39115-24
pubmed: 22995914
Commun Biol. 2020 Aug 13;3(1):435
pubmed: 32792544
J Alzheimers Dis. 2017;57(4):1041-1048
pubmed: 27662322
Cell Calcium. 2011 Mar;49(3):184-90
pubmed: 21349580
J Biol Chem. 2010 Mar 5;285(10):7619-32
pubmed: 20032460
Eur J Pharmacol. 2014 Sep 15;739:83-95
pubmed: 24316360
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27
pubmed: 23776240
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53
pubmed: 9600986
Chin J Integr Med. 2016 Jan 15;:
pubmed: 26779710
Annu Rev Biochem. 2017 Jun 20;86:27-68
pubmed: 28498720
J Biol Chem. 2000 May 12;275(19):14077-83
pubmed: 10799482
FEBS Lett. 1993 Feb 22;318(1):71-6
pubmed: 8436229
Cell Calcium. 2012 Jul;52(1):9-15
pubmed: 22430014
J Biol Chem. 2008 Oct 31;283(44):29950-60
pubmed: 18676369
Mol Neurodegener. 2017 Jul 6;12(1):53
pubmed: 28683776
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Neurol Sci. 2016 Jul;37(7):1039-47
pubmed: 26971324
J Mol Biol. 2004 May 14;338(5):943-57
pubmed: 15111058
Biochem Biophys Res Commun. 2002 May 31;294(1):42-5
pubmed: 12054737
Mol Neurodegener. 2017 Mar 21;12(1):27
pubmed: 28327181
J Cell Mol Med. 2011 Oct;15(10):2106-16
pubmed: 21155974
Nat Neurosci. 2012 Jan 29;15(3):349-57
pubmed: 22286176
Nat Neurosci. 2012 Sep;15(9):1227-35
pubmed: 22820466
Cell Calcium. 2019 Jun;80:112-116
pubmed: 31009822
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
J Biochem. 1997 Sep;122(3):498-505
pubmed: 9348075
J Physiol. 1998 Dec 1;513 ( Pt 2):317-30
pubmed: 9806985
J Neurochem. 1997 Jan;68(1):265-71
pubmed: 8978734
J Neurosci Res. 2017 Dec;95(12):2430-2447
pubmed: 28467650
Curr Alzheimer Res. 2013 Feb;10(2):143-53
pubmed: 22950913
J Biomed Sci. 2017 Jul 19;24(1):47
pubmed: 28720101
J Neurosci. 2009 Apr 1;29(13):4004-15
pubmed: 19339596
J Neurochem. 2010 Dec;115(6):1520-9
pubmed: 20950339
Neuroscience. 2004;128(2):347-57
pubmed: 15350646
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15978-83
pubmed: 21930925
Neurobiol Dis. 2003 Aug;13(3):177-90
pubmed: 12901832
ACS Chem Neurosci. 2019 Aug 21;10(8):3464-3478
pubmed: 31313906
Nat Neurosci. 2005 Aug;8(8):1051-8
pubmed: 16025111
J Cell Sci. 2012 May 15;125(Pt 10):2416-27
pubmed: 22344258
Nat Chem Biol. 2010 Feb;6(2):140-7
pubmed: 20081829
Front Neurol. 2018 Sep 26;9:797
pubmed: 30319529
Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247
pubmed: 28552522
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1540-5
pubmed: 17242368
Int J Mol Sci. 2020 Jun 25;21(12):
pubmed: 32630615
J Biol Chem. 2007 Apr 13;282(15):11590-601
pubmed: 17308309
Neurobiol Aging. 2014 Mar;35(3):472-81
pubmed: 24112789
Sci Rep. 2016 Sep 13;6:32721
pubmed: 27619987
J Biol Chem. 2005 Apr 29;280(17):17294-300
pubmed: 15722360
J Neurosci. 2006 Mar 22;26(12):3345-56
pubmed: 16554485
J Biol Chem. 2004 Nov 5;279(45):46363-6
pubmed: 15385542
Nat Commun. 2019 Jan 15;10(1):225
pubmed: 30644384
Int J Mol Sci. 2020 Oct 01;21(19):
pubmed: 33019683
Neurobiol Aging. 2011 Dec;32(12):2219-28
pubmed: 20133015
Biochim Biophys Acta. 1995 Oct 4;1239(1):58-66
pubmed: 7548145
J Alzheimers Dis. 2017;60(3):923-938
pubmed: 28922156
ACS Chem Neurosci. 2018 Dec 19;9(12):2959-2971
pubmed: 29986583
J Neurosci. 2016 Nov 9;36(45):11532-11543
pubmed: 27911757
J Neurosci. 2015 Nov 11;35(45):15157-69
pubmed: 26558786
Neurobiol Aging. 2013 Sep;34(9):2100-9
pubmed: 23601807
J Neurochem. 2001 Nov;79(3):595-605
pubmed: 11701763
Cell Calcium. 2010 Mar;47(3):264-72
pubmed: 20061018
Sci Rep. 2020 Sep 17;10(1):15280
pubmed: 32943652
Cell Calcium. 2016 Nov;60(5):289-298
pubmed: 27451385
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1745-1760
pubmed: 30059692