Validation of a Novel Compact System for the Measurement of Lung Volumes.
novel measurement
physiology
plethysmograph
pulmonary function test
total lung capacity
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
02
10
2020
revised:
04
01
2021
accepted:
09
01
2021
pubmed:
5
2
2021
medline:
21
10
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Current techniques for measuring absolute lung volumes rely on bulky and expensive equipment and are complicated to use for the operator and the patient. A novel method for measurement of absolute lung volumes, the MiniBox method, is presented. Across a population of patients and healthy participants, do values for total lung capacity (TLC) determined by the novel compact device (MiniBox, PulmOne Advanced Medical Devices, Ltd.) compare favorably with measurements determined by traditional whole body plethysmography? A total of 266 participants (130 men) and respiratory patients were recruited from five global centers (three in Europe and two in the United States). The study population comprised individuals with obstructive (n = 197) and restrictive (n = 33) disorders as well as healthy participants (n = 36). TLC measured by conventional plethysmography (TLC TLC values ranged between 2.7 and 10.9 L. The normalized root mean square difference (NSD) between TLC TLC as measured by the novel MiniBox system is not significantly different from TLC measured by conventional whole body plethysmography, thus validating the MiniBox method as a reliable method to measure absolute lung volumes.
Sections du résumé
BACKGROUND
Current techniques for measuring absolute lung volumes rely on bulky and expensive equipment and are complicated to use for the operator and the patient. A novel method for measurement of absolute lung volumes, the MiniBox method, is presented.
RESEARCH QUESTION
Across a population of patients and healthy participants, do values for total lung capacity (TLC) determined by the novel compact device (MiniBox, PulmOne Advanced Medical Devices, Ltd.) compare favorably with measurements determined by traditional whole body plethysmography?
STUDY DESIGN AND METHODS
A total of 266 participants (130 men) and respiratory patients were recruited from five global centers (three in Europe and two in the United States). The study population comprised individuals with obstructive (n = 197) and restrictive (n = 33) disorders as well as healthy participants (n = 36). TLC measured by conventional plethysmography (TLC
RESULTS
TLC values ranged between 2.7 and 10.9 L. The normalized root mean square difference (NSD) between TLC
INTERPRETATION
TLC as measured by the novel MiniBox system is not significantly different from TLC measured by conventional whole body plethysmography, thus validating the MiniBox method as a reliable method to measure absolute lung volumes.
Identifiants
pubmed: 33539839
pii: S0012-3692(21)00208-7
doi: 10.1016/j.chest.2021.01.052
pmc: PMC8411450
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2356-2365Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES030990
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148152
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007118
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
Références
J Appl Physiol (1985). 1988 Feb;64(2):823-31
pubmed: 3372439
Clin Physiol. 1985 Apr;5(2):179-87
pubmed: 3995879
Chest. 2012 Aug;142(2):506-510
pubmed: 22871760
Am J Respir Crit Care Med. 2005 Mar 15;171(6):591-7
pubmed: 15591470
Clin Physiol. 1988 Apr;8(2):113-9
pubmed: 3359746
Am Rev Respir Dis. 1982 Dec;126(6):1040-4
pubmed: 7181224
Thorax. 1999 Apr;54(4):329-33
pubmed: 10092694
Respir Med. 1993 Feb;87(2):115-20
pubmed: 8497680
Respiration. 2016;91(4):273-80
pubmed: 26982496
Thorax. 1983 Jun;38(6):468-71
pubmed: 6879500
Eur Respir J. 2005 Sep;26(3):511-22
pubmed: 16135736
Int J Chron Obstruct Pulmon Dis. 2012;7:119-26
pubmed: 22399851
Eur Respir J. 2005 Nov;26(5):948-68
pubmed: 16264058
Chest. 2010 May;137(5):1108-15
pubmed: 20022972
J Thorac Imaging. 2017 Mar;32(2):101-106
pubmed: 27870822
Am Rev Respir Dis. 1992 Sep;146(3):570-6
pubmed: 1519830
J Appl Physiol (1985). 1997 Mar;82(3):1018-23
pubmed: 9074996
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882