Association between small for gestational age and risk of autism spectrum disorders: a meta-analysis.
Autism spectrum disorder
Meta-analysis
Small for gestational age
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
03
12
2020
accepted:
16
01
2021
pubmed:
5
2
2021
medline:
5
2
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) remains unknown. This meta-analysis aimed to investigate the relationship between SGA and the risk of ASD. We searched PubMed, Web of Science, and Scopus databases from inception to November 2020. The heterogeneity across studies was explored using the I2 statistic. The possibility of publication bias was assessed using Begg test. The results were reported using the odds ratio (OR) and 95% confidence interval (CI) using a random-effects model. The literature search yielded 824 articles with 8,752,138 participants. We assessed the association between SGA and the risk of ASD in cohort and case-control studies. Based on the random-effects model, compared with SGA, the estimated OR of the risk of ASD was 1.17 (95% CI, 1.09-1.24). Therefore, there was a significant association between SGA and the risk of ASD. Based on OR reports in epidemiological studies, we showed that SGA is a risk factor for and can increase the risk of ASD. The association between SGA and ASD risk has further relevance to the current public health emphasis on appropriate prepregnancy weight and pregnancy weight gain.
Sections du résumé
BACKGROUND
BACKGROUND
The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) remains unknown.
PURPOSE
OBJECTIVE
This meta-analysis aimed to investigate the relationship between SGA and the risk of ASD.
METHODS
METHODS
We searched PubMed, Web of Science, and Scopus databases from inception to November 2020. The heterogeneity across studies was explored using the I2 statistic. The possibility of publication bias was assessed using Begg test. The results were reported using the odds ratio (OR) and 95% confidence interval (CI) using a random-effects model.
RESULTS
RESULTS
The literature search yielded 824 articles with 8,752,138 participants. We assessed the association between SGA and the risk of ASD in cohort and case-control studies. Based on the random-effects model, compared with SGA, the estimated OR of the risk of ASD was 1.17 (95% CI, 1.09-1.24). Therefore, there was a significant association between SGA and the risk of ASD.
CONCLUSION
CONCLUSIONS
Based on OR reports in epidemiological studies, we showed that SGA is a risk factor for and can increase the risk of ASD. The association between SGA and ASD risk has further relevance to the current public health emphasis on appropriate prepregnancy weight and pregnancy weight gain.
Identifiants
pubmed: 33539699
pii: cep.2020.01956
doi: 10.3345/cep.2020.01956
pmc: PMC8498018
doi:
Types de publication
Journal Article
Langues
eng
Pagination
538-542Subventions
Organisme : Hamadan University of Medical Sciences
ID : 9910167203
Références
J Pediatr. 2020 May;220:175-183.e8
pubmed: 32093932
J Pediatr. 2014 Jan;164(1):20-5
pubmed: 24161222
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Ann Epidemiol. 2014 Apr;24(4):260-6
pubmed: 24529515
Acta Psychiatr Scand. 2006 Oct;114(4):257-64
pubmed: 16968363
Autism. 2011 Mar;15(2):163-83
pubmed: 20923887
Pediatr Res. 2020 May;87(6):1045-1051
pubmed: 31791046
Obstet Gynecol. 2002 Aug;100(2):297-304
pubmed: 12151153
Mol Autism. 2017 Mar 17;8:13
pubmed: 28331572
Epidemiol Rev. 2002;24(2):137-53
pubmed: 12762089
Clin Exp Pediatr. 2020 Jan;63(1):8-13
pubmed: 31999913
Am J Epidemiol. 2005 May 15;161(10):916-25; discussion 926-8
pubmed: 15870155
Korean J Pediatr. 2019 Apr;62(4):126-130
pubmed: 30590001
Clin Exp Pediatr. 2020 Sep;63(9):368-372
pubmed: 32252143
Arch Gen Psychiatry. 2010 Aug;67(8):841-9
pubmed: 20679592
Arthritis Rheumatol. 2015 Dec;67(12):3201-8
pubmed: 26315754
Rev Paul Pediatr. 2019 Jul 18;37(4):398-405
pubmed: 31340243
Epidemiology. 2002 Jul;13(4):417-23
pubmed: 12094096
J Pediatr. 2012 Nov;161(5):830-6
pubmed: 22677565
J Autism Dev Disord. 2011 Jul;41(7):891-902
pubmed: 20922473
Autism Res. 2017 Feb;10(2):224-232
pubmed: 27220677
Pediatrics. 2009 Nov;124(5):e817-25
pubmed: 19841112
JAMA. 2017 Apr 18;317(15):1553-1562
pubmed: 28418479
Am J Obstet Gynecol. 2012 Apr;206(4):314.e1-9
pubmed: 22464070
Pediatrics. 2011 Aug;128(2):344-55
pubmed: 21746727
Matern Child Health J. 2015 Aug;19(8):1783-90
pubmed: 25776271
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120